Research Articles: Recent submissions

Now showing items 161-180 of 254

    • The effect of sertraline on depression and associations with persistent depression in survivors of HIV-related cryptococcal meningitis 

      Lofgren, Sarah M.; Velamakanni, Sruti S.; Hullsiek, Katherine Huppler; Bangdiwala, Ananta S.; Namudde, Alice; Musubire, Abdu K.; Mpoza, Edward; Abassi, Mahsa; . Pastick, Katelyn A; Nuwagira, Edwin; Evans, Emily E.; Rajsasingham, Radha; . Williams, Darlisha A; Muzoora, Conrad; Creswell, Fiona V.; Rhein, Joshua; Bond, David J.; Nakasujja, Noeline; Meya, David B.; Boulware, David R. (Wellcome Open Research, 2021)
      Background: Depression is a risk factor for worse outcomes in persons living with HIV/AIDS and has a prevalence more than three times as high as in the general population. Despite this, there are few randomized studies of ...

    • Use, cost-effectiveness, and end user perspectives of a home solar lighting intervention in rural Uganda: a mixed methods, randomized controlled trial 

      Sundararajan, Radhika; D’Couto, Helen; Mugerwa, Joseph; Tayebwa, Mellon; Lam, Nicholas L; Wallach, Eli S; Wiens, Matthew O; Ponticiello, Matthew; Stanistreet, Debbi; Tsai, Alexander C; Vallarino, Jose; Allen, Joseph G; Muyanja, Daniel; Shrime, Mark G; Nuwagira, Edwin; Lai, Peggy S (Environmental Research Letters, 2022)
      Energy poverty is prevalent in resource-limited settings, leading households to use inefficient fuels and appliances that contribute to household air pollution. Randomized controlled trials of household energy interventions ...

    • Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial 

      Rhein, Joshua; Huppler, Kathy; Hullsiek; Tugume, Lillian; Nuwagira, Edwin; Mpoza, Edward (Elsevier, 2019-08)
      Background Identifying new antifungals for cryptococcal meningitis is a priority given the inadequacy of current therapy. Sertraline has previously shown in vitro and in vivo activity against cryptococcus. We aimed to ...

    • Impact of a solar lighting intervention on social determinants of health in rural Uganda: a mixed methods, randomized controlled trial 

      Sundararajan, Radhika; D’Couto, Helen; Mugerwa, Joseph; Tayebwa, Mellon; Lam, Nicholas; Wallach, Eli; Wiens, Matthew; Stanistreet, Debbi; Tsai, Alexander C.; Vallarino, Jose; Allen, Joseph G.; Muyanja, Daniel; Nuwagira, Edwin; Lai, Peggy S. (2021)
      Background. Clinical trials to reduce household air pollution have largely focused on cookstoves and have been in part limited by suboptimal adoption of cleaner cooking technologies. Less is known about the adoption and ...

    • High Mortality Associated with Unmasking Cryptococcal Meningitis 

      Rhein, Joshua; Hullsiek, Kathy Huppler; Bahr, Nathan C; Tugume, Lillian; Nuwagira, Edwin; Ssebambulidde, Kenneth; Kiggundu, Reuben; Evans, Emily E; Mpoza, Edward; Williams, Darlisha A; Abassi, Mahsa; Musubire, Abdu; Muzoora, Conrad; Meya, David B; Boulware, David R (Boston, 2018)
      Introduction: Increased antiretroviral therapy (ART) availability in Africa has led to more patients developing cryptococcosis after ART initiation. Despite this changing epidemiology, data regarding cryptococcal meningitis ...

    • Hearing loss among patients on treatment for drug-resistant tuberculosis in Uganda 

      Lodiong, Lodiong Jackson Dumo; Amos, Timbine; Lumori, Boniface Amanee Elias; Nuwagira, Edwin (South Sudan Medical Journal, 2021-08)
      Introduction: Second-line injectable therapy using aminoglycosides (AG) like kanamycin, amikacin or capreomycin is associated with irreversible hearing loss. We aimed to determine the incidence and predictors of hearing ...

    • Population Pharmacokinetics and Significant Under-Dosing of Anti-Tuberculosis Medications in People with HIV and Critical Illness 

      Rao, Prakruti S.; Moore, Christopher C.; Mbonde, Amir A.; Nuwagira, Edwin; Orikiriza, Patrick; Nyehangane, Dan; Al-Shaer, Mohammad H.; Peloquin, Charles A.; Gratz, Jean; Pholwat, Suporn; Arinaitwe, Rinah; Boum, Yap; Mwanga-Amumpaire, Juliet; Houpt, Eric R.; Kagan, Leonid; Heysell, Scott K.; Muzoora, Conrad (Antibiotics, 2021)
      Critical illness from tuberculosis (TB) bloodstream infection results in a high case fatality rate for people living with human immunodeficiency virus (HIV). Critical illness can lead to altered pharmacokinetics and ...

