Faculty of Medicine: Recent submissions
Now showing items 841-860 of 1988
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Therapeutic potentials of Vachellia nilotica (L.) extracts in Hepatitis C infection: A review
(Scientific African, 2021)Hepatitis C Virus (HCV) infection represents a huge burden on healthcare systems world- wide. Vachellia nilotica ( V. nilotica ) is a widely used plant specie in folk medicine for viral diseases and in some communities for ... -
The anti-nociceptive effects of ethanol extract of aerial parts of Schkuhria pinnata in mice
(Journal of Ethnopharmacology, 2021)Ethnopharmacological relevance: The growing challenge to access conventional analgesics, contraindications, and adverse effects could have led individuals to use Schkuhria pinnata (Lam.) Kuntze ex Thell. (Compositae), as ... -
New Putative Antimicrobial Candidates: In silico Design of Fish-Derived Antibacterial Peptide-Motifs
(Frontiers in Bioengineering and Biotechnology, 2020)Antimicrobial resistance remains a great threat to global health. In response to the World Health Organizations’ global call for action, nature has been explored for novel and safe antimicrobial candidates. To date, fish ... -
Human Health Risk Assessment of Heavy Metals in Kampala (Uganda) Drinking Water
(Journal of Food Research, 2022)Levels of aluminium, arsenic, cadmium, chromium, copper, iron, mercury, manganese, nickel, lead and zinc in tap water, groundwater-fed protected spring and bottled water were determined. The cancer and non-cancer risks ... -
General Extraction, Isolation and Characterization Techniques in Drug Discovery: A Review
(International Journal of Sciences: Basic and Applied Research (IJSBAR), 2018)Extraction, isolation and characterization techniques of compounds from plant tissues are the basic foundations of drug discovery from plants. Research has been conducted using these techniques and publications are available ... -
Fundamental Methods in Drug Permeability, pKa, LogP and LogDx Determination
(Journal of Drug Research and Development, 2018)Potential drug molecular leads from plants are usually tested for their efficacy in bioactivity assays in preclinical trials. This is followed by testing for the properties of the molecular structures, if they can be ... -
Fish Mucus- a Neglected Reservoir For Antimicrobial Peptides
(Asian Journal of Pharmaceutical Research and Development, 2018)Antimicrobial resistance has posed a great global burden, with the fear that by 2050 it would have killed more people than cancer if nothing much is done about it. Alongside several attempts in place, zoo-therapy is becoming ... -
Drug-like properties of anticancer molecules elucidated from Eichhornia crassipes
(Journal of Pharmacognosy and Phytochemistry, 2018)Eichhornia crassipes is reported to have molecules that are active against liver, cervical, breast cancers and melanoma cells. This systematic review was conducted according to Cochrane hand book of systematic review and ... -
D-optimal mixture design optimized solid formulation containing fruits extracts of Momordica charantia and Abelmoschus esculentus
(PLoS ONE, 2022-06-24)Fruit extracts of Momordica charantia L. (Cucurbitaceae) and Abelmoschus esculentus (L.) Moench (Malvaceae) have shown promising antidiabetic activities in clinical trials. However, they remain underutilized due to ... -
Dietary Content and Potential Health Risks of Metals in Commercial Black Tea in Kampala (Uganda)
(Journal of Food Research, 2017)Tea (Camellia sinensis (L.) Kuntze) is among the most widely consumed non-alcoholic beverages. It is a rich source of essential dietary elements mainly potassium and manganese. Tea may also contain toxic metals such as ... -
Chromatographic, Mass and Cytotoxicity analysis of Isolates from Eichhornia crassipes’ Roots and Leaves against HepG2 and MCF7 cell lines
(Cogent Biology, 2021)Cancers remain one of the leading causes of death in the world. However, known conventional cancer medicines remain scarce, expensive and out of reach to many patients. To provide an alternative for the expensive therapies, ... -
Bacterial Cell Envelope Lysis and Hemotoxicity of Peptides Previously isolated From African Catfish, Clarias gariepinus
(East African Science, 2022-06)Background: The skin mucus layer of fish is endowed with biologics including, Antimicrobial peptides (AMPs) that offer a first line of defence against pathogens. Such peptides can either inhibit bacterial growth or completely ... -
A review of breast cancer treatment modalities in uganda - an appraisal of The breast cancer diagnostic process, regulatory approval and supply system of standardized anti-breast cancer medicines
(International Journal of Advanced Research, 2020-02)Breast cancer is the leading cause of cancer death among women and the third incident cancer in the world, contributing 1.7 million of the 17.2 million annual incident cancer cases. For Uganda, breast cancer is the third ... -
Registration, procurement, distribution, and use of misoprostol in Uganda: an interview-based observational study
(The Lancet, 2013)Background: Poor access to essential medicines remains a barrier to improvement of health in low-income countries. The maternal mortality rate from post-partum haemorrhage (PPH) in Uganda is one of the highest in the world. ... -
Prevalence and associated factors of oligohydramnios in pregnancies beyond 36 weeks of gestation at a tertiary hospital in southwestern Uganda
(BMC Pregnancy and Childbirth, 2022)Background: Oligohydramnios is associated with poor maternal and perinatal outcomes. In low-resource countries, including Uganda, oligohydramnios is under-detected due to the scarcity of ultrasonographic services. We ... -
Factors associated with delayed onset of active labor following administration of vaginal Misoprostol among women at Mbarara Regional referral hospital, Uganda: A prospective cohort study
(Research square, 2019)Background: Vaginal misoprostol has been recommended by the World Health Organization as one of the effective methods for induction of labor. Globally 9.6% of all deliveries follow induction of labor. Although the goal of ... -
An Evaluation of Factors Affecting Drug Quality: Evidence from the Antimalarial Market in Uganda
(University of Massachusetts Boston, 2015-10-28)The quality of healthcare, and specifically medicines, is reportedly low in developing countries. We purchase and test 879 antimalarial drugs from 459 outlets in 44 randomly selected parishes (131 villages) in Uganda to ... -
Red blood cell alloimmunization in transfused patients in sub-Saharan Africa: A systematic review and meta-analysis
(Transfusion and Apheresis Science, 2016)Background and objectives: Previous studies of Sub-Saharan Africans show significant alloimmunization to red blood cell (RBC) antigens, but country-specific data are limited. Thus, the aim of this study was to estimate, ... -
Red blood cell alloimmunization from an African perspective
(Current Opinion in Hematology, 2010)Purpose of review: Red blood cell (RBC) alloimmunization occurs when individuals are exposed to erythrocytes that express blood group antigens different from their own. Consequences of alloimmunization include hemolytic ... -
Red blood cell alloimmunization and antigen matching in sickle cell disease – the African perspective
(ISBT Science Series, 2012)In sickle cell disease (SCD), blood transfusion facilitates improved blood and tissue oxygenation, reduces the propensity to sickling by diluting host cells, and suppresses the production of red blood cells (RBCs) containing ...