Faculty of Medicine: Recent submissions
Now showing items 461-480 of 1979
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Linkage to HIV Care Following HIV Self‑testing Among Men: Systematic Review of Quantitative and Qualitative Studies from Six Countries in Sub‑Saharan Africa
(AIDS and Behavior, 2023)Gender disparities are pervasive throughout the HIV care continuum in sub-Saharan Africa, with men testing, receiving treatment, and achieving viral suppression at lower rates, and experiencing mortality at higher rates, ... -
Prevalence of dementia and its association with central nervous system infections among older persons in northern Uganda: crosssectional community-based study
(BMC geriatrics, 2023-09)Background: Dementia is a condition in which there is deterioration in cognitive function beyond what might be expected from the usual consequence of biological aging. Few studies have been conducted on the prevalence of ... -
The role of emergency medicine interest groups in the development of emergency medicine: A case of Mbarara University of Science and Technology—Emergency Medicine Interest Group (MUST-EMIG) in Uganda
(African Journal of Emergency Medicine, 2023)Introduction: Emergency medicine (EM) is a new specialty in Uganda. There is no current formal EM undergraduate curriculum. The Mbarara University of Science and Technology Emergency Medicine Interest Group (MUST-EMIG) was ... -
Suberosin Alleviates Thiazolidinedione‑Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4‑LPCAT3 and PI3K‑AKT Signaling Pathways
(Cardiovascular Toxicology, 2023)Thiazolidinediones are useful antidiabetic medications. However, their use is associated with adverse side effects like edema, heart failure and bone fractures. In this study, we investigated the anti-ferroptosis effects ... -
Systematic Review of mHealth Interventions for Adolescent and Young Adult HIV Prevention and the Adolescent HIV Continuum of Care in Low to Middle Income Countries
(AIDS and Behavior, 2023)Adolescents and young adults (AYA) in low to middle income countries (LMIC) have poorer outcomes along each step in the HIV continuum of prevention and care compared to younger children or older adults. The use of mHealth ... -
Treatment outcomes of alcohol use disorder by traditional medicine practitioners using plant derivatives in southwestern Uganda: findings from in-depth interviews
(Frontiers in Psychiatry, 2023-08-31)Background: Globally, 5.1% of the global burden of disease and injury is attributable to alcohol in addition to its significant negative socio-economic impact. Uganda is ranked among the highest alcohol consuming countries ... -
Estimating cancer incidence in Uganda: a feasibility study for periodic cancer surveillance research in resource limited settings
(BMC cancer, 2023)Background Population based cancer registries (PBCRs) are accepted as the gold standard for estimating cancer incidence in any population. However, only 15% of the world’s population is covered by high quality cancer ... -
Effect of the COVID-19 lockdown on the HIV care continuum in Southwestern Uganda: A time series analysis
(Plos one, 2023)Introduction: In Uganda, COVID-19 lockdown policies curbed the spread of SARS-CoV-2, but their effect on HIV care is poorly understood. Objectives: We examined the effects of COVID-19 lockdown policies on ART initiation, ... -
Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis
(Journal of Young Pharmacists, 2023)Background: In this present work, methanol extracts of the leaves and flowers of Salvia officinalis Linn. (MES) and Rosmarinus officinalis Linn. (MER) were examined for their potential anti-aging and antioxidant properties ... -
A rare presentation of a giant malignant melanoma in a 67 year old female Ugandan: A case report
(International Journal of Surgery Case Reports, 2023)Introduction and importance: Malignant melanoma (MM) is a skin cancer whose incidence is alarmingly increasing globally. However, the public, especially among the black population, still has very little knowledge about ... -
Understanding Patients’ Experiences with a Brief Alcohol Reduction Intervention among People Living with HIV in Uganda: A Qualitative Study
(Substance Use & Misuse, 2023)Background: Brief alcohol reduction interventions for people living with HIV (PLWH) have resulted in mixed findings with some studies showing null or limited treatment effects. To better understand factors that may contribute ... -
Investigating Metabolic and Molecular Ecological Evolution of Opportunistic Pulmonary Fungal Coinfections: Protocol for a Laboratory-Based Cross-Sectional Study
(JMIR Research Protocols, 2023)Background: Fungal-bacterial cocolonization and coinfections pose an emerging challenge among patients suspected of having pulmonary tuberculosis (PTB); however, the underlying pathogenic mechanisms and microbiome interactions ... -
Frequency, severity, and factors associated with clinically significant drug‑drug interactions among patients with cancer attending Mbarara Regional Referral Hospital Cancer Unit, Uganda
(BMC cancer, 2022)Background: Cancer is a major public health problem with pharmacotherapy being the cornerstone of its management. Cancer patients receive multiple drugs concurrently risking Drug-Drug Interactions (DDIs). DDIs, though ... -
Elucidation of chemical profiles and molecular targets of Mondia whitei leave fractions bioactive as novel therapeutics: an in vitro and in silico assay
(Journal of Genetic Engineering and Biotechnology, 2022)Background: Mondia whitei root is often used in Africa as a local therapeutic agent for libido enhancement. The fractions of the M. whitei leaves (MWL) lack chemical characterization of their bioactive components and ... -
MicroRNA-510-3p and Its Gene Network in the Disease Regulation of Preeclampsia: An Insilico Approach
(Journal of Biological Regulators and Homeostatic Agents, 2023)Background: Preeclampsia (PE) is a major health complication for pregnant women that increases the risk of mortality and morbidity. Knowledge of the complex molecular mechanisms associated with PE is incomplete and methods ... -
Increasing use of interferon gamma release assays among children ≥2 years of age in a setting with low tuberculosis prevalence
(The Pediatric Infectious Disease Journal, 2022)US guidelines recommend interferon gamma release assays (IGRAs) for diagnosis of tuberculosis infection in children. In this retrospective cohort study, IGRA use in children 2–17 years of age increased substantially between ... -
Gender differences in substance use and associated factors among urban refugees in Uganda
(European Journal of Psychotraumatology, 2023)Background: Alcohol and other substances use related problems among refugees is a global public health concern. Although there is substantial research on the use of alcohol and other substances among the refugees, little ... -
TDP-43 and NEAT long non-coding RNA: Roles in neurodegenerative disease
(Frontiers in Cellular Neuroscience, 2022)Understanding and ameliorating neurodegenerative diseases represents a key challenge for supporting the health span of the aging population. Diverse protein aggregates have been implicated in such neurodegenerative disorders, ... -
Corrigendum: TDP-43 and NEAT long non-coding RNA: Roles in neurodegenerative disease
(Frontiers in Cellular Neuroscience, 2022)“Understanding and ameliorating neurodegenerative diseases represents a key challenge for supporting the health span of the aging population. Diverse protein aggregates have been implicated in such neurodegenerative ... -
Cervical amniotic fluid bacterial colonization, antibiotic susceptibility and associated factors among women with premature rupture of membranes at Mbarara Regional Referral Hospital, Southwestern Uganda
(Research square, 2023)Background: Bacterial colonization is a recognized cause of premature rupture of membranes (PROM), a predictor of poor maternal and fetal outcomes. Despite routine use of antibiotics in women with PROM, data on antibiotic ...