dc.contributor.author | Weiser, Sheri D | |
dc.contributor.author | Gupta, Reshma | |
dc.contributor.author | Tsai, Alexander C | |
dc.contributor.author | Frongillo, Edward A | |
dc.contributor.author | Grede, Nils | |
dc.contributor.author | Kumbakumba, Elias | |
dc.contributor.author | Kawuma, Annet | |
dc.contributor.author | Hunt, Peter W | |
dc.contributor.author | Martin, Jeffrey N | |
dc.contributor.author | Bangsberg, David R | |
dc.date.accessioned | 2022-05-05T11:41:20Z | |
dc.date.available | 2022-05-05T11:41:20Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Weiser, S. D., Gupta, R., Tsai, A. C., Frongillo, E. A., Grede, N., Kumbakumba, E., ... & Bangsberg, D. R. (2012). Changes in food insecurity, nutritional status, and physical health status after antiretroviral therapy initiation in rural Uganda. Journal of acquired immune deficiency syndromes (1999), 61(2), 179. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/1855 | |
dc.description.abstract | Objective
To investigate whether time on antiretroviral treatment (ART) is associated with improvements in food security and nutritional status, and the extent to which associations are mediated by improved physical health status (PHS).
Design
The Uganda AIDS Rural Treatment Outcomes study (UARTO), a prospective cohort of HIV-infected adults newly initiating ART in Mbarara, Uganda.
Methods
Participants initiating ART underwent quarterly structured interview and blood draws. The primary explanatory variable was time on ART, constructed as a set of binary variables for each three-month period. Outcomes were food insecurity, nutritional status and PHS.
We fit multiple regression models with cluster-correlated robust estimates of variance to account for within-person dependence of observations over time, and analyses were adjusted for clinical and socio-demographic characteristics.
Results
228 ART-naive participants were followed for up to 3 years, and 41% were severely food insecure at baseline. The mean food insecurity score progressively declined (test for linear trend P<0.0001), beginning with the second quarter (b=-1.6; 95% CI, -2.7 to -0.45) and ending with the final quarter (b=-6.4; 95% CI, -10.3 to -2.5). PHS and nutritional status improved in a linear fashion over study follow-up (P<0.001). Inclusion of PHS in the regression model attenuated the relationship between ART duration and food security | en_US |
dc.description.sponsorship | NIH K23 MH-079713 (PI: Weiser), MH-79713-03S1 (PI: Weiser), R01
MH-54907 (PI: Bangsberg), P30 AI27763(UCSF-Gladstone Institute Center for AIDS Research), and the Tim and
Jane Meyer Family Foundation. Additional funding for study analyses was provided by the World Food
Programme. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | J Acquir Immune Defic Syndr. 2012 October 1; 61(2): 179–186. doi:10.1097/QAI.0b013e318261f064. | en_US |
dc.subject | Food insecurity | en_US |
dc.subject | Nutritional status | en_US |
dc.subject | Physical health status | en_US |
dc.subject | Antiretroviral Therapy | en_US |
dc.subject | Rural Uganda | en_US |
dc.title | Changes in food insecurity, nutritional status, and physical health status after antiretroviral therapy initiation in rural Uganda | en_US |
dc.type | Article | en_US |