Faculty of Medicine: Recent submissions
Now showing items 1261-1280 of 1992
-
Adolescent Abstinence and Unprotected Sex in CyberSenga, an Internet-Based HIV Prevention Program: Randomized Clinical Trial of Efficacy
(PLoS ONE, 2013)Context: Cost-effective, scalable programs are urgently needed in countries deeply affected by HIV. Methods: This parallel-group RCT was conducted in four secondary schools in Mbarara, Uganda. Participants were 12 years ... -
Acute and sub-acute toxicity of Echinops kebericho decoction in rats
(BMC Complementary Medicine and Therapies, 2020)Background: Echinops kebericho is widely used for treatment of a variety of diseases including infectious, noninfectious disease and fumigation during child birth. Antibacterial, antimalarial, anti-leshimania, anti-diarrheal ... -
A combination SMS and transportation reimbursement intervention to improve HIV care following abnormal CD4 test results in rural Uganda: a prospective observational cohort study
(BMC medicine, 2015)Background: Up to 50 % of HIV-infected persons in sub-Saharan Africa are lost from care between HIV diagnosis and antiretroviral therapy (ART) initiation. Structural barriers, including cost of transportation to clinic and ... -
Needle-stick injuries in an Ugandan teaching hospital
(Annals of Tropical Medicine & Parasitology, 2002)The on-going HIV epidemic has generally increased fear of needle-stick injuries (NSI) and renewed interest in the problem such injuries pose in Africa. The aims of the present study were to evaluate the frequency of NSI, ... -
Childhood bacterial meningitis in Mbarara Hospital, Uganda: antimicrobial susceptibility and outcome of treatment.
(African Health Sciences, 2001)Background: The recommended antibiotic treatment of bacterial meningitis has come under scrutiny following frequent reports of in-vitro resistance by the common causative organisms to penicillin and chloramphenicol. Objective: ... -
Antipyretic and Antinociceptive Properties of the Aqueous Extract and Saponin from an Edible Vegetable- Vernonia Amygdalina Leaf
(African Journal of food, agriculture, nutrition and development, 2013)Vernonia amygdalina is commonly used for food and health purposes. The processing of the leaf for food is usually aimed at removing bitter tasting principles like saponins. This study was designed to determine the antipyretic ... -
Antibacterial Activities of Echinops kebericho Mesfin Tuber Extracts and Isolation of the Most Active Compound, Dehydrocostus Lactone
(Frontiers in Pharmacology, 2021-01-25)Echinops kebericho Mesfin is traditionally used for the treatment of various infectious diseases. This study investigated antibacterial activity of the essential oil (EO) and the different fractions of ethanol extract. The ... -
Anatomical variation and distribution of the vagus nerve in the esophageal hiatus: a cross‑sectional study of post‑mortem cases in Uganda
(Surgical and Radiologic Anatomy, 2021)Purpose: Vagus nerve injuries during gastroesophageal surgery may cause significant symptoms due to loss of vagal anti-inflammatory and neuromodulator function. Many previous studies have shown high anatomical variability ... -
Affordable medical technologies: bringing Value-Based Design into global health
(BMJ Innovations, 2016)The implementation of the Affordable Care Act (ACA) has spurred a renewed focus on the concept of value, or health outcome per cost expended. Though interventions have generally centered around insurance reform and healthcare ... -
Adverse childhood experiences, alcohol consumption, and the modifying role of social participation: population-based study of adults in southwestern Uganda
(SSM-mental health, 2022)Background: Adverse childhood experiences (ACEs) include multiple forms of child maltreatment, including abuse and neglect, as well as other forms of household dysfunction. Studies from Uganda have revealed a high prevalence ... -
Changes in food insecurity, nutritional status, and physical health status after antiretroviral therapy initiation in rural Uganda
(J Acquir Immune Defic Syndr. 2012 October 1; 61(2): 179–186. doi:10.1097/QAI.0b013e318261f064., 2012)Objective To investigate whether time on antiretroviral treatment (ART) is associated with improvements in food security and nutritional status, and the extent to which associations are mediated by improved physical health ... -
Chemical constituents and evidence-based pharmacological properties of Physalis peruviana L.: An overview
(Journal of Herbmed Pharmacology, 2021-01-21)Physalis peruviana L. is among plant species possessing evident nutritional, nutraceutical, and commercial interests. This review highlights the complexity of the chemical composition supporting the multiple pharmacotherapeutic ... -
Changes in Immune Activation During Pregnancy and the Postpartum Period in Treated HIV Infection .
(Hivma, 2021-05-12)Background. Pregnant women with HIV (PWWH) have high postpartum morbidity and mortality from infections like tuberculosis. Immunologic changes during pregnancy and postpartum periods may contribute to these risks, particularly ... -
Caregiver Perceptions and Motivation for Disclosing or Concealing the Diagnosis of HIV Infection to Children Receiving HIV Care in Mbarara, Uganda: A Qualitative Study
(2014-03-25)Background: Disclosure of the diagnosis of HIV to HIV-infected children is challenging for caregivers. Despite current recommendations, data suggest that levels of disclosure of HIV status to HIV-infected children receiving ... -
Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?
(World journal of pharmacology,, 2014)Artemisinin from the plant Artemisia annua (A. annua) L., and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in ... -
Acute and sub-acute oral toxicity of aqueous whole leaf and green rind extracts of Aloe vera in Wistar rats
(BMC complementary medicine and therapies, 2022)Background: Several local communities in Central, Western, Eastern, and Northern regions of Uganda have been using the whole leaf extracts of Aloe vera (L.) Burm. f. (Asphodelaceae) in the treatment of various ailments. ... -
Inflammatory biomarkers prior to antiretroviral therapy as prognostic markers of 12-month mortality in South Africa and Uganda
(AIDS, 2019)Objective: The aim of this study was to determine the utility of biomarkers of immune activation, systemic inflammation and coagulopathy prior to antiretroviral therapy to predict mortality during the first year of ... -
Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5
(PLoS pathogens, 2020)HIV Nef counteracts cellular host restriction factors SERINC3 and SERINC5, but our understanding of how naturally occurring global Nef sequence diversity impacts these activities is limited. Here, we quantify SERINC3 and ... -
Timing of Antiretroviral Therapy and Systemic Inflammation in Sub-Saharan Africa: Results From the META Longitudinal Cohort Study
(The Journal of infectious diseases, 2019)Chronic inflammation predicts complications in persons with human immunodeficiency virus infection. We compared D-dimer, soluble CD14, and interleukin 6 levels before and 12 months after antiretroviral therapy (ART) ... -
High acceptability for cell phone text messages to improve communication of laboratory results with HIV-infected patients in rural Uganda: a cross-sectional survey study
(BMC medical informatics and decision making, 2012)Background: Patient-provider communication is a major challenge in resource-limited settings with large catchment areas. Though mobile phone usership increased 20-fold in Africa over the past decade, little is known about ...