Faculty of Medicine: Recent submissions
Now showing items 1501-1520 of 1992
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Rate of clearance of infection is independently associated with clinical outcome in HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients
(Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, 2009)Background—Progress in therapy of cryptococcal meningitis has been slow because of the lack of a suitable marker of treatment response. Previously, we demonstrated the statistical power of a novel endpoint, the rate of ... -
Rare Late Presentation of Severe Congenital Hemophilia A in an Adult Ugandan Soldier Following Elective Circumcision
(Authorea Preprints, 2021)Severe hemophilia symptoms usually start in infancy. Affected individuals require coagulation factor routinely to live a normal life. A 25-year old active-duty soldier was diagnosed with severe congenital hemophilia A after ... -
Intimate Partner Violence Disclosure and Associated Factors Among Pregnant Women Attending a City Hospital in South-Western Uganda: A Cross-sectional Study
(Research square, 2021-09-09)Background: Pregnancy-associated Intimate Partner violence (IPV) is a significant public health problem in Uganda impacting on maternal and newborn health outcomes adversely. However, IPV disclosure and related factors ... -
Rapid, remote education for point-of-care ultrasound among non-physician emergency care providers in a resource limited setting
(African Journal of Emergency Medicine, 2019)Introduction: Access to high-quality emergency care in low- and middle-income countries (LMIC) is lacking. Many countries utilise a strategy known as “task-shifting” where skills and responsibilities are distributed in ... -
Internet Use among Ugandan Adolescents: Implications for HIV Intervention
(PLoS Medicine, 2006-11-07)Background: The Internet is fast gaining recognition as a powerful, low-cost method to deliver health intervention and prevention programs to large numbers of young people across diverse geographic regions. The feasibility ... -
Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study
(The Lancet Infectious Diseases, 2017-09-14)Background: WHO recommends Xpert MTB/RIF as initial diagnostic testing for tuberculous meningitis. However, diagnosis remains difficult, with Xpert sensitivity of about 50–70% and culture sensitivity of about 60%. We ... -
Quality Control for the Safety of Natural Products
(Poisonous Plants and Phytochemicals in Drug Discovery, 2020)The World Health Organization (WHO) has defined a medicinal plant as any plant in which one or more of its parts consists of substances that are used for the synthesis of beneficial drugs [1]. These plants need to be studied ... -
Internalized Stigma, Social Distance, and Disclosure of HIV Seropositivity in Rural Uganda
(Annals of Behavioral Medicine, 2013-05-21)Background: HIV is highly stigmatized, compromising both treatment and prevention in resource-limited settings. Purpose: We sought to study the relationship between internalized HIV-related stigma and serostatus disclosure ... -
Individual and health facility factors and the risk for obstructed labour and its adverse outcomes in south-western Uganda
(BMC pregnancy and childbirth, 2011)Background: Obstructed labour is still a major cause of maternal morbidity and mortality and of adverse outcome for newborns in low-income countries. The aim of this study was to investigate the role of individual and ... -
Psychosocial challenges facing women living with HIV during the perinatal period in rural Uganda
(PloS one, 2017)The complexities of navigating pregnancy while living with HIV predispose women to additional stress. Finding ways to minimize psychosocial challenges during the perinatal period may maximize the well-being of mothers ... -
Independent Association between Rate of Clearance of Infection and Clinical Outcome of HIV-Associated Cryptococcal Meningitis: Analysis of a Combined Cohort of 262 Patients
(Clinical infectious diseases,, 2009)Background: Progress in therapy for cryptococcal meningitis has been slow because of the lack of a suitable marker of treatment response. Previously, we demonstrated the statistical power of a novel endpoint, the rate of ... -
Projection neurons in the cortex and hippocampus: differential effects of chronic khat and ethanol exposure in adult male rats
(Journal of Experimental Pharmacology, 2016)Background: Recent evidence suggests that many individuals who chew khat recreationally also drink ethanol to offset the stimulating effect of khat. The objective of this study was to describe the separate and interactive ... -
Prognostic implications of baseline anaemia and changes in haemoglobin concentrations with amphotericin B therapy for cryptococcal meningitis
(HIV medicine, 2017)Objectives Anaemia represents a common toxicity with amphotericin B-based induction therapy in HIVinfected persons with cryptococcal meningitis. We sought to examine the impact of amphotericinrelated anaemia on ... -
Prevention of cardiovascular disease among people living with HIV in sub-Saharan Africa
(Progress in cardiovascular diseases, 2020)As longevity has increased for people living with HIV (PLWH) in the United States and Europe, there has been a concomitant increase in the prevalence of cardiovascular disease (CVD) risk factors and morbidity in this ... -
Prevalence, Morphological Classification,And Factors Associated With Anemia Among Pregnant Women Accessing Antenatal Clinic At Itojo Hospital, South Western Uganda
(Journal of blood medicine, 2019)Purpose: The study aimed to determine the prevalence, morphological classification, and risk factors of anemia among pregnant mothers attending antenatal clinic at Itojo hospital, Ntungamo district, southwestern Uganda. ... -
Increased Systemic Inflammation and Gut Permeability Among Women With Treated HIV Infection in Rural Uganda
(The Journal of Infectious Diseases, 2018-04-28)In a cohort of human immunodeficiency virus (HIV)–infected individuals and age- and sex-matched HIV-uninfected comparators, we assessed soluble CD14 (sCD14), sCD163, interleukin 6, intestinal fatty acid binding protein ... -
Prevalence, characteristics and predicting risk factors of adverse drug reactions among hospitalized older adults: A systematic review and meta-analysis
(SAGE Open Medicine, 2021)Background: Occurrence of adverse drug reactions is a major global health problem mostly affecting older adults. Identifying the magnitude and predictors of adverse drug reactions is crucial to developing strategies to ... -
Regulation of medical diagnostics and medical devices in the East African community partner states
(BMC health services research, 2014)Background: Medical devices and in vitro diagnostic tests (IVD) are vital components of health delivery systems but access to these important tools is often limited in Africa. The regulation of health commodities by National ... -
Registration and local production of essential medicines in Uganda
(Journal of pharmaceutical policy and practice, 2020)Background: Universal access to high quality essential medicines is critical to sustainable development (SDG 3.8). However low- and middle-income countries struggle to ensure access to all medicines on their national ... -
Prevalence of Severe Neurocognitive Impairment and Its Association with Socio-Demographics and Functionality Among Ugandan Older Persons: A Hospital-Based Study
(Clinical Interventions in Aging, 2021)Background: The prevalence of neurocognitive disorders, especially dementia, is rising due to an increase in longevity. Early detection and diagnosis of neurocognitive impairments are important for early interventions and ...