Browsing Department of Pharmacy by Issue Date
Now showing items 1-20 of 197
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Differential Effects of Chronic Ethanol Administration and Withdrawal on -Aminobutyric Acid Type A and NMDA Receptor Subunit Proteins in Male and Female Rat Brain
(2004-06)Background: Investigations have shown that chronic ethanol exposure results in selective alterations in levels of -aminobutyric acid (GABA)A and NMDA receptor subunits. We previously reported significant sex differences ... -
Impact of Sex: Determination of Alcohol Neuroadaptation and Reinforcement
(ALCHOLISM,Clinical and experimental Research, 2006-01-25)his article represents the proceedings of a symposium at the Research Society on Alcoholism meeting in Santa Barbara, California. The organizers/chairs were Kristine M. Wiren and Deborah A. Finn. Following a brief introduction ... -
Influence of hormonal status on behavioral responses to an acute ethanol challenge during ethanol withdrawal in male and female rats
(Pharmacology, Biochemistry and Behavior, 2008)We previously reported significant sex differences in ethanol withdrawal (EW) recovery as well as in sensitivity to GABAA receptor modulators during EW. The aim of the present study was to determine if hormonal status ... -
Ethno medical knowledge and traditional use of Aristolochia bracteolata Lam. for malaria among local communities in Jubek State of South Sudan: A cross-sectional survey
(Journal of Ethnopharmacology, 2009)Ethnopharmacological relevance: The recognized challenges to access conventional antimalarial medicines could have contributed to the extensive use of Aristolochia bracteolata Lam. (Aristolochiaceae) to manage malaria in ... -
Sustainable Diets and Biodiversity
(bioversity international, 2010-11-03)ct It is time to face the evidence of a worldwide unsustainable food system. Its complexity makes it extremely fragile to any climatic, socio-economic, political or financial crisis. Thus, we urgently need appropriate ... -
Pharmacognostic, antiplasmodial and antipyretic evaluation of the aqueous extract of Vernonia amygdalina leaf
(Int. J. Biol. Chem. Sci., 2011)The impeding safety challenges to the use of herbs have made qualitative and quantitative evaluation of herbal preparations a necessity. This study was aimed at evaluating the pharmacognostic and pharmacological properties ... -
Potential drug-drug interactions on in-patient medication prescriptions at Mbarara Regional Referral Hospital (MRRH) in western Uganda: prevalence, clinical importance and associated factors
(African Health Sciences, 2011)Background: Drug-drug interactions (DDIs) are an important cause of adverse drug reactions. The pharmacoepidemiology of such interactions in hospitals in Uganda is not known. Objectives: To determine the prevalence, ... -
Infections
(African Health Sciences, 2011-09)Background: Medicinal plants in Uganda and other developing countries have been scientifically demonstrated to have medicinal benefits but few or none have been translated to products for clinical use. Most herbal products ... -
Acute toxicity, antipyretic and antinociceptive study of the crude saponin from an edible vegetable
(Int. J. Biol. Chem. Sci., 2012)Vernonia amygdalina is commonly used for food and health purposes. Processing of the leaf for food is aimed at removing bitter tasting antinutritional principles like saponins. This study was designed to determine the ... -
SUSTAINABLE DIETS AND BIODIVERSITY
(SUSTAINABLE DIETS AND BIODIVERSITY DIRECTIONS AND SOLUTIONS FOR POLICY, RESEARC, 2012)It is time to face the evidence of a worldwide unsustainable food system. Its complexity makes it extremely fragile to any climatic, socio-economic, political or financial crisis. Thus, we urgently need appropriate ... -
Concomitant herbal medicine and Antiretroviral Therapy (ART) use among HIV patients in Western Uganda: A cross-sectional analysis of magnitude and patterns of use, associated factors and impact on ART adherence
(AIDS Care, 2012)Use of herbal medicines among patients receiving Anti-Retroviral Therapy (ART) remains by far an un characterised phenomenon in Africa and Uganda specifically. We evaluated the use of herbal medicines among patients on ART ... -
Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial
(Malaria journal, 2012-05)Background: Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, randomized controlled trial in Mbarara, Uganda ... -
Aflatoxins metabolism, effects on epigenetic mechanisms and their role in carcinogenesis
(SciRes, 2013)Chronic consumption of aflatoxin-contaminated foods is a global problem in both developing and developed countries especially where there is poor regulation of their levels in foods. In the body, aflatoxins (AFBs) mainly ... -
Antipyretic and Antinociceptive Properties of the Aqueous Extract and Saponin from an Edible Vegetable- Vernonia Amygdalina Leaf
(African Journal of food, agriculture, nutrition and development, 2013)Vernonia amygdalina is commonly used for food and health purposes. The processing of the leaf for food is usually aimed at removing bitter tasting principles like saponins. This study was designed to determine the antipyretic ... -
Registration, procurement, distribution, and use of misoprostol in Uganda: an interview-based observational study
(The Lancet, 2013-10-20)Background: Poor access to essential medicines remains a barrier to improvement of health in low-income countries. The maternal mortality rate from post-partum haemorrhage (PPH) in Uganda is one of the highest in the world. ... -
Whole Plant Approaches to Therapeutic Use of Artemisia annua L. (Asteraceae)
(rtemisia annua - Pharmacology and Biotechnology, 2013-11-27)Long used as a therapeutic tea by the Chinese to treat fever, Artemisia annua is more recently being studied and used for eventual treatment for not only malaria, but also many other diseases. This chapter describes studies ... -
Sublingual Misoprostol versus Intramuscular Oxytocin for Prevention of Postpartum Hemorrhage in Uganda
(PLoS Med, 2014)Background: Postpartum hemorrhage (PPH) is a leading cause of maternal death in sub-Saharan Africa. Although the World Health Organization recommends use of oxytocin for prevention of PPH, misoprostol use is increasingly ... -
Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?
(World journal of pharmacology,, 2014)Artemisinin from the plant Artemisia annua (A. annua) L., and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in ... -
Effects of aqueous root bark extract of Citropsis articulata (Swingle & Kellerman) on sexual function in male rats
(Academic Journals, 2014-11-11)About 80% of the world’s population uses herbal medicine for the treatment of various health conditions. Erectile dysfunction is one of the conditions commonly treated using traditional herbs on large scale. In this ... -
Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?
(World journal of pharmacology, 2014-12)Artemisinin from the plant Artemisia annua (A. annua) L, and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in ...
