Department of Pharmacy: Recent submissions
Now showing items 1-20 of 192
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Protective effects of Sphaeranthus indicus floral extract against BPS induced testicular damage in rats occurs through downregulation of RIPK1/3-MLK-driven necroptosis and Fas-FasL-mediated apoptosis
(Advances in Traditional Medicine, 2024)Bisphenol S (BPS) is one of the monomers preferred in the manufacturing of polycarbonate plastics. Unfortunately, its estrogenic and genotoxic effects are similar to those of bisphenol A. The protective effects of Sphaeranthus ... -
Safety and Efficacy of Jenacid® Herbal Product Against Indomethacin-Induced Ulcers in Albino Wistar Rats
(Cureus, 2024)Background: Jenacid Herbal Product (JHP) used for treating peptic ulcer disease in Uganda, sold over the counter, is approved by the National Drug Authority as a Traditional Herbal Product number THP 482. There have been ... -
Evaluation of the effects of Artemisia Annua L. and Moringa Oleifera Lam. on CD4 count and viral load among PLWH on ART at Mbarara Regional Referral Hospital: a double-blind randomized controlled clinical trial
(AIDS Research and Therapy, 2024)Background: Initiation of ART among people living with HIV (PLWH) having a CD4 count ≤ 350cells/µl, produces poor immunological recovery, putting them at a high risk of opportunistic infections. To mitigate this, PLWH on ... -
Hepatitis Cvirus diversity and treatment outcomes in Benin: a prospective cohort study
(The Lancet Microbe, 2024)Background: 10 million people are chronically infected with the hepatitis C virus (HCV) in sub-Saharan Africa. The assessment of viral genotypes and treatment response in this region is necessary to achieve the WHO target ... -
Sub- and supratherapeutic efavirenz plasma concentrations with risk for HIV therapy failure are mainly genetically explained in Ugandan children: The prospective GENEFA cohort study
(British Journal of Clinical Pharmacology, 2024)Aims: Interindividual variations in efavirenz (EFV) plasma concentrations are extensive, but paediatric data on its consequences for viral control are scarce. The aim of this study was to explore the role of genetic variation ... -
Drug therapy problems related to cardiovascular agents and associated factors among heart failure patients: a prospective observational study of a tertiary inpatient setting in Uganda
(Journal of Clinical and Translational Research, 2024)Background: Heart failure (HF) is a clinical syndrome that is treated with multiple medications, putting patients at risk of drug therapy problems (DTPs). DTPs are a great concern in health care due to their significant ... -
Antimicrobial resistance and rational prescription practices: knowledge, perceptions and confidence of health profession interns in Uganda
(JAC-Antimicrobial Resistance, 2023)Background: Antimicrobial resistance (AMR) is significantly driven by misuse and overuse of antibiotics. Graduate health profession interns often prescribe antimicrobials under minimum supervision. Objectives: This study ... -
Prevalence, classifications and factors associated with sexual dysfunction among adult cancer patients on chemotherapy at the Uganda Cancer Institute, Mbarara
(BMC Cancer, 2024)Background: Sexual dysfunction is a social challenge that devastates many people, including cancer patients. However, among the numerous reported side effects of chemotherapy sexual dysfunction is the least studied and ... -
Appetite Suppressing Activity of Rumex Usambarensis Leaf and Stem Aqueous Extract in Wistar Albino Female Rats: an in vivo Experimental Study
(Journal of Experimental Pharmacology, 2024)Background: The burden of obesity and overweight associated morbidity and mortality is increasing in epidemic proportions worldwide. Suppression of appetite is one of the mechanisms that has been shown to reduce weight. ... -
Pharmacognostical evaluation and description of the leaf and root bark of Citropsis articulata Swingle & Kellerman
(Phytomedicine Plus, 2024)Background: Citropsis articulata Swingle & Kellerman (Family Rutaceae) is a renowned African traditional medicinal plant for the management of erectile dysfunction. The root bark is more commonly used than the leaves. ... -
