Faculty of Medicine: Recent submissions
Now showing items 181-200 of 1970
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Trust in Medical Research: A comparative study among Patients at a Regional Referral Hospital and Community Members in Lira District, Northern Uganda
(Journal of Empirical Research on Human Research Ethics, 2024)Events such as the Tuskegee syphilis study shaped how the public perceives and trusts medical research globally. However, few studies have examined trust in medical research in developing countries. We tested the hypothesis ... -
Adaptation of the Client Diagnostic Questionnaire for East Africa
(PLOS Global Public Health, 2024)Research increasingly involves cross-cultural work with non-English-speaking populations, necessitating translation and cultural validation of research tools. This paper describes the process of translating and criterion ... -
Association between smoking and lack of HIV virological suppression in a cross-sectional study of persons with HIV on antiretroviral therapy in Uganda
(PLoS ONE, 2024)Background: Smoking and alcohol use frequently co-occur and are the leading causes of preventable death in sub-Saharan Africa (SSA) and are common among people living with HIV (PLWH). While alcohol use has been shown to ... -
Real-world use and outcomes of dolutegravir-containing antiretroviral therapy in HIV and tuberculosis co-infection: a site survey and cohort study in sub-Saharan Africa
(Journal of the International AIDS Society, 2022)Introduction: Dolutegravir is being scaled up globally as part of antiretroviral therapy (ART), but for people with HIV and tuberculosis co-infection, its use is complicated by a drug–drug interaction with rifampicin ... -
A prospective ascertainment of cancer incidence in sub- Saharan Africa: The case of Kaposi sarcoma
(Cancer medicine, 2016)In resource- limited areas, such as sub- Saharan Africa, problems in accurate cancer case ascertainment and enumeration of the at- risk population make it difficult to estimate cancer incidence. We took advantage of a large ... -
The Drinkers’ Intervention to Prevent Tuberculosis (DIPT) trial among heavy drinkers living with HIV in Uganda: study protocol of a 2×2 factorial trial
(Trials, 2021)Background: The risk of tuberculosis (TB) is high among people with HIV (PWH). Heavy alcohol drinking independently increases TB risk and approximately 25% of PWH globally engage in heavy drinking. While isoniazid (INH) ... -
The impact of HIV on fertility aspirations in Uganda.
(Population Study Center,, 2011)This paper reports on a study of whether a women’s personal HIV status, the presence of an HIV+ child in the household, or the presence of foster children in the household, has a measureable impact on a woman’s desire for ... -
Toward an Understanding of Disengagement from HIV Treatment and Care in Sub-Saharan Africa: A Qualitative Study
(PLoS medicine, 2013)Background: The rollout of antiretroviral therapy in sub-Saharan Africa has brought lifesaving treatment to millions of HIVinfected individuals. Treatment is lifelong, however, and to continue to benefit, patients must ... -
Traditional healer-delivered point-of-care HIV testing versus referral to clinical facilities for adults of unknown serostatus in rural Uganda: a mixed-methods, cluster-randomised trial
(The Lancet Global Health, 2021)Background: HIV counselling and testing are essential to control the HIV epidemic. However, HIV testing uptake is low in sub-Saharan Africa, where many people use informal health-care resources such as traditional healers. ... -
Tuberculin skin test positivity among HIVinfected alcohol drinkers on antiretrovirals in south-western Uganda
(PloS one, 2020)Background: Tuberculosis (TB) is the leading cause of death among people living with HIV (PLWH), and current evidence suggests that heavy alcohol users have an increased risk of developing TB disease compared to non-drinkers. ... -
Unhealthy alcohol use and intimate partner violence among men and women living with HIV in Uganda.
(BMC public health, 2022)Background: Intimate partner violence (IPV) and alcohol use are interrelated public health issues. Heavy and frequent alcohol use increase the risk of IPV, but the relationship between alcohol use and IPV (including recent ... -
Virological Non-Suppression, Non-Adherence and the Associated Factors Among People Living with HIV on Dolutegravir-Based Regimens: A Retrospective Cohort Study
(HIV/AIDS - Research and Palliative Care, 2024)Background: HIV is one of the leading causes of morbidity and mortality, with 39.0 million people living with HIV worldwide, 25.6 million of whom reside in the African region. Highly active anti-retroviral therapy (HAART) ... -
Impact of the Mbarara University of Science and Technology residency training on increasing access to specialty care workforce
(PLOS Global Public Health, 2024)Graduate tracer studies provide an avenue for assessing the impact of residency training on the distribution and access to specialty care and exploring job and professional satisfaction of alumnus. This study examined how ... -
Development and Validation of the East Africa Alcohol Expectancy Scale (AFEXS)
(Journal of studies on alcohol and drugs, 2015)Objective: The purpose of this study was to develop and validate the East Africa Alcohol Expectancy Scale (AFEXS), a measure of alcohol expectancies for use with HIV-positive adults in East Africa. Method: The study was ... -
Quantifying the burden of cardiovascular diseases among people living with HIV in sub-Saharan Africa: Findings from a modeling study for Uganda
(Journal of Global Health Reports, 2020)Background: The burden of non-communicable diseases (NCDs) is rapidly increasing in low- and middle-income countries, but remains largely unknown among people living with HIV (PLWH) in most sub-Saharan African countries. ... -
Prevalence of elevated liver transaminases and their relationship with alcohol use in people living with HIV on anti-retroviral therapy in Uganda
(PloS one, 2021)Background: Isoniazid preventive therapy (IPT) reduces tuberculosis reactivation and mortality among persons living with HIV (PLWH), yet hepatotoxicity concerns exclude “regular and heavy alcohol drinkers” from IPT. We ... -
Post-traumatic stress disorder among persons with HIV who engage in heavy alcohol consumption in southwestern Uganda
(BMC psychiatry, 2021)Background: We aimed to describe the prevalence of PTSD symptoms and its associated factors in persons living with HIV (PLWH) in Uganda who engage in heavy alcohol use. Methods: We analyzed baseline data from the Drinkers ... -
Patient choice improves self-efficacy and intention to complete tuberculosis preventive therapy in a routine HIV program setting in Uganda
(PLoS One, 2021)A 12-dose weekly regimen of rifapentine plus isoniazid (3HP) is recommended for the prevention of active tuberculosis (TB); however, it is unclear whether 3HP should be provided by directly observed therapy (DOT) or ... -
Late disease stage at presentation to an HIV clinic in the era of free antiretroviral therapy in sub-Saharan Africa
(JAIDS Journal of Acquired Immune Deficiency Syndromes, 2009)Background: Access to free antiretroviral therapy (ART) in sub-Saharan Africa has been steadily increasing, and the success of large-scale ART programs depends on early initiation of HIV care. However, little is known about ... -
Interventions to Increase HIV Testing Uptake in Global Settings
(Current HIV/AIDS Reports, 2022)Purpose of Review: HIV testing is the critical first step to direct people living with HIV (PLWH) to treatment. However, progress is still being made towards the UNAIDS benchmark of 95% of PLWH knowing their status by 2030. ...