Department of Internal Medicine: Recent submissions

Now showing items 141-160 of 258

    • Internalized stigma, depressive symptoms, and the modifying role of antiretroviral therapy: A cohort study in rural Uganda 

      Bebella, Lisa M.; Kembabazi, Annet; Musinguzi, Nicholas; Martin, Jeffrey N.; Hunt, Peter W.; II, Yap Boum; O’Laughlini, Kelli N.; Muzoora, Conrad; Haberer, Jessica E.; Bwana, Mwebesa Bosco; Bangsberg, David R.; Siedner, Mark J.; Tsai, Alexander C. (SSM-Mental Health, 2021)
      Depression affects over 40% of people with HIV (PHIV) in low- and middle-income countries, and over half of PHIV report HIV-related internalized stigma. However, few longitudinal studies of PHIV have examined the relationship ...

    • High dose oral and intravenous rifampicin for improved survival from adult tuberculous meningitis: a phase II open-label randomised controlled trial (the RifT study) [version 1; referees: 2 approved] 

      Cresswell, Fiona V.; Ssebambulidde, Kenneth; Grint, Daniel; Brake, Lindsey te; Musabire, Abdul; Atherton, Rachel R.; Tugume, Lillian; Muzoora, Conrad; Lukande, Robert; Lamorde, Mohammed; Aarnoutse, Rob; Meya, David; Boulware, David R.; Elliott, Alison M. (Wellcome open researc, 2018)
      Background: Tuberculous meningitis (TBM) has 44% (95%CI 35-52%) in-hospital mortality with standard therapy in Uganda. Rifampicin, the cornerstone of TB therapy, has 70% oral bioavailability and ~10-20% cerebrospinal fluid ...

    • Handheld Point-of-Care Cerebrospinal Fluid Lactate Testing Predicts Bacterial Meningitis in Uganda 

      Majwala, Albert; Burke, Rebecca; Patterson, William; Pinkerton, Relana; Muzoora, Conrad; Wilson, L. Anthony; Moore, Christopher C. (The American Journal of Tropical Medicine and Hygiene, 2013)
      We validated a handheld point-of-care lactate (POCL) monitor’s ability to measure lactate in cerebrospinal fluid (CSF) and diagnose bacterial meningitis in Uganda. There was a strong linear correspondence between POCL and ...

    • Genotypic and Mechanistic Characterization of Subtype- Specific HIV Adaptation to Host Cellular Immunity 

      Kinloch, Natalie N.; Lee, Guinevere Q.; Carlson, Jonathan M.; Jin, Steven W.; Brumme, Chanson J.; Byakwaga, Helen; Muzoora, Conrad; Bwana, Mwebesa B.; Cobarrubias, Kyle D.; Hunt, Peter W.; Martin, Jeff N.; Carrington, Mary; Bangsberg, David R.; Harrigan, P. Richard; Brockman, Mark A.; Brumme, Zabrina L (Journal of virology, 2018)
      The extent to which viral genetic context influences HIV adaptation to human leukocyte antigen (HLA) class I-restricted immune pressures remains incompletely understood. The Ugandan HIV epidemic, where major pandemic group ...

    • Evidence for the Reliability and Validity of the Internalized AIDSRelated Stigma Scale in Rural Uganda 

      Tsai, Alexander C.; Weiser, Sheri D.; Steward, Wayne T.; Mukiibi, Nozmo F.B.; Kawuma, Annet; Kembabazi, Annet; Muzoora, Conrad; Hunt, Peter W.; Martin, Jeffrey N.; Bangsberg, David R. (AIDS and Behavior, 2013)
      HIV infection remains highly stigmatized throughout sub-Saharan Africa despite the increasing availability of treatment. HIV-related stigma is commonly described to be highly prevalent in East Africa, but none of these ...

    • CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in Uganda: Pooled Analysis of Two Prospective Studies 

      Chang, Jonathan L.; Lee, Sulggi A.; Tsai, Alexander C.; Musinguzi, Nicholas; Muzoora, Conrad; Bwana, Bosco; II, Yap Boum; Haberer, Jessica E.; Hunt, Peter W.; Martin, Jeff; Bangsberg, David R.; Kroetz, Deanna L.; Siedner, Mark J. (AIDS research and human retroviruses, 2018)
      Single-nucleotide polymorphisms (SNPs) in CYP2B6 have been shown to predict variation in plasma efavirenz concentrations, but associations between these SNPs and efavirenz-mediated depression and viral suppression are less ...

    • Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis 

      Okafor, Elizabeth C.; Hullsiek, Katherine H; Williams, Darlisha A.; Scriven, James E.; Rhein, Joshua; Nabeta, Henry W.; Musubire, Abdu K.; Rajasingham, Radha; Muzoora, Conrad; Schutz, Charlotte; Meintjes, Graeme; Meya, David B.; Boulware, David R. (Mediators of Inflammation, 2020-10-29)
      Background: Though peripheral blood is a crucial sample to study immunology, it is unclear whether the immune environment in the peripheral vasculature correlates with that at the end-organ site of infection. Using ...