    • The Changing Epidemiology of HIV-Associated Adult Meningitis, Uganda 2015–2017 

      Ellis, Jayne; Bangdiwala, Ananta S.; Cresswell, Fiona V.; Rhein, Joshua; Nuwagira, Edwin; Ssebambulidde, Kenneth; Tugume, Lillian; Rajasingham, Radha; Bridge, Sarah C.; Muzoora, Conrad; Meya, David B.; Boulware, David R. (In Open forum infectious diseases, 2019)
      Background. Central nervous system (CNS) infections remain a major public health problem in Sub-Saharan Africa, causing 15%–25% of AIDS-related deaths. With widespread availability of antiretroviral therapy (ART) and the ...

    • Gender differences among patients with drug resistant tuberculosis and HIV co‑infection in Uganda: a countrywide retrospective cohort study 

      Baluku, Joseph Baruch; Mukasa, David; Bongomin, Felix; Stadelmann, Anna; Nuwagira, Edwin; Haller, Sabine; Ntabadde, Kauthrah; Turyahabwe, Stavia (BMC Infectious Diseases, 2021)
      Background: Gender differences among patients with drug resistant tuberculosis (DRTB) and HIV co-infection could affect treatment outcomes. We compared characteristics and treatment outcomes of DRTB/HIV co-infected men and ...

    • Standardized Urine-Based Tuberculosis (TB) Screening With TB-Lipoarabinomannan and Xpert MTB/RIF Ultra in Ugandan Adults With Advanced Human Immunodeficiency Virus Disease and Suspected Meningitis 

      Cresswell, Fiona V.; Ellis, Jayne; Kagimu, Enock; Bangdiwala, Ananta S.; Okirwoth, Michael; Mugumya, Gerald; Rutakingirwa, Morris; Kasibante, John; Quinn, Carson M.; Ssebambulidde, Kenneth; Rhein, Joshua; Nuwagira, Edwin; Tugume, Lillian; Martyn, Emily; Skipper, Caleb P.; Muzoora, Conrad; Grint, Daniel; Meya, David B.; Bahr, Nathan C.; Elliott, Alison M.; Boulware, David R. (In Open forum infectious diseases, 2020)
      Background. Diagnosis of extrapulmonary tuberculosis (TB) remains challenging. We sought to determine the prevalence of disseminated TB by testing urine with TB-lipoarabinomannan (TB-LAM) lateral flow assay and Xpert MTB/RIF ...

    • Evaluation of the BioFire FilmArray Meningitis/Encephalitis panel in an adult and pediatric Ugandan population 

      Bridge, Sarah; Hullsiek, Kathy Huppler; Nerima, Carol; Evans, Emily E.; Nuwagira, Edwin; Stadelmana, Anna M.; Trana, Tu; Kim, Grace; Tadeo, Kiiza K.; Kwizera, Richard; Mwesigyea, James; Ellis, Jayne; Cresswell, Fiona V.; Meya, David B.; Muzooraa, Conrad; Boulware, David R.; Rhein, Joshua (Journal of Medical Mycology, 2021)
      Background: Meningitis causes significant mortality in sub-Saharan Africa and limited diagnostics exist. We evaluated the utility of the BioFire_ FilmArray_ Meningitis/Encephalitis multiplex PCR panel (BioFire ME) in ...

    • Drug-Resistant Tuberculosis Presenting as a Testicular Mass: A Case Report 

      Nuwagira, Edwin; Yekosani, Mitala; Abraham, Birungi; Atwine, Raymond; Caleb, Tuhumwire; Baluku, Joseph Baruch (International Medical Case Reports Journal, 2021)
      Background: Extrapulmonary drug-resistant tuberculosis is extremely rare and is almost always associated with poor treatment outcomes. This is partly due to the difficulty in confirming the diagnosis. Case Presentation: ...

    • Renal Tubular Dysfunction Among People Living with HIV on Tenofovir Disoproxil Fumarate in Uganda: A Hospital-Based Cross-Sectional Study 

      Ng'umbi, John Phillip; Nuwagira, Edwin; Kanyesigye, Michael; Muyindike, Winnie; Muhindo, Rose (Reserach square, 2022)
      Background Tenofovir Disoproxil Fumarate (TDF), the most commonly prescribed antiretroviral drug globally is associated with renal tubular dysfunction (RTD) whose magnitude is poorly understood in resource limited settings. ...

    • Detrimental Outcomes of Unmasking Cryptococcal Meningitis With Recent ART Initiation 

      Rhein, Joshua; Hullsiek, Kathy H.; Evans, Emily E.; Tugume, Lillian; Nuwagira, Edwin; Ssebambulidde, Kenneth; Kiggundu, Reuben; Mpoza, Edward; Musubire, Abdu K.; Bangdiwala, Ananta S.; Bahr, Nathan C.; Williams, Darlisha A.; Abassi, Mahsa; Muzoora, Conrad; Meya, David B.; Boulware, David R. (In Open forum infectious diseases, 2018)
      Background: Increased antiretroviral therapy (ART) availability has been associated with more patients developing cryptococcosis after ART initiation. Despite this changing epidemiology, data regarding cryptococcal meningitis ...

