Department of Internal Medicine: Recent submissions
Now showing items 81-100 of 258
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Coinfection of COVID-19 and Tuberculosis in Uganda
(The American Journal of Tropical Medicine and Hygiene, 2023)The clinical features and outcomes of tuberculosis (TB) and COVID-19 coinfection are not well established. This short report describes 11 people with TB/COVID-19 coinfection in Uganda. The mean age was 46.9 6 14.5 years; ... -
“If you have light, your heart will be at peace”: A qualitative study of household lighting and social integration in southwestern Uganda
(Journal of Global Health, 2023)Background: Expanding electrification and access to other clean and affordable energy, such as solar energy, is a critical component of the Sustainable Development Goals, particularly in sub-Saharan Africa where 70% of ... -
Prevalence and grade of diabetic peripheral neuropathy among known diabetic patients in rural Uganda
(Frontiers in Clinical Diabetes and Healthcare, 2022)Background: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). Approximately 50% of diabetic patients are estimated to develop DPN, depending on disease duration and diabetic ... -
Impact of alcohol use disorder severity on human immunodeficiency virus (HIV) viral suppression and CD4 count in three international cohorts of people with HIV
(Clinical and Experimental Research, 2023)Background: Alcohol use has been linked to worse human immunodeficiency virus (HIV) immunologic/virologic outcomes, yet few studies have explored the effects of alcohol use disorder (AUD). This study assessed whether AUD ... -
Decision Analytic Modeling for Global Clinical Trial Planning: A Case for HIV-Positive Patients at High Risk for Mycobacterium tuberculosis Sepsis in Uganda
(International Journal of Environmental Research and Public Health, 2023)Sepsis is a significant cause of mortality among people living with human immunodeficiency virus (HIV) in sub-Saharan Africa. In the planning period prior to the start of a large multi-country clinical trial studying the ... -
Four Learner Categories in Global Health Experiences: A Framework for Successful Resident Engagement
(Annals of Global Health, 2022)An increasing number of residency programs in the United States now offer global health experiences for trainees, yet many participating residents lack the behaviors and skills needed to engage effectively with local ... -
Food insecurity, depression and the modifying role of social support among people living with HIV/AIDS in rural Uganda
(Social science & medicine, 2012)Depression is common among people living with HIV/AIDS and contributes to a wide range of worsened HIV-related outcomes, including AIDS-related mortality. Targeting modifiable causes of depression, either through primary ... -
Bedside measures of malnutrition and association with mortality in hospitalized adults
(Clinical nutrition, 2015)Background & aims: The impact of malnutrition on the outcomes of hospitalized adults in resource limited settings such as sub-Saharan Africa (SSA) is not fully described. We aimed to determine the association between ... -
Correction: Gender differences among patients with drug resistant tuberculosis and HIV co‑infection in Uganda: a countrywide retrospective cohort study
(BMC Infectious Diseases, 2023)Following publication of the original article [1], the authors identified an error in the author name of Anna M. Stadelman. Additionally, the ORCID number was previously unavailable. The incorrect author name is: Anna ... -
Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries
(The Lancet infectious diseases, 2019)In 2018, WHO issued guidelines for the diagnosis, prevention, and management of HIV-related cryptococcal disease. Two strategies are recommended to reduce the high mortality associated with HIV-related cryptococcal meningitis ... -
How Does Antiretroviral Treatment Attenuate the Stigma of HIV? Evidence from a Cohort Study in Rural Uganda
(AIDS and Behavior, 2013)Program implementers and qualitative researchers have described how increasing availability of HIV antiretroviral therapy (ART) is associated with improvements in psychosocial health and internalized stigma. To determine ... -
High Mobility Group Box 1 (HMGB1) and HIV-Associated Kaposi’s Sarcoma in Africa
(Academia.edu, 2015)Other than Kaposi’s sarcoma-associated herpesvirus (KSHV) and CD4+ T cell lymphopenia, the mechanisms responsible for KS are poorly understood. Additional mechanisms must exist in sub-Saharan Africa given that only a ... -
Causal impact of malnutrition on mortality among adults hospitalized for medical illness in sub-Saharan Africa: what is the role of severe sepsis?
(BMC Nutrition, 2015)Background: In sub-Saharan Africa, malnutrition is associated with mortality in adults hospitalized for medical illness. However, it remains unclear whether this association is causal, and if causal, what the potential ... -
HIV-Associated Cryptococcal Meningitis Occurring at Relatively Higher CD4 Counts
(The Journal of infectious diseases, 2019)Background: Cryptococcal meningitis can occur in persons with less-apparent immunosuppression. We evaluated clinical characteristics and outcomes of persons with HIV-related Cryptococcus presenting with higher CD4 ... -
Perceived barriers and facilitators to antiretroviral therapy adherence among youth aged 15-24 years at a regional HIV clinic in SouthWestern Uganda: a qualitative study
(African Health Sciences, 2022)Introduction: South-Western region has the second highest HIV prevalence in Uganda. Youth aged 15-24 have shown poor adherence to antiretroviral therapy compared to the older cohorts. Previous studies from other regions ... -
Diagnostic and Prognostic Value of Cerebrospinal Fluid Lactate and Glucose in HIV-Associated Tuberculosis Meningitis
(Microbiology Spectrum, 2022)The role of cerebrospinal fluid (CSF) lactate in tuberculosis meningitis (TBM) diagnosis and prognosis is unclear. The aim of this study was to evaluate the performance of CSF lactate alone and in combination with CSF ... -
Intensified tuberculosis treatment to reduce the mortality of HIV‑infected and uninfected patients with tuberculosis meningitis (INTENSE‑TBM): study protocol for a phase III randomized controlled trial
(2022)Background: Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in ... -
Capacity Building in Sub-Saharan Africa as Part of the INTENSE-TBM Project During the COVID-19 Pandemic
(Infectious Diseases and Therapy, 2022)Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), with at least 100,000 cases per year and a mortality rate of up to 50% in individuals co-infected with human immunodeficiency virus ... -
Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-Saharan Africa: an economic analysis of the AMBITION-cm trial
(The Lancet Global Health, 2022)Background HIV-associated cryptococcal meningitis is a leading cause of AIDS-related mortality. The AMBITION-cm trial showed that a regimen based on a single high dose of liposomal amphotericin B deoxycholate (AmBisome ... -
A secondary analysis of depression outcomes from a randomized controlled trial of adjunctive sertraline for HIV associated cryptococcal meningitis
(Wellcome Open Research, 2022)Background: Depression is a risk factor for worse HIV outcomes in persons living with HIV/AIDS, including engagement-in-care, HIV medication adherence, and retention-in-care. Depression has a prevalence of more than three ...