    • Association Between Immunoglobulin E Levels and Kaposi Sarcoma in African Adults With Human Immunodeficiency Virus Infection 

      Byakwaga, Helen; Guerrero, Arturo Barbachano; Wang, Dongliang; McAllister, Shane; Naphri, Kamal; Oketta, Miriam Laker; Muzoora, Conrad; Hunt, Peter W.; Martin, Jeffrey; King, Christine A. (The Journal of Infectious Diseases, 2021)
      It has been demonstrated that activated mast cells (MCs) are enriched in Kaposi sarcoma (KS) tumors and contribute to the inflammatory microenvironment. Mechanisms driving MC activation, however, are incompletely understood. ...

    • Antiretroviral Therapy Adherence Interruptions are Associated with Systemic Inflammation among Ugandans who Achieved Viral Suppression 

      Musinguzi, Nicholas; Jose, Castillo-Mancilla; Morrow, Mary; Byakwaga, Helen; Mawhinney, Samantha; Burdo, Tricia H.; Boum, Yap; Muzoora, Conrad; Bwana, Bosco M.; Siedner, Mark J.; Martin, Jeffrey N.; Hunt, Peter W.; Bangsberg, David R.; Haberer, Jessica E. (Journal of acquired immune deficiency syndromes, 2019)
      Background: Residual systemic inflammation, which is associated with non-AIDS clinical outcomes, may persist despite viral suppression. We assessed the effect of antiretroviral (ART) adherence interruptions on systemic ...

    • Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes 

      Mann, Jaclyn K; Byakwaga, Helen; Kuang, Xiaomei T; Le, Anh Q; Brumme, Chanson J; Mwimanzi, Philip; Omarjee, Saleha; Martin, Eric; Lee, Guinevere Q; Baraki, Bemuluyigza; Danroth, Ryan; McCloskey, Rosemary; Muzoora, Conrad; Bangsberg, David R; Hunt, Peter W; Goulder, Philip JR; Walker, Bruce D; Harrigan, P Richard; Martin, Jeff N; Ndung’u, Thumbi; Brockman, Mark A; Brumme, Zabrina L (Retrovirology, 2013)
      Background: The highly genetically diverse HIV-1 group M subtypes may differ in their biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a comprehensive inter-subtype comparison ...

    • A pragmatic approach to managing antiretroviral therapy-experienced patients diagnosed with HIVassociated cryptococcal meningitis: impact of antiretroviral therapy adherence and duration 

      Alufandika, Melanie; Lawrence, David S.; Chammard, Timoth ee Boyer; Kanyama, Cecilia; Ndhlovu, Chiratidzo E.; Mosepele, Mosepele; Tugume, Lillian; Meya, David; Boulware, David R.; Rhein, Joshua; Muzoora, Conrad; Youssouf, Nabila; Molloy, Sı´le F.; Schutz, Charlotte; Lortholary, Olivier; Meintjes, Graeme; Mwandumba, Henry C.; Harrison, Thomas S.; Jarvis, Joseph N.; AMBITION-cm Study Group (AIDS, 2020)
      Cryptococcal meningitis accounts for 15% of all HIV related deaths [1]. The overall number of cryptococcal meningitis cases has remained relatively stable in many low-to-middle income countries (LMICs) despite increasing ...

    • A Journey of Hope: giving research participants a voice to share their experiences and improve community engagement around advanced HIV disease in Uganda [version 2; peer review: 2 approved] 

      Cresswell, Fiona V.; Kasibante, John; Martyn, Emily M.; Tugume, Lillian; Stead, Gavin; Ssembambulidde, Kenneth; Rutakingirwa, Morris K.; Kagimu, Enock; Nsangi, Laura; Namuju, Carol; Ndyetukira, Jane F.; Ahimbisibwe, Cynthia; Kugonza, Florence; Sadiq, Alisat; Namudde, Alice; Dobbin, Joanna; Srishyla, Diksha; Quinn, Carson; Kabahubya, Mable; Muzoora, Conrad; Watiti, Stephen; Meya, David B.; Elliott, Alison M. (AAS open research, 2020)
      Over the last decade excellent progress has been made globally in HIV management thanks to antiretroviral therapy (ART) rollout and international guidelines now recommending immediate initiation of ART in people living ...

    • Evaluation of a point-of-care immunoassay test kit `StrongStep' for cryptococcal antigen detection 

      Mpoza, Edward; Mukaremera, Liliane; Kundura, Didas Atwebembere; Akampurira, Andrew; Luggya, Tonny; Tadeo, Kiiza Kandole; Pastick, Katelyn A.; Bridge, Sarah C.; Tugume, Lillian; Kiggundu, Reuben; Musubire, Abdu K.; Williams, Darlisha A.; Muzoora, Conrad; Nalintya, Elizabeth; Rajasingham, Radha; Rhein, Joshua; Boulware, David R.; Meya, David B.; Abassi, Mahsa (PLoS One, 2018)
      Background: HIV-associated cryptococcal meningitis is the leading cause of adult meningitis in Sub- Saharan Africa, accounting for 15%±20% of AIDS-attributable mortality. The development of point-of-care assays has greatly ...

