dc.contributor.author | Aja, Patrick Maduabuchi | |
dc.contributor.author | Chukwu, Chinecherem Adanna | |
dc.contributor.author | Ugwu, Okechukwu Paul-Chima | |
dc.contributor.author | Ale, Boniface Anthony | |
dc.contributor.author | Agu, Peter Chinedu | |
dc.contributor.author | Deusdedi, Tusubira | |
dc.contributor.author | Chukwu, Darlington C. | |
dc.contributor.author | l Ani, Onyedika Gabrie | |
dc.contributor.author | Ekpono, Ezebuilo Ugbala | |
dc.contributor.author | Ogwoni, Hilary Akobi | |
dc.contributor.author | Awoke, Joshua Nonso | |
dc.contributor.author | Ogbu, Patience N. | |
dc.contributor.author | Aja, Lucy | |
dc.contributor.author | Ukachi, Oliver Ugochukwu | |
dc.contributor.author | Orji, Obasi Uche | |
dc.contributor.author | Nweke, Chinoso Peter | |
dc.contributor.author | Egwu, Chinedu | |
dc.contributor.author | Ekpono, Ejike Ugbala | |
dc.contributor.author | Ewa, Gift Onyinyechi | |
dc.contributor.author | et al | |
dc.date.accessioned | 2024-04-30T08:00:18Z | |
dc.date.available | 2024-04-30T08:00:18Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Aja, P. M., Chukwu, C. A., Ugwu, O. P. C., Ale, B. A., Agu, P. C., Deusdedi, T., ... & Daniel Eze, E. (2024). Cucumeropsis mannii seed oil protects against bisphenol A-induced hepatotoxicity by mitigating inflammation and oxidative stress in rats. RPS Pharmacy and Pharmacology Reports, 3(1), rqad033. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/3617 | |
dc.description.abstract | Objectives: This study looked at how Cucumeropsis mannii seed oil (CMSO) affected male Wistar albino rats’ liver damage caused by bisphenol A (BPA).
Methods: The standard HPLC method was used to assess the CMSO’s phenolic content. Then, six (n = 8) groups of 48 male Wistar rats (150 20 g) each received either CMSO or olive oil before being exposed to BPA for 42 days. Groups: A (1 ml of olive oil, regardless of weight), B (BPA 100 mg/kg body weight (BW)), C (CMSO 7.5 mg/kg BW), D (CMSO 7.5 mg/kg BW + BPA 100 mg/kg BW), E (CMSO 5.0 mg/kg BW + BPA 100 mg/kg BW), and F (CMSO 2.5 mg/kg BW + BPA 100 mg/kg BW).
Key findings: A surprising abundance of flavonoids, totalling 17.8006 10.95 g/100 g, were found in the HPLC data. Malondialdehyde, liver enzymes, reactive oxygen species, total bilirubin, and direct bilirubin levels were all significantly elevated by BPA (P = 0.05). Additionally, nuclear Factor-B, interleukin-6, interleukin-1, tumour necrosis factor, and histological alterations were all considerably (P = 0.05) caused by BPA. The altered biochemical markers and histology were, however, noticeably recovered by CMSO to a level that was comparable to the control. Conclusions: Due to the abundance of flavonoid components in the oil, CMSO protects the liver from BPA-induced hepatotoxicity by lowering oxidative stress and inflammatory reactions | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | RPS Pharmacy and Pharmacology Reports | en_US |
dc.subject | Bisphenol A | en_US |
dc.subject | Hepatotoxicity | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Anti-inflammation | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Cucumeropsis mannii | en_US |
dc.subject | Flavonoids profile | en_US |
dc.title | Cucumeropsis mannii seed oil protects against bisphenol A-induced hepatotoxicity by mitigating inflammation and oxidative stress in rats | en_US |
dc.type | Article | en_US |