Faculty of Medicine: Recent submissions
Now showing items 1541-1560 of 1992
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Determinants of two-year mortality among HIV positive patients with Cryptococcal meningitis initiating standard antifungal treatment with or without adjunctive dexamethasone in Uganda
(PLOS NEGLECTED TROPICAL DISEASES, 2020-11-30)Globally, early initiation of antiretroviral therapy for HIV led to a reduction in the estimated mortality from cryptococcal meningitis (CCM) from 624,700 in 2009 to 181,100 in 2014. However, CCM remains one of the leading ... -
Determinants of Mortality in a Combined Cohort of 501 PatientsWith HIV-Associated Cryptococcal Meningitis: Implications for Improving Outcomes
(Clinical Infectious Diseases, 2013-12-06)Background: Cryptococcal meningitis (CM) is a leading cause of death in individuals infected with human immunodeficiency virus (HIV). Identifying factors associated with mortality informs strategies to improve outcomes. Methods: ... -
Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study
(The Lancet infectious diseases, 2020)Introduction: Tuberculous meningitis accounts for 1–5% of tuberculosis cases. Diagnostic delay contributes to poor outcomes. We evaluated the performance of the new Xpert MTB/RIF Ultra (Xpert Ultra) for tuberculous meningitis ... -
Will district health centres use preloaded cell phones for pre-referral phone calls for women in labour: a randomized pilot study at Mbarara Regional Referral Hospital in southwest Uganda
(Canadian Journal of Public Health, 2019-05-28) -
Determinants of loss to follow-up among HIV positive patients receiving antiretroviral therapy in a test and treat setting: A retrospective cohort study in Masaka, Uganda
(PLOS ONE, 2020-04-07)Background: Retaining patients starting antiretroviral therapy (ART) and ensuring good adherence remain cornerstone of long-term viral suppression. In this era of test and treat (T&T) policy, ensuring that patients starting ... -
Heterogeneous decrease in malaria prevalence in children over a six-year period in south-western Uganda
(Malaria Journal, 2011)Background: Malaria is a major public health problem, especially for children. However, recent reports suggest a decline in the malaria burden. The aim of this study was to assess the change in the prevalence of malaria ... -
Whole genome sequences of multi-drug resistant Escherichia coli isolated in a Pastoralist Community of Western Uganda: Phylogenomic changes, virulence and resistant genes
(PLoS ONE, 2020-05-29)Background: The crisis of antimicrobial resistance is already here with us, affecting both humans and animals alike and very soon, small cuts and surgeries will become life threatening. This study aimed at determine the ... -
Health‑related quality of life among patients with bipolar disorder in rural southwestern Uganda: a hospital based cross sectional study
(Health and Quality of Life Outcomes,, 2021)Background: Bipolar disorder is a psychiatric disorder that alters mood and affects over 55 million people globally with an estimated lifetime prevalence of approximately 0.8–1.1%. In Africa, the lifetime prevalence of the ... -
Health-profession students’ teaching and learning expectations in Ugandan medical schools: pre- and postcommunity placement comparison
(Advances in Medical Education and Practice, 2015)Purpose: The benefits of community-based medical education for both students and teachers are becoming increasingly clear. However, there is paucity of information about the importance of incorporating students’ thoughts ... -
Detection of Plasmodium Species by High-Resolution Melt Analysis of DNA from Blood Smears Acquired in Southwestern Uganda
(Journal of Clinical Microbiology, 2017-10-02)Microscopic diagnosis of malaria using Giemsa-stained blood smears is the standard of care in resource-limited settings. These smears represent a potential source of DNA for PCR testing to confirm Plasmodium infections or ... -
Patient experiences and perspectives on Hypertension at a major referral hospital in rural southwestern Uganda
(2020)Objectives Novel care models are needed to address the large burden of hypertension globally. We aimed to explore how patients in rural Uganda experience and perceive hypertension in order to understand factors that ... -
Vitamin K Deficiency Bleeding and Early Infant Male Circumcision in Africa
(Obstetrics and gynecology, 2013-08)Background: Early infant (1–60 days of life) male circumcision is being trialed in Africa as a human immuno-deficiency virus prevention strategy. Post circumcision bleeding is particularly concerning where most infants are ... -
Detection of Mycobacterium Tuberculosis Multiple Strains in Sputum Samples from Patients with Pulmonary Tuberculosis in South Western Uganda using MIRU-VNTR
(Research Square, 2021-09-09)Infections with multiple strains of Mycobacterium tuberculosis are now widely recognized as a common occurrence. Identification of patients infected with multiple strains, provides both insight into the disease dynamics ... -
Validity of hemoglobin A1c for diagnosing diabetes among people with and without HIV in Uganda
(International journal of STD & AIDS, 2019)Sub-Saharan Africa (SSA) is facing a growing co-epidemic of chronic HIV infection and diabetes. Hemoglobin A1c (A1c) may underestimate glycemia among people living with HIV (PLWH). We estimated the validity of A1c to ... -
Healthcare providers and caregivers’ perspectives on factors responsible for persistent malnutrition of under 5 children in Buhweju district, South Western Uganda; a phenomenological qualitative study
(BMC public health, 2021)Background: Unacceptably high levels of childhood malnutrition have been registered in all regions of Uganda over the years. Buhweju district alone contributed 46% prevalence of childhood malnutrition to the 47.8% estimated ... -
Designing and evaluating a novel mobile application for Helping Babies Breathe skills retention in Uganda: comparative study protocol
(BMJ Paediatrics open, 2019-08)Introduction: Over 600 000 newborns die each year of intrapartum-related events, many of which are preventable in the presence of skilled birth attendants. Helping Babies Breathe (HBB) is a neonatal resuscitation training ... -
Validity and Reliability of a Self-Reported Measure of Antihypertensive Medication Adherence in Uganda
(PLoS ONE, 2016-07-01)Background: The Morisky Medication Adherence scale (MMAS-8) is a widely used self-reported measure of adherence to antihypertensive medications that has not been validated in hypertensive patients in sub-Saharan ... -
Health information seeking among Mbararan adolescents: results from the Uganda Media and You survey
(Health education research, 2008)To maximize scarce intervention dollars, pediatricians and other adolescent health professionals must position health promotion efforts in mediums that most effectively reach youth. This may be especially true in ... -
Validation of the Intracerebral Hemorrhage Score in Uganda A Prospective Cohort Study
(Stroke, 2022-01-06)Background and Purpose: Rates of intracerebral hemorrhage (ICH) are estimated to be highest globally in sub-Saharan Africa. However, outcomes of ICH are poorly described and standard prognostic markers for ICH have not ... -
Pan-resistome characterization of uropathogenic escherichia coli and klebsiella pneumoniae strains circulating in Uganda and Kenya, isolated from 2017–2018
(MDPI, 2021-12-17)Urinary tract infection (UTI) develops after a pathogen adheres to the inner lining of the urinary tract. Cases of UTIs are predominantly caused by several Gram-negative bacteria and account for high morbidity in the ...