Browsing Department of Pharmacy by Author "Aber, Jacqueline"
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ADMET profiling and molecular docking of potential antimicrobial peptides previously isolated from African catfish, Clarias gariepinus
Okella, Hedmon; Okello, Emmanuel; Mtewa, Andrew Glory; Ikiriza, Hilda; Kaggwa, Bruhan; Aber, Jacqueline; Ndekezi, Christian; Nkamwesiga, Joseph; Ajayi, Clement Olusoji; Mugeni, Ivan Mulongo; Ssentamu, Geofrey; Ochwo, Sylvester; Odongo, Steven; Tolo, Casim Umba; Kato, Charles Drago; Engeu, Patrick Ogwang (Frontiers in Molecular Biosciences, 2022)Amidst rising cases of antimicrobial resistance, antimicrobial peptides (AMPs) are regarded as a promising alternative to traditional antibiotics. Even so, poor pharmacokinetic profiles of certain AMPs impede their utility ... -
Bacterial Cell Envelope Lysis and Hemotoxicity of Peptides Previously isolated From African Catfish, Clarias gariepinus
Okella, Hedmon; Ajayi, Clement Olusoji; Ikiriza, Hilda; Mtewa, Andrew Glory; Kaggwa, Bruhan; Aber, Jacqueline; Kato, Charles Drago; Ogwang, Patrick Engeu (East African Science, 2022-06)Background: The skin mucus layer of fish is endowed with biologics including, Antimicrobial peptides (AMPs) that offer a first line of defence against pathogens. Such peptides can either inhibit bacterial growth or completely ... -
Identification of Antimicrobial Peptides Isolated From the Skin Mucus of African Catfish, Clarias gariepinus (Burchell, 1822)
Okella, Hedmon; Ikiriza, Hilda; Ochwo, Sylvester; Ajayi, Clement Olusoji; Ndekezi, Christian; Nkamwesiga, Joseph; Kaggwa, Bruhan; Aber, Jacqueline; Mtewa, Andrew Glory; Koffi, Tindo Kevin; Odongo, Steven; Vertommen, Didier; Kato, Charles Drago; Ogwang, Patrick Engeu (Frontiers in microbiology, 2021)Antimicrobial peptides (AMPs) constitute a broad range of bioactive compounds in diverse organisms, including fish. They are effector molecules for the innate immune response, against pathogens, tissue damage and infections. ... -
In vitro anti-tuberculous study on the combination of extracts of stem-bark of Erythrina abyssinica Lam. ex DC and conventional drugs
Aber, Jacqueline; Ogwang, Patrick Engeu; Anyama, Norbert; Ajayi, Clement Olusoji (Journal of Pharmacognosy and Phytochemistry, 2019)Background: Tuberculosis (TB) caused by Mycobacterium tuberculosis remains an important public health issue worldwide and TB patients are reported to use conventional drugs concurrently with medicinal plants. This study ... -
New Putative Antimicrobial Candidates: In silico Design of Fish-Derived Antibacterial Peptide-Motifs
Okella, Hedmon; Georrge, John J.; Ochwo, Sylvester; Ndekezi, Christian; Koffi, Kevin Tindo; Aber, Jacqueline; Ajayi, Clement Olusoji; Fofana, Fatoumata Gnine; Ikiriza, Hilda; Mtewa, Andrew G.; Nkamwesiga, Joseph; Bassogog, Christian Bernard Bakwo; Kato, Charles Drago; Ogwang, Patrick Engeu (Frontiers in Bioengineering and Biotechnology, 2020)Antimicrobial resistance remains a great threat to global health. In response to the World Health Organizations’ global call for action, nature has been explored for novel and safe antimicrobial candidates. To date, fish ... -
Safety and Efficacy of Medicinal Plants Used to Manufacture Herbal Products with Regulatory Approval in Uganda: A Cross-Sectional Study
Kaggwa, Bruhan; Kyeyune, Henry; Munanura, Edson Ireeta; Anywar, Godwin; Lutoti, Stephen; Aber, Jacqueline; Bagoloire, Lynn K.; Weisheit, Anke; Tolo, Casim Umba; Kamba, Pakoyo Fadhiru; Ogwang, Patrick Engeu (Evidence-Based Complementary and Alternative Medicine, 2022)Introduction: Uganda National Drug Authority requires phytochemical screening, freedom from microbial contamination, and evidence of safety and efficacy of the constituent plants to register herbal products. Since Uganda ...