Appetite Suppressing Activity of Rumex Usambarensis Leaf and Stem Aqueous Extract in Wistar Albino Female Rats: an in vivo Experimental Study
(Journal of Experimental Pharmacology, 2024)Background: The burden of obesity and overweight associated morbidity and mortality is increasing in epidemic proportions worldwide. Suppression of appetite is one of the mechanisms that has been shown to reduce weight. ... -
Preclinical immunomodulatory activity of COVIDEX® herbal product developed for supportive treatment of COVID-19 in Uganda
(African Journal of Pharmacy and Pharmacology, 2024)The outbreak of the COVID-19 pandemic due to the SARSCoV-2 virus caused international lockdown with devastating effects on global health. In Africa, most people resorted to the use of herbal products for the prevention and ... -
Impact of Artemisia annua and Moringa oleifera on Viral Load, T Cell Activation, and Exhaustion in Ugandan People Living with HIV/AIDS (PLWH)
(African Journal of Pharmacy and Pharmacology, 2024)Highly active antiretroviral therapy (HAART) effectively controls HIV replication in HIV-positive individuals, but chronic immune activation persists, leading to increased virus replication, T cell depletion, and exhaustion, ... -
Anticancer potential of delphinidin and its derivatives: therapeutic and mechanistic insights
(Medicinal Chemistry Research, 2024)Anthocyanins are water-soluble naturally occurring flavonoids present in fruits, flowers, leaves, and roots of fruit plants and vegetables. One of the important anthocyanidin components of red wine and berries is delphinidin ... -
Prevalence and risk factors of chemotherapy- induced oral mucositis among adult cancer patients at the cancer unit of Mbarara Regional Referral Hospital
(Asia‐Pacific Journal of Clinical Oncology, 2024)Background: Chemotherapy is a common treatment for cancer, but it is associated with adverse drug reactions like oral mucositis. This condition destroys basal cells in the oral mucosal layer, causing inflammation and ... -
Comparison of Antibacterial Activities of Fermented with those of Unfermented Annona muricata (L) Fruit Extracts
(International Journal for Microbiology and Applied sciences, 2015)Fermentation is known to enhance antibacterial activities of some plant products. The research aimed to compare the antibacterial activities of the fermented with those of unfermented fruits of Annona muricata, obtained ... -
The Impact on Public Health and Economy Using Lockdown as a Tool against COVID-19 Pandemic in Africa: A Perspective
(Journal of Epidemiology and Public Health Reviews, 2020)Background: Since the spread of Corona Virus Disease 19 (COVID-19) most African countries have embarked on a system of either total or partial lockdown and have used it as a tool for curbing the spread of COVID-19. This ... -
Impact of Global Health Scholarship Programs in the Faculty of Medicine at Mbarara University of Science and Technology
(International Medical Education, 2024)In recognition of the critical role of residency programs in narrowing health care inequalities, Global Health scholarships were introduced at Mbarara University of Science and Technology (MUST) in 2011. Since then, at ... -
Effectiveness of Jena DM® Herbal Formulation as Complementary Therapy to Conventional Oral Hypoglycemic Agents in Type-2 Diabetes Mellitus: A Quasi-Experimental Study
(Cureus, 2024)Background: There is vast preclinical evidence that indicates that extracts from several Artemisia plant species have significant antidiabetic benefits. However, clinical evidence is limited to this effect. Objective: We ... -
A Comparison Analysis on Remdesivir, Favipiravir, Hydroxychloroquine, Chloroquine and Azithromycin in the Treatment of Corona Virus Disease 2019 (Covid-19) - A Review
(World Journal of Pharmacy and Pharmaceutical Sciences, 2020)Background: This comparative study is to ascertain the efficacy and results proven drug used in the management of the novel corona virus disease 19 since most patients admitted are recovering while there is no clinically ...
