Browsing Research Articles by Issue Date
Now showing items 1-20 of 256
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Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children
(Malaria journal, 2008-08)Results: Data analysed represented 2926 patients from 17 studies in nine African countries. Three ACTs were studied: artesunate-amodiaquine (AS+AQ, N = 1702), artesunate-sulphadoxinepyrimethamine (AS+SP, N = 706) and ... -
Independent Association between Rate of Clearance of Infection and Clinical Outcome of HIV-Associated Cryptococcal Meningitis: Analysis of a Combined Cohort of 262 Patients
(Clinical infectious diseases,, 2009)Background: Progress in therapy for cryptococcal meningitis has been slow because of the lack of a suitable marker of treatment response. Previously, we demonstrated the statistical power of a novel endpoint, the rate of ... -
Rate of clearance of infection is independently associated with clinical outcome in HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients
(Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, 2009)Background—Progress in therapy of cryptococcal meningitis has been slow because of the lack of a suitable marker of treatment response. Previously, we demonstrated the statistical power of a novel endpoint, the rate of ... -
Late disease stage at presentation to an HIV clinic in the era of free antiretroviral therapy in sub-Saharan Africa
(JAIDS Journal of Acquired Immune Deficiency Syndromes, 2009)Background: Access to free antiretroviral therapy (ART) in sub-Saharan Africa has been steadily increasing, and the success of large-scale ART programs depends on early initiation of HIV care. However, little is known about ... -
Antiretroviral Therapy is Associated with Increased Fertility Desire, but not Pregnancy or Live Birth, among HIV+ Women in an Early HIV Treatment Program in Rural Uganda
(AIDS and Behavior, 2009)To assess the association between antiretroviral therapy (ART) and fertility history and desire among HIV positive Ugandan women, we conducted a cross-sectional study among HIV-positive Ugandan women aged 18– 50 years who ... -
Highly Active Antiretroviral Therapy and Increased Use of Contraceptives Among HIV-Positive Women During Expanding Access to Antiretroviral Therapy in Mbarara, Uganda
(Andia, I., Kaida, A., Maier, M., Guzman, D., Emenyonu, N., Pepper, L., ... & Hogg, R. S. (2009). Highly active antiretroviral therapy and increased use of contraceptives among HIV-positive women during expanding access to antiretroviral therapy in Mbarara, Uganda. American journal of public health, 99(2), 340-347., 2009)Objectives: We investigatedwhether the prevalence of contraceptive use among women who are HIV positive varied according to use of highly active antiretroviral therapy (HAART) in Mbarara, Uganda. Methods: We used data ... -
Retention in Care among HIV-Infected Patients in Resource-Limited Settings: Emerging Insights and New Directions
(Current Hiv/aids Reports, 2010)In resource-limited settings—where a massive scale up of HIV services has occurred in the last 5 years— both understanding the extent of and improving retention in care presents special challenges. First, retention in care ... -
Tracking a sample of patients lost to follow-up has a major impact on understanding determinants of survival in HIV-infected patients on antiretroviral therapy in Africa
(Tropical Medicine & International Health, 2010)Objective: To date, data regarding the determinants of mortality in HIV-infected patients starting antiretroviral therapy (ART) in Africa have been primarily derived from routine clinical care settings practicing the public ... -
Hypoglycemia at admission is associated with inhospital mortality in Ugandan patients with severe sepsis
(Critical care medicine, 2011)Objective—Dysglycemia during sepsis is associated with poor outcomes in resource-rich settings. In resource-limited settings, hypoglycemia is often diagnosed clinically without the benefit of laboratory support. We studied ... -
Aggregate Evaluable Organ Dysfunction Predicts In-Hospital Mortality from Sepsis in Uganda
(The American journal of tropical medicine and hygiene, 2011)We evaluated the association between severity of sepsis and in-hospital mortality in 150 patients with nonsurgical sepsis at a regional referral hospital in Uganda. In-hospital mortality occurred in 5 of 52 (9.6%) patients ... -
Aggregate Evaluable Organ Dysfunction Predicts In-Hospital Mortality from Sepsis in Uganda
(The American journal of tropical medicine and hygiene, 2011)We evaluated the association between severity of sepsis and in-hospital mortality in 150 patients with nonsurgical sepsis at a regional referral hospital in Uganda. In-hospital mortality occurred in 5 of 52 (9.6%) patients ... -
Adding Fuel to the Fire: Alcohol’s Effect on the HIV Epidemic in Sub-Saharan Africa
(Current HIV/AIDS Reports, 2011)Alcohol consumption adds fuel to the HIV epidemic in sub-Saharan Africa (SSA). SSA has the highest prevalence of HIV infection and heavy episodic drinking in the world. Alcohol consumption is associated with behaviors such ... -
Food insecurity, depression and the modifying role of social support among people living with HIV/AIDS in rural Uganda
(Social science & medicine, 2012)Depression is common among people living with HIV/AIDS and contributes to a wide range of worsened HIV-related outcomes, including AIDS-related mortality. Targeting modifiable causes of depression, either through primary ... -
High acceptability for cell phone text messages to improve communication of laboratory results with HIV-infected patients in rural Uganda: a cross-sectional survey study
(BMC medical informatics and decision making, 2012)Background: Patient-provider communication is a major challenge in resource-limited settings with large catchment areas. Though mobile phone usership increased 20-fold in Africa over the past decade, little is known about ... -
A Causal Framework for Understanding the Effect of Losses to Follow-up on Epidemiologic Analyses in Clinic-based Cohorts: The Case of HIV-infected Patients on Antiretroviral Therapy in Africa
(American journal of epidemiology, 2012)Although clinic-based cohorts are most representative of the ‘‘real world,’’ they are susceptible to loss to follow-up. Strategies for managing the impact of loss to follow-up are therefore needed to maximize the value of ... -
Performance of a histidine-rich protein 2 rapid diagnostic test, paracheck pf ® , for detection of malaria infections in Ugandan pregnant women
(The American Society of Tropical Medicine and Hygiene, 2012)Improved laboratory diagnosis is critical to reduce the burden of malaria in pregnancy. Peripheral blood smears appear less sensitive than Plasmodium falciparum histidine-rich protein 2–based rapid diagnostic tests (RDTs) ... -
Short course amphotericin B with high dose fluconazole for HIV-associated cryptococcal meningitis
(Journal of Infection, 2012)Summary Objective: To define more rapidly effective initial antifungal regimens sustainable in resource-constrained settings. Methods: Cohort study in SW Uganda: Thirty HIV-seropositive, antiretroviral therapy-na€ıve, ... -
Optimizing Network Connectivity for Mobile Health Technologies in sub-Saharan Africa
(PLoS ONE, 2012)Background: Mobile health (mHealth) technologies hold incredible promise to improve healthcare delivery in resource limited settings. Network reliability across large catchment areas can be a major challenge. We performed ... -
Contraceptive Use and Associated Factors among Women Enrolling into HIV Care in Southwestern Uganda
(Infectious diseases in obstetrics and gynecology, 2012)Background: Preventing unintended pregnancies among women living with HIV is an important component of prevention of mother-to-child HIV transmission (PMTCT), yet few data exist on contraceptive use among women entering ... -
Diagnosing Kaposi’s Sarcoma (KS) in East Africa: how accurate are clinicians and pathologists?
(Infectious Agents and Cancer, 2012)HIV-associated KS is the most common reported malignancy in sub-Saharan Africa, and appropriate therapy of KS requires accurate diagnosis. In much of the region, however, KS diagnosis is limited to clinical suspicion without ...
