Faculty of Medicine: Recent submissions
Now showing items 1461-1480 of 1992
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Efforts towards the development of new pediatric sepsis definitions
(Pediatric critical care medicine, 2020-05) -
Effect of high-dose rifampicin on efavirenz pharmacokinetics: drug–drug interaction randomized trial
(Journal of Antimicrobial Chemotherapy, 2020-01)Background: High-dose rifampicin is considered to shorten anti-TB treatment duration but its effect on antiretroviral metabolism is unknown. Objectives: To assess the effect of doubling the rifampicin dose (to 20 mg/kg/day, ... -
Effect of age at initiation of antiretroviral therapy on treatment outcomes; A retrospective cohort study at a large HIV clinic in southwestern Uganda
(PLOS ONE, 2018-08)Background: The prevalence of HIV infection among older persons is increasing yet older age at initiation of antiretroviral therapy (ART) may be associated with poorer treatment outcomes including mortality. However, ... -
Efficacy of Commercially Used Antibacterial Agents against Oral Bacteria Associated with HIV/AIDS Patients in South Western Uganda
(British Journal of Pharmaceutical Research, 2017-05)Aims: This was to determine efficacy and resistance profiles against commonly used commercial antibacterial agents in Uganda in the management of oral pathogens in HIV/AIDS patients. Study Design: This was an experimental ... -
Drugs in Clinical Practice from Toxic Plants and Phytochemicals
(Poisonous Plants and Phytochemicals in Drug Discovery, 2020) -
Retention in HIV care and associated factors among youths aged 15–24 years in rural southwestern Uganda
(BMC Public Health, 2021)Background: Retention in HIV care contributes to antiretroviral therapy adherence, which is a key factor for improved treatment outcomes and prevention of drug resistance. However, HIV treatment among the youths is ... -
Drugs for some but not all: inequity within community health worker teams during introduction of integrated community case management
(BMC health services research, 2014)Background: The Ugandan health system now supports integrated community case management (iCCM) by community health workers (CHWs) to treat young children ill with fever, presumed pneumonia, and diarrhea. During an iCCM ... -
Resistance, Minimum Inhibitory and Bactericidal Concentration Profiles of Oral Bacteria from HIV/AIDS Patients in South Western Uganda
(British Journal of Medicine & Medical Research, 2016)Background: The development of drug resistance is a major challenge in the management of microbial infections especially in immune-compromised (HIV/AIDS) patients. Objective: This was to assess levels of antibacterial ... -
Drug-Resistant Tuberculosis Presenting as a Testicular Mass: A Case Report
(International Medical Case Reports Journal, 2021)Anti-microbial resistance is a growing threat to the effective treatment of various pathogens.1 In particular, drug-resistant tuberculosis (DR-TB) is the leading contributor to antimicrobial resistance-related death globally, ... -
Lung function and atherosclerosis: a cross‑sectional study of multimorbidity in rural Uganda
(BMC Pulmonary Medicine, 2022)Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of global mortality. In high-income settings, the presence of cardiovascular disease among people with COPD increases mortality and complicates ... -
Resistance pattern of infected chronic wound isolates and factors associated with bacterial resistance to third generation cephalosporins at Mbarara Regional Referral Hospital, Uganda
(Plos one, 2021)Background The objectives of this study were; (I) to determine the proportion of pathogens isolated from patients with infected chronic wounds in the surgical ward of MRRH that are resistant to the third-generation ... -
Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?
(World journal of pharmacology, 2014-12)Artemisinin from the plant Artemisia annua (A. annua) L, and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in ... -
Low Resistance to First and Second Line Anti- Tuberculosis Drugs among Treatment Naive Pulmonary Tuberculosis Patients in Southwestern Uganda
(PLoS ONE, 2015-02-06)Background: There are limited data on region-specific drug susceptibility of tuberculosis (TB) in Uganda. We performed resistance testing on specimens collected from treatment-naive patients with to provide data to guide ... -
Loss to follow-up and associated maternal factors among HIV-exposed infants at the Mbarara Regional Referral Hospital, Uganda: a retrospective study
(BMC Infectious Diseases, 2020-03-19)Background: Loss to follow-up (LTFU) deprives HIV-exposed infants the lifesaving care required and results in exposing HIV free infants to virus requisition risk. We aimed to determine the rate of LTFU, postnatal mother-to ... -
Longitudinal assessment of associations between food insecurity, antiretroviral adherence and HIV treatment outcomes in rural Uganda
(AIDS, 2015-11-02)Introduction: Food insecurity is a potentially important barrier to the success of antiretroviral treatment (ART) programs in resource-limited settings. We undertook a longitudinal study in rural Uganda to estimate the ... -
Pediatric sepsis in the developing world:Challenges in defining sepsis and issues in post-discharge mortality
(2012)Sepsis represents the progressive underlying inflammatory pathway secondary to any infectious illness, and ultimately is responsible for most infectious disease-related deaths. Addressing issues related to sepsis has ... -
Pediatric out-of-hospital deaths following hospital discharge
(African Health Sciences, 2016)Background: Out-of-hospital death among children living in resource poor settings occurs frequently. Little is known about the location and circumstances of child death following a hospital discharge. Objectives: This ... -
Maternal health services for pregnant adolescent girls in Uganda: Barriers and Opportunities
(Research square, 2020-04-13)Background: Globally, adolescent pregnancy is one of the major areas of concern. Over 16 million girls aged between 15-19 years give birth, while over 1 million become pregnant before 15 years, most of who are in Sub-Saharan ... -
Malaria is an uncommon cause of adult sepsis in south-western Uganda
(Malaria Journal, 2013-05-01)Background: Malaria is often considered a cause of adult sepsis in malaria endemic areas. However, diagnostic limitations can make distinction between malaria and other infections challenging. Therefore, the objective of ... -
Lessons Learned From and Future Opportunities for Global Health Endeavors by 2 Academic Gastroenterology Units
(Gastroenterology, 2019-11-01)