dc.contributor.author | Owaraganise, Asiphas | |
dc.contributor.author | Ssalongo, Wasswa GM | |
dc.contributor.author | Tibaijuka, Leevan | |
dc.contributor.author | Kayondo, Musa | |
dc.contributor.author | Twesigomwe, Godfrey | |
dc.contributor.author | Ngonzi, Joseph | |
dc.contributor.author | Lugobe, Henry M | |
dc.date.accessioned | 2022-01-13T13:34:14Z | |
dc.date.available | 2022-01-13T13:34:14Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Owaraganise, A., Ssalongo, W. G., Tibaijuka, L., Kayondo, M., Twesigomwe, G., Ngonzi, J., & Lugobe, H. M. (2021). Non-Proteinuric Preeclampsia: Prevalence, Factors Associated and End-Organ Dysfunction at Mbarara Regional Referral Hospital in Southwestern Uganda. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/1161 | |
dc.description.abstract | Background: Formerly, preeclampsia was only diagnosed if high blood pressure and proteinuria were present in a gravid woman at or past 20 gestation weeks. Although it is possible to have preeclampsia yet never have proteinuria, the literature on how common and factors associated with non-proteinuric preeclampsia as well as whether the frequency of end-organ dysfunction among women with nonproteinuric differs from those with proteinuric pre-eclampsia is scant.
Objectives: To determine the prevalence of, factors associated with non-proteinuric preeclampsia, and compare the frequency of end-organ dysfunction between women with non-proteinuric and proteinuric preeclampsia.
Methods: Between November 2019 and May 2020, women with pre-eclampsia were consecutively enrolled in a cross-sectional study at Mbarara Regional Referral Hospital. We interviewed all pregnant women ≥20 gestation weeks presenting with hypertension ≥140/90mmHg and recorded their sociodemographic, medical, and obstetric characteristics. We excluded women with chronic hypertension and pregnancy hypertension. We measured bedside proteinuria on clean-catch urine, complete blood count, and renal function and liver enzyme tests. Pre-eclampsia was defined as hypertension plus any feature of severity including <100,000 platelets/ul, creatinine >1.1g/dl, and liver transaminases ≥ twice upper normal limit with or without proteinuria. We computed the proportion of total participants with nonproteinuric
pre-eclampsia at ≤+2 urine dipstick cut-off, determined the factors associated with nonproteinuric preeclampsia using logistic regression; and used Chi-square test to compare the frequency of end-organ dysfunction between non-proteinuric preeclampsia and proteinuric groups.
Results: We enrolled 134 of the screened 136 participants. Their mean age was 26.9 (SD±7.1) years and 51.5% were primigravid. The prevalence of non-proteinuric preeclampsia was 24.6% (95% CI: 17.9-32.7). Primigravidity (aOR 2.70 95%CI:1.09-6.72, p=0.032) was the factor independently associated with nonproteinuric pre-eclampsia. There was a non-significant difference in the frequency of end-organ dysfunction in women with non-proteinuric and proteinuric pre-eclampsia, p=0.309.
Conclusion: Non-proteinuric preeclampsia is common, especially among primigravidae. End-organ dysfunction occurs similarly in women with non-proteinuric and proteinuric preeclampsia. Obstetrics care providers should emphasize laboratory testing, beyond proteinuria, among all women with hypertensive disorders of pregnancy to optimally diagnose and manage non-proteinuric preeclampsia.
Synopsis
Non-proteinuric preeclampsia is common and associated with primigravidity. Since women suffer similar end-organ dysfunction, proteinuria testing alone is insufficient to diagnose their pre-eclampsia syndrome. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Research Square | en_US |
dc.subject | Pregnancy | en_US |
dc.subject | Non-proteinuric | en_US |
dc.subject | Proteinuric | en_US |
dc.subject | Preeclampsia | en_US |
dc.subject | End-organ | en_US |
dc.subject | Dysfunction | en_US |
dc.subject | Mbarara | en_US |
dc.title | Non-Proteinuric Preeclampsia: Prevalence, Factors Associated and End-Organ Dysfunction at Mbarara Regional Referral Hospital in Southwestern Uganda | en_US |
dc.type | Article | en_US |