dc.contributor.author | Nanzigu, Sarah | |
dc.contributor.author | Waako, Paul | |
dc.contributor.author | Petzold, Max | |
dc.contributor.author | Kiwanuka, Gertrude | |
dc.contributor.author | Dungu, Henry | |
dc.contributor.author | Makumbi, Fred | |
dc.contributor.author | Gustafsson, Lars L. | |
dc.contributor.author | Eriksen, Jaran | |
dc.date.accessioned | 2024-05-13T12:31:20Z | |
dc.date.available | 2024-05-13T12:31:20Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Nanzigu, S., Waako, P., Petzold, M., Kiwanuka, G., Dungu, H., Makumbi, F., ... & Eriksen, J. (2011). CD4-T-lymphocyte reference ranges in Uganda and its influencing factors. Laboratory Medicine, 42(2), 94-101. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/3647 | |
dc.description.abstract | Background: Given the importance of CD4-T-lymphocyte monitoring in HIV/ART management, we established CD4/CD8 reference ranges in Uganda and studied factors associated with CD4/CD8 in a normal population.
Methods: Blood samples for 206 HIV seronegative healthy volunteers from the Mbarara and Kampala districts in Uganda were analyzed using the PanLeucogating protocol.
Results: The reference ranges reported include data from 172 participants with no current or serious recent health problems. The 95% reference ranges for absolute CD4 (ACD4) count was 418-2105 cells/µL, 2561619 for absolute CD8 count, and 0.52-4.1 for CD4/CD8 cell ratio, which is wider than the reference ranges currently used in Uganda. Recent illnesses/medications and sociodemographic factors affected the CD4- T-lymphocyte count.
Conclusion: The CD4 reference ranges in Uganda were established using a cost-effective method, recommended and available in resource-limited settings. Effect of prevalent infections and socio-demographic differences on CD4-T-lymphocyte levels would need consideration in HIV/ART clinical management. | en_US |
dc.description.sponsorship | SIDASarec program | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Laboratory Medicine | en_US |
dc.subject | CD4-T lymphocytes | en_US |
dc.subject | HIV/AIDS | en_US |
dc.subject | Hematology | en_US |
dc.subject | Ugandans | en_US |
dc.subject | Socio-demographic factors | en_US |
dc.subject | Infectious disease | en_US |
dc.title | CD4-T-Lymphocyte Reference Ranges in Uganda and Its Influencing Factors | en_US |
dc.type | Article | en_US |