    • Dissemination of Research Findings to Research Participants Living with HIV in Rural Uganda: Challenges and Rewards 

      Baylor, Anna; Muzoora, Conrad; Bwana, Mwebsa; Kembabazi, Annet; Haberer, Jessica E.; Matthews, Lynn T.; Tsai, Alexander C.; Hunt, Peter W.; Martin, Jeffrey N.; Bangsberg, David R. (PLOS Medicine, 2013-03-05)
      Community participatory research emphasizes communication of study findings to research participants of vulnerable populations [1]. Most dissemination activities in sub-Saharan Africa have occurred after the completion (or ...

    • Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes 

      Umviligihozo, Gisele; Cobarrubias, Kyle D.; Chandrarathna, Sandali; Jin, Steven W.; Reddy, Nicole; Byakwaga, Helen; Muzoora, Conrad; Bwana, Mwebesa B.; Lee, Guinevere Q.; Hunt, Peter W.; Martin, Jeff N.; Brumme, Chanson J.; Bangsberg, David R.; Karita, Etienne; Allen, Susan; Hunter, Eric; Ndung’u, Thumbi; Brumme, Zabrina L.; Brockman, Mark A. (Journal of virology, 2020)
      Downregulation of BST-2/tetherin and CD4 by HIV-1 viral protein U (Vpu) promotes viral egress and allows infected cells to evade host immunity. Little is known however about the natural variability in these Vpu functions ...

    • Toxicity of Amphotericin B Deoxycholate-Based Induction Therapy in Patients with HIV-Associated Cryptococcal Meningitis 

      Bicanic, Tihana; Bottomley, Christian; Loyse, Angela; Brouwer, Annemarie E.; Muzoora, Conrad; Taseera, Kabanda; Jackson, Arthur; Phulusa, Jacob; Hosseinipour, Mina C.; Horst, Charles van der; Limmathurotsakul, Direk; White, Nicholas J.; Wilson, Douglas; Wood, Robin; Meintjes, Graeme; Harrison, Thomas S.; Jarvisl, Joseph N. (Antimicrobial agents and chemotherapy, 2015)
      Amphotericin B deoxycholate (AmBd) is the recommended induction treatment for HIV-associated cryptococcal meningitis (CM). Its use is hampered by toxicities that include electrolyte abnormalities, nephrotoxicity, and anemia. ...

    • Effects of the Oral Administration of Aqueous and Methanolic Leaf Extracts of Chenopodium ambrosioides L. (Amaranthaceae) on Blood Glucose Levels in Wistar Rats 

      Kasali, Félicien Mushagalusa; Kadima, Justin Ntokamunda; Tusiimire, Jonans; Ajayi, Clement Olusoji; Agaba, Amon Ganafa (Journal of Experimental Pharmacology, 2022-04-26)
      Background: Diabetes mellitus is a metabolic disorder that poses a major global health threat. The current diabetes mellitus uses insulin and oral hypoglycemic agents, which have limitations, including adverse effects and ...

    • Effect of a solar lighting intervention on fuel-based lighting use and exposure to household air pollution in rural Uganda: A randomized controlled trial 

      Wallach, Eli S.; Lam, Nicholas L.; Nuwagira, Edwin; Muyanja, Daniel; Tayebwa, Mellon; Valeri, Linda; Tsai, Alexander C.; Vallarino, Jose; Allen, Joseph G.; Lai, Peggy S. (Indoor Air, 2022)
      Solar lighting is an alternative to polluting kerosene and other fuel-based lighting devices relied upon by millions of families in resource-limited settings. Whether solar lighting provides sustained displacement of ...

    • Erratum to: The Changing Epidemiology of HIVAssociated Adult Meningitis, Uganda 2015–2017 

      Ellis, Jayne; Bangdiwala, Ananta S.; Cresswell, Fiona V.; Rhein, Joshua; Nuwagira, Edwin; Ssebambulidde, Kenneth; Tugume, Lillian; Rajasingham, Radha; Bridge, Sarah C.; Muzoora, Conrad; Meya, David B.; Boulware, David R. (Open Forum Infectious Diseases, 2019)
      An error appeared in an article published in the September 2019 issue: The Changing Epidemiology of HIV-Associated Adult Meningitis, Uganda 2015–2017. Open Forum Infect Dis. 2019 Sep 29;6(10):ofz419. doi: 10.1093/ofid/ofz419. ...

    • Tuberculous meningitis diagnosis and outcomes during the Xpert MTB/Rif era: a 6.5-year cohort study in Uganda 

      Cresswell, Fiona V.; Bangdiwala, Ananta S.; Bahr, Nathan C.; Trautner, Emily; Nuwagira, Edwin; Ellis, Jayne; Rajasingham, Radha; Rhein, Joshua; Williams, Darlisha A.; Muzoora, Conrad; Elliott, Alison M.; Meya, David B.; Boulware, David R. (Wellcome Open Research, 2018)
      Background: Tuberculous meningitis (TBM), a leading cause of meningitis in sub-Saharan Africa, is notoriously difficult to diagnose. In our Ugandan setting TB diagnostics have evolved rapidly in recent years, with introduction ...