    • Obstructive lung disease and quality of life after cure of multi-drug-resistant tuberculosis in Uganda: a cross-sectional study 

      Nuwagira, Edwin; Stadelman, Anna; Baluku, Joseph Baruch; Rhein, Joshua; Byakika-Kibwika, Pauline; Mayanja, Harriet; Kunisaki, Ken M. (Tropical medicine and health, 2020)
      Background: Pulmonary multi-drug-resistant tuberculosis (MDR TB) alters lung architecture and involves lengthy treatment duration, high pill burden, drug adverse effects, travel restrictions, and stigma. Literature about ...

    • Incidence and risk predictors of acute kidney injury among HIV-positive patients presenting with sepsis in a low resource setting 

      Kimweri, Davis; Ategeka, Julian; Ceasor, Faustine; Muyindike, Winnie; Nuwagira, Edwin; Muhindo, Rose (BMC nephrology, 2021)
      Background: Acute kidney injury (AKI) is a frequently encountered clinical condition in critically ill patients and is associated with increased morbidity and mortality. In our resource-limited setting (RLS), the most ...

    • Cryptococcosis in pregnancy and the postpartum period: Case series and systematic review with recommendations for management 

      Pastick, Katelyn A.; Nalintya, Elizabeth; Tugume, Lillian; Ssebambulidde, Kenneth; Stephens, Nicole; Evans, Emily E.; Ndyetukira, Jane Frances; Nuwagira, Edwin; Skipper, Caleb; Muzoora, Conrad; Meya, David B.; Rhein, Joshua; Boulware, David R.; Rajasingham, Radha (Medical Mycology, 2020)
      Cryptococcal meningitis causes 15% of AIDS-related deaths. Optimal management and clinical outcomes of pregnant women with cryptococcosis are limited to case reports, as pregnant women are often excluded from research. ...

    • Cerebrospinal Fluid Lactate as a Prognostic Marker of Disease Severity and Mortality in Cryptococcal Meningitis 

      Abassi, Mahsa; Bangdiwala, Ananta S.; Nuwagira, Edwin; Tadeo, Kiiza Kandole; Okirwoth, Michael; Williams, Darlisha A.; Mpoza, Edward; Tugume, Lillian; Ssebambulidde, Kenneth; Hullsiek, Kathy Huppler; Musubire, Abdu K.; Muzoora, Conrad; Rhein, Joshua; Meya, David B.; Boulware, David R. (Clinical Infectious Diseases, 2021)
      Background: Cerebrospinal fluid (CSF) lactate levels can be used to differentiate between bacterial and viral meningitis. We measured CSF lactate in individuals with cryptococcal meningitis to determine its clinical ...

    • Cerebrospinal Fluid Early Fungicidal Activity as a Surrogate Endpoint for Cryptococcal Meningitis Survival in Clinical Trials 

      Pullen, Matthew F; Hullsiek, Katherine Huppler; Rhein, Joshua; Musubire, Abdu K; Tugume, Lillian; Nuwagira, Edwin; Abassi, Mahsa; Ssebambulidde, Kenneth; Mpoza, Edward; Kiggundu, Ruben; Akampurira, Andrew; Nabeta, Henry W; Schutz, Charlotte; Evans, Emily E; Rajasingham, Radha; Skipper, Caleb P; Pastick, Katelyn A; Williams, Darlisha A; Morawski, Bozena M; Bangdiwala, Ananta S; Meintjes, Graeme; Muzoora, Conrad; Meya, David B; Boulware, David R (Clinical Infectious Diseases, 2020)
      Background: In cryptococcal meningitis phase 2 clinical trials, early fungicidal activity (EFA) of Cryptococcus clearance from cerebrospinal fluid (CSF) is used as a surrogate endpoint for all-cause mortality. The Food and ...

    • Can improved diagnostics reduce mortality from Tuberculous meningitis? Findings from a 6.5-year cohort in Uganda [version 1; referees: awaiting peer review] 

      Cresswell, Fiona V.; Bangdiwala, Ananta S.; Bahr, Nathan C.; Trautner, Emily; Nuwagira, Edwin; Ellis, Jayne; Rajasingham, Radha; Rhein, Joshua; Williams, Darlisha A.; Muzoora, Conrad; Elliott, Alison M.; Meya, David B.; Boulware, David R. (Wellcome Open Research, 2018-05-29)
      Background: Tuberculous meningitis (TBM) is the second most common cause of meningitis in sub-Saharan Africa and is notoriously difficult to diagnose. We describe the impact of improved TBM diagnostics over 6.5 years at ...