Faculty of Medicine: Recent submissions
Now showing items 1061-1080 of 1992
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Depression and suicidal ideation among HIV-infected adults receiving efavirenz versus nevirapine in Uganda: a prospective cohort study
(Annals of internal medicine, 2018)Background: There is conflicting evidence about potential adverse neuropsychiatric effects of efavirenz and limited data from sub-Saharan Africa, where efavirenz is used as first-line therapy and 70% of people living with ... -
CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in Uganda: Pooled Analysis of Two Prospective Studies
(AIDS research and human retroviruses, 2018)Single-nucleotide polymorphisms (SNPs) in CYP2B6 have been shown to predict variation in plasma efavirenz concentrations, but associations between these SNPs and efavirenz-mediated depression and viral suppression are less ... -
Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis
(Mediators of Inflammation, 2020-10-29)Background: Though peripheral blood is a crucial sample to study immunology, it is unclear whether the immune environment in the peripheral vasculature correlates with that at the end-organ site of infection. Using ... -
Brief report: No association found between traditional healers use and delayed antiretroviral initiation in rural Uganda
(AIDS and Behavior, 2013)Traditional healer and/or spiritual counselor (TH/SC) use has been associated with delays in HIV testing. We examined HIV-infected individuals in southwestern Uganda to test the hypothesis that TH/SC use was also associated ... -
Association Between Immunoglobulin E Levels and Kaposi Sarcoma in African Adults With Human Immunodeficiency Virus Infection
(The Journal of Infectious Diseases, 2021)It has been demonstrated that activated mast cells (MCs) are enriched in Kaposi sarcoma (KS) tumors and contribute to the inflammatory microenvironment. Mechanisms driving MC activation, however, are incompletely understood. ... -
Antiretroviral Therapy Adherence Interruptions are Associated with Systemic Inflammation among Ugandans who Achieved Viral Suppression
(Journal of acquired immune deficiency syndromes, 2019)Background: Residual systemic inflammation, which is associated with non-AIDS clinical outcomes, may persist despite viral suppression. We assessed the effect of antiretroviral (ART) adherence interruptions on systemic ... -
Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes
(Retrovirology, 2013)Background: The highly genetically diverse HIV-1 group M subtypes may differ in their biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a comprehensive inter-subtype comparison ... -
A pragmatic approach to managing antiretroviral therapy-experienced patients diagnosed with HIVassociated cryptococcal meningitis: impact of antiretroviral therapy adherence and duration
(AIDS, 2020)Cryptococcal meningitis accounts for 15% of all HIV related deaths [1]. The overall number of cryptococcal meningitis cases has remained relatively stable in many low-to-middle income countries (LMICs) despite increasing ... -
A Journey of Hope: giving research participants a voice to share their experiences and improve community engagement around advanced HIV disease in Uganda [version 2; peer review: 2 approved]
(AAS open research, 2020)Over the last decade excellent progress has been made globally in HIV management thanks to antiretroviral therapy (ART) rollout and international guidelines now recommending immediate initiation of ART in people living ... -
Evaluation of a point-of-care immunoassay test kit `StrongStep' for cryptococcal antigen detection
(PLoS One, 2018)Background: HIV-associated cryptococcal meningitis is the leading cause of adult meningitis in Sub- Saharan Africa, accounting for 15%±20% of AIDS-attributable mortality. The development of point-of-care assays has greatly ... -
Dissemination of Research Findings to Research Participants Living with HIV in Rural Uganda: Challenges and Rewards
(PLOS Medicine, 2013-03-05)Community participatory research emphasizes communication of study findings to research participants of vulnerable populations [1]. Most dissemination activities in sub-Saharan Africa have occurred after the completion (or ... -
Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes
(Journal of virology, 2020)Downregulation of BST-2/tetherin and CD4 by HIV-1 viral protein U (Vpu) promotes viral egress and allows infected cells to evade host immunity. Little is known however about the natural variability in these Vpu functions ... -
Qualité sanitaire du lait cru tout au long de la filière dans le district de Mbarara et la ville de Kampala en Ouganda
(Revue d’élevage et de médecine vétérinaire des pays tropicaux, 2005)La qualité sanitaire du lait cru est une problématique importante en Ouganda, tant pour des raisons socio-économiques que sanitaires. L’étude conduite sur la filière informelle du lait cru en Ouganda a mis en évidence deux ... -
Prospect into therapeutic potentials of Moringa oleifera phytocompounds against cancer upsurge: de novo synthesis of test compounds, molecular docking, and ADMET studies
(Bulletin of the National Research Centre, 2021)Background: Cancer chemotherapy is difficult because current medications for the treatment of cancer have been linked to a slew of side effects; as a result, researchers are tasked with developing greener cancer chemotherapies. ... -
Prevalence, Correlates and Treatment Needs of Dental Caries Among People on Antiretroviral Therapy in Uganda: A Cross Sectional Study
(Research square, 2022)Background: Oral diseases are estimated to affect half of people living with HIV in the global north, and are often marked by pain, discomfort, disfigurement and reduced quality of life. Both HIV-specific and antiretroviral ... -
Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer
(Molecular Cancer, 2022)Background: Detecting cancer at an early stage before clinical manifestation could be an effective strategy to decrease cancer mortality. Thus, identifying liquid biopsy biomarkers with high efficacy could be a promising ... -
In vitro antimycobacterial activity of medicinal plants Lantana camara, Cryptolepis sanguinolenta, and Zanthoxylum leprieurii
(Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2022)Background: Imperative need exists to search for new anti-TB drugs that are safer, and more effective against drug-resistant strains. Medicinal plants have been the source of active ingredients for drug development. However, ... -
Effects of season and agro-ecological zone on the microbial quality of raw milk along the various levels of the value chain in Uganda
(Tropical Animal Health and Production, 2008-11-19)Dairy production in Uganda is pasture based and traditional Ankole cattle make up 80% of the cattle herd, reared in both pastoral and agropastoral ecological zones. Regardless of the zone, milk quality is lowest in production ... -
Cucumeropsis mannii seed oil (CMSO) ameliorates adipokines dysfunction and dyslipidemia in male Wistar rats exposed to Bisphenol-A
(BioRxiv, 2022)Bisphenol-A (BPA) and its analog are extensively utilized in the production of plastics which are rather ubiquitous in our environment. At high temperatures, BPA is leached into water and food packed in plastic containers. ... -
CRISPR/Cas9 and next generation sequencing in the personalized treatment of Cancer
(Molecular Cancer, 2022)Background: Cancer is caused by a combination of genetic and epigenetic abnormalities. Current cancer therapies are limited due to the complexity of their mechanism, underlining the need for alternative therapeutic approaches. ...