Department of Internal Medicine: Recent submissions
Now showing items 101-120 of 258
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Association of Hyponatremia on Mortality in Cryptococcal Meningitis: A Prospective Cohort
(Open Forum Infectious Diseases, 2022-06-17)Background: Sodium abnormalities are frequent in central nervous system infections and may be caused by cerebral salt wasting, syndrome of inappropriate antidiuretic hormone secretion, or medication adverse events. In ... -
Sterile Cerebrospinal Fluid Culture at Cryptococcal Meningitis Diagnosis Is Associated with High Mortality
(Journal of Fungi, 2023)Cryptococcus is the leading cause of AIDS-related meningitis in sub-Saharan Africa. The clinical implications of a sterile cerebrospinal fluid (CSF) culture among individuals diagnosed with cryptococcal meningitis using ... -
Cigarette smoking is associated with an increase in blood monocytes in people with tuberculosis A cross-sectional study
(Medicine, 2022)The effect of smoking on immune responses in people with tuberculosis (TB) is not well elucidated. We aimed to compare peripheral blood counts of CD4+ and CD87 + T-lymphocytes, monocytes, and neutrophils and the CD4:CD8 ... -
Burden, clinical features and outcomes of post-tuberculosis lung disease in sub Saharan Africa: a protocol for a systematic review and meta-analysis
(BMJ open, 2022)Introduction: Tuberculosis (TB) is significantly associated with multiple post infectious, non-communicable diseases after microbiological cure. For example, those with a history of TB disease have a higher risk of developing ... -
Therapeutic lumbar punctures in HIV-associated cryptococcal meningitis: should opening 3 pressure direct management
(In Open Forum Infectious Diseases, 2022)Background: Increased intracranial pressure (ICP) frequently complicates cryptococcal meningitis. Therapeutic lumbar punctures (LPs) have acute survival benefits in the first week, 4and we sought to understand the longer-term ... -
Risk Factors of Esophageal Squamous Cell Cancer in Southwestern Uganda: A Case-Control Study
(Jacobs Journal of Internal Medicine, 2015)Background: Despite the high rates and regional variations of squamous cell cancer of the esophagus (ESCC) in East Africa, little is known about the region specific risk factors. We aim to determine factors associated with ... -
How Does Antiretroviral Treatment Attenuate the Stigma of HIV? Evidence from a Cohort Study in Rural Uganda
(AIDS and Behavior, 2013)Program implementers and qualitative researchers have described how increasing availability of HIV antiretroviral therapy (ART) is associated with improvements in psychosocial health and internalized stigma. To determine ... -
Validation of heart failure quality of life tool and usage to predict all-cause mortality in acute heart failure in Uganda: the Mbarara heart failure registry (MAHFER)
(BMC Cardiovascular Disorders, 2018)Background: The health-related quality of life (HRQoL) is an important treatment goal that could serve as low-cost prognostication tool in resource poor settings. We sought to validate the Kansas City Cardiomyopathy ... -
Stroke Mortality Outcomes in Uganda
(Journal of Stroke and Cerebrovascular Diseases, 2021)Background and Purpose: Stroke outcome data in Uganda is lacking. The objective of this study was to capture 30-day mortality outcomes in patients presenting with acute and subacute stroke to Mbarara Regional Referral ... -
HIV Infection Is an Independent Predictor of Mortality Among Adults with Reduced Level of Consciousness in Uganda
(The American journal of tropical medicine and hygiene, 2022)The clinical epidemiology of adults admitted with reduced level of consciousness (LOC) in sub-Saharan Africa (SSA) and the impact of HIV infection on the risk of mortality in this population is unknown. We secondarily ... -
Global Dialysis Perspective: Uganda
(Kidney 360, 2022)Kidney injury and CKD are common complications of infectious and non-communicable diseases (NCDs) alike. Patients with advanced kidney disease need RRT in the form of dialysis or renal transplantation. Both these interventions ... -
Epidemiology of HBV infection in a cohort of Ugandan HIV-infected patients and rate and pattern of lamivudine-resistant HBV infection in patients receiving antiretroviral therapy
(Transactions of The Royal Society of Tropical Medicine and Hygiene, 2015)Background: Many HIV-infected patients in sub-Saharan Africa are not routinely screened for hepatitis B virus (HBV) infection and are on antiretroviral therapy (ART) regimens containing only lamivudine as anti-HBV active ... -
Dietary patterns and practices in rural eastern Uganda: Implications for prevention and management of type 2 diabetes
(Appetite, 2019)Background: The burden of type 2 diabetes in Sub-Saharan Africa is projected to double by 2040, partly attributable to rapidly changing diets. In this paper, we analysed how community members in rural Uganda understood the ... -
Diagnostic and Treatment Challenges of Paroxysmal Nocturnal Hemoglobinuria in Uganda
(Case Reports in Hematology, 2019-01-13)Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disorder of the hematopoietic stem cells which is often underdiagnosed. Its incidence is about 5 cases per million inhabitants in a year, and currently, ... -
Outcomes of patients with severe infection in Uganda according to adherence to the World Health Organization's Integrated Management of Adolescent and Adult Illness fluid resuscitation guidelines
(Journal of Critical Care, 2017)Purpose: We determined outcomes in hospitalized patients in Uganda with World Health Organization's Integrated Management of Adolescent and Adult Illness (IMAI) defined septic shock (IMAI-shock) or severe respiratory ... -
Adherence to Antihypertensive Medication: An Interview Analysis of Southwest Ugandan Patients’ Perspectives
(Annals of Global Health, 2020)Background: Hypertension is a significant cardiovascular disease (CVD) and driver to CVD disorders in sub-Saharan Africa. It is a major independent risk factor for heart failure, stroke, and kidney failure. Per¬sons living ... -
Early empiric anti-Mycobacterium tuberculosis therapy for sepsis in sub-Saharan Africa: a protocol of a randomised clinical trial
(BMJ Open, 2022)Introduction: Sub-Saharan Africa shoulders the highest burden of global sepsis and associated mortality. In high HIV and tuberculosis (TB) prevalent settings such as sub-Saharan Africa, TB is the leading cause of sepsis. ... -
Super learner analysis of real-time electronically monitored adherence to antiretroviral therapy under constrained optimization and comparison to non-differentiated care approaches for persons living with HIV in rural Uganda
(Journal of the International AIDS Society, 2020)Introduction: Real-time electronic adherence monitoring (EAM) systems could inform on-going risk assessment for HIV viraemia and be used to personalize viral load testing schedules. We evaluated the potential of real-time ... -
Reversal of the Kynurenine Pathway of Tryptophan Catabolism May Improve Depression in ART-treated HIV-infected Ugandans
(Journal of acquired immune deficiency syndromes, 2014-04)Background: Major depressive disorder is highly prevalent among HIV-infected persons, and depression symptom severity improves during the course of HIV antiretroviral therapy (ART). The potential biologic pathways explaining ... -
Real-time electronic adherence monitoring plus follow-up improves adherence compared to standard electronic adherence monitoring
(AIDS, 2017-01)The impact of real-time electronic monitoring on antiretroviral therapy adherence warrants further study. We conducted an analysis of cohort participants that initially involved standard electronic adherence monitoring ...
