Mbarara University of Science and Technology Institutional Repository: Recent submissions
Now showing items 161-180 of 3211
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Factors associated with HIV testing among traditional healers and their clients in rural Uganda: Results from a cross-sectional study
(International journal of STD & AIDS, 2021)Uptake of HIV testing is suboptimal in Uganda, particularly in rural communities. Reaching UNAIDS95-95-95 goals requires strategies to increase HIV testing among hard-to-reach populations. This cross-sectional study sought ... -
Early biting and insecticide resistance in the malaria vector Anopheles might compromise the effectiveness of vector control intervention in Southwestern Uganda
(Malaria journal, 2015)Background: Southwestern Uganda has high malaria heterogeneity despite moderate vector control and other interventions. Moreover, the early biting transmission and increased resistance to insecticides might compromise ... -
In‑vivo and in‑silico studies revealed the molecular mechanisms of Colocasia esculenta phenolics as novel chemotherapy against benign prostatic hyperplasia via inhibition of 5α‑reductase and α1‑adrenoceptor
(In Silico Pharmacology, 2023)Benign Prostatic Hyperplasia (BPH) is a major cause of lower urinary tract infections and erectile dysfunction thus a major contributor to lowering the quality of life among older men. In this study, we investigated the ... -
Diagnosing Severe Falciparum Malaria in Parasitaemic African Children- a Prospective Evaluation of Plasma Pf HRP2 Measurement
(PLOS Medicine, 2012)Background: In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidental Plasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein ... -
Carriage prevalence and serotype distribution of Streptococcus pneumoniae prior to 10-valent pneumococcal vaccine introduction- population-based cross-sectional study in South Western Uganda, 2014
(Vaccine, 2017)Background: Information on Streptococcus pneumoniae nasopharyngeal (NP) carriage before the pneumococcal conjugate vaccine (PCV) introduction is essential to monitor impact. The 10-valent PCV (PCV10) was officially introduced ... -
Predictors of delayed culture conversion among Ugandan patients
(BMC infectious diseases, 2017)Background: Estimates of month-2 culture conversion, a proxy indicator of tuberculosis (TB) treatment efficacy in phase-2 trials can vary by culture-type and geographically with lower rates reported among African sites. ... -
Prospective cohort study of the feasibility and yield of household child tuberculosis contact screening in Uganda
(The International Journal of Tuberculosis and Lung Disease, 2017)Setting: Screening and isoniazid preventive therapy (IPT) of child contacts of tuberculosis (TB) patients is poorly implemented in resource-limited countries, in part due to difficulties in TB diagnosis in children. ... -
Inhaled Nitric Oxide and Cerebral Malaria: Basis of a Strategy for Buying Time for Pharmacotherapy
(The Pediatric Infectious Disease Journal, 2012)There are approximately 225–600 million new malaria infections worldwide annually, with severe and cerebral malaria representing major causes of death internationally. The role of nitric oxide (NO) in the host response in ... -
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
(The Lancet, 2010)Background: Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from ... -
Male Gender is independently associated with pulmonary tuberculosis among sputum and non-sputum producers people with presumptive tuberculosis in Southwestern Uganda
(BMC infectious diseases, 2014)Background: Little is known about the association between gender and risk of TB infection. We sought to assess the impact of gender on TB prevalence among people with presumptive tuberculosis at a regional referral hospital ... -
“Everything is a Mess”: How COVID‑19 is Impacting Engagement with HIV Testing Services in Rural Southwestern Uganda
(AIDS and Behavior, 2020)In southwestern Uganda, where HIV prevalence among sexually active adults is ~ 7% [1], we have been conducting longitudinal research to improve uptake of HIV testing among communities who utilize informal health providers, ... -
Diagnostic Accuracy of the Small Membrane Filtration Method for Diagnosis of Pulmonary Tuberculosis in a High-HIV-Prevalence Setting
(Journal of clinical microbiology, 2016)Sputumacid-fastbacilli (AFB) smear microscopy has suboptimal sensitivity but remains the most commonly used laboratory test to diagnose pulmonary tuberculosis (TB). We prospectively evaluated the small membrane filtration ... -
Conceptual model for pluralistic healthcare behaviour: results from a qualitative study in southwestern Uganda
(BMJ open, 2020)Introduction: Medical pluralism, or concurrent utilisation of multiple therapeutic modalities, is common in various international contexts, and has been characterised as a factor contributing to poor health outcomes in ... -
Characteristics of human encounters and social mixing patterns relevant to infectious diseases spread by close contact: a survey in Southwest Ugand
(BMC infectious diseases, 2018)Background: Quantification of human interactions relevant to infectious disease transmission through social contact is central to predict disease dynamics, yet data from low-resource settings remain scarce. Methods: We ... -
Spectral properties of sub-kilometer-scale equatorial irregularities as seen by the Swarm satellites
(Advances in Space Research, 2023)Abstract The faceplates on-board the Swarm satellites have provided high-resolution measurements of electron density at a frequency of 16 Hz along the satellite paths. The 16-Hz electron density data from Swarm were ... -
Prognostic algorithms for post-discharge readmission and mortality among mother-infant dyads- an observational study protocol
(Frontiers in Epidemiology, 2023)Introduction: In low-income country settings, the first six weeks after birth remain a critical period of vulnerability for both mother and newborn. Despite recommendations for routine follow-up after delivery and facility ... -
Sudan virus disease super-spreading, Uganda, 2022
(BMC Infectious Diseases, 2024)Background: On 20 September 2022, Uganda declared its fifth Sudan virus disease (SVD) outbreak, culminating in 142 confirmed and 22 probable cases. The reproductive rate (R) of this outbreak was 1.25. We described persons ... -
Distribution and antifungal susceptibility profile of oropharyngeal Candida species isolated from people living with HIV in the era of universal test and treat policy in Uganda
(Therapeutic Advances in Infectious Disease, 2024)Background: Despite the increased frequency of oropharyngeal candidiasis among people living with human immunodeficiency virus (HIV), its management is no longer effective due to empirical treatment and emergence of ... -
How Does Antiretroviral Treatment Attenuate the Stigma of HIV? Evidence from a Cohort Study in Rural Uganda
(AIDS and Behavior, 2013)Program implementers and qualitative researchers have described how increasing availability of HIV antiretroviral therapy (ART) is associated with improvements in psychosocial health and internalized stigma. To determine ... -
Safety profile of colocasia esculenta tuber extracts in benign prostate hyperplasia
(BMC complementary medicine and therapies, 2023)Introduction: This study was motivated by the increasing global incidence of benign prostatic hyperplasia (BPH) and the promising potential of nutraceuticals as complementary therapies in ameliorating its burden. We report ...