Research Articles: Recent submissions
Now showing items 21-40 of 253
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Participant perspectives on incentives for TB preventative therapy adherence and reduced alcohol use: A qualitative study
(PLOS Global Public Health, 2024)Economic incentives to promote health behavior change are highly efficacious for substance use disorders as well as increased medication adherence. Knowledge about participants’ experiences with and perceptions of incentives ... -
Alcohol Consumption in Ugandan HIV-Infected Household-Brewers Versus Non-Brewers
(AIDS and Behavior, 2016)The brewing of alcohol in Ugandan households is common, yet little is known about its relationship with alcohol consumption in HIV-infected individuals. We performed a cross-sectional analysis to assess the association ... -
Alcohol Use and Food Insecurity Among People Living with HIV in Mbarara, Uganda and St. Petersburg, Russia
(AIDS and Behavior, 2017)Food insecurity (FI) is a documented problem associated with adverse health outcomes among HIV-infected populations. Little is known about the relationship between alcohol use and FI. We assessed whether heavy alcohol use ... -
Agreement Between Measures of Adherence to Isoniazid Preventive Therapy Among People With HIV in Uganda
(In Open forum infectious diseases, 2022)Background: Isoniazid (INH) preventative therapy is recommended for people with HIV (PWH) in resource-constrained settings. Valid measures are needed to assess adherence. We aimed to examine agreement between measures ... -
Social Desirability Bias Impacts Self-Reported Alcohol Use Among Persons With HIV in Uganda
(Alcoholism: Clinical and Experimental Research, 2019)Background: Self-report is widely used to assess alcohol use in research and clinical practice, but may be subject to social desirability bias. We aimed to determine if social desirability impacts self-reported alcohol ... -
Unhealthy Alcohol Use Is Associated With Suboptimal Adherence to Isoniazid Preventive Therapy in Persons With HIV in Southwestern Ugand
(JAIDS Journal of Acquired Immune Deficiency Syndromes, 2022)Background: Unhealthy alcohol use is associated with increased progression to tuberculosis (TB) disease, but its effect on adherence to isoniazid (INH) preventive therapy is not known. Methods: This was a prospective ... -
Unhealthy Alcohol Use is Associated with Monocyte Activation Prior to Starting Antiretroviral Therapy
(Clinical and Experimental Research, 2015)Background: Alcohol use may accelerate HIV disease progression, but the plausible biological mechanisms have not been clearly elucidated. Methods: HIV-positive persons who were not on antiretroviral therapy (ART) completed ... -
Alcohol Use and HIV Disease Progression in an Antiretroviral Naive Cohort
(JAIDS Journal of Acquired Immune Deficiency Syndromes, 2018)Background: Alcohol use has been shown to accelerate disease progression in experimental studies of simian immunodeficiency virus in macaques, but the results in observational studies of HIV have been conflicting. Methods: ... -
Alcohol Consumption and Tryptophan Metabolism Among People with HIV Prior to Antiretroviral Therapy Initiation: The Uganda ARCH Cohort Study
(Alcohol and Alcoholism, 2022)Aims: Alcohol is hypothesized to have effects on the kynurenine pathway of tryptophan catabolism, a potential mechanism for alcohol-induced depression and aggression. A biomarker of this pathway, the plasma kynurenine to ... -
Association between smoking and lack of HIV virological suppression in a cross-sectional study of persons with HIV on antiretroviral therapy in Uganda
(PLoS ONE, 2024)Background: Smoking and alcohol use frequently co-occur and are the leading causes of preventable death in sub-Saharan Africa (SSA) and are common among people living with HIV (PLWH). While alcohol use has been shown to ... -
Real-world use and outcomes of dolutegravir-containing antiretroviral therapy in HIV and tuberculosis co-infection: a site survey and cohort study in sub-Saharan Africa
(Journal of the International AIDS Society, 2022)Introduction: Dolutegravir is being scaled up globally as part of antiretroviral therapy (ART), but for people with HIV and tuberculosis co-infection, its use is complicated by a drug–drug interaction with rifampicin ... -
A prospective ascertainment of cancer incidence in sub- Saharan Africa: The case of Kaposi sarcoma
(Cancer medicine, 2016)In resource- limited areas, such as sub- Saharan Africa, problems in accurate cancer case ascertainment and enumeration of the at- risk population make it difficult to estimate cancer incidence. We took advantage of a large ... -
Toward an Understanding of Disengagement from HIV Treatment and Care in Sub-Saharan Africa: A Qualitative Study
(PLoS medicine, 2013)Background: The rollout of antiretroviral therapy in sub-Saharan Africa has brought lifesaving treatment to millions of HIVinfected individuals. Treatment is lifelong, however, and to continue to benefit, patients must ... -
Traditional healer-delivered point-of-care HIV testing versus referral to clinical facilities for adults of unknown serostatus in rural Uganda: a mixed-methods, cluster-randomised trial
(The Lancet Global Health, 2021)Background: HIV counselling and testing are essential to control the HIV epidemic. However, HIV testing uptake is low in sub-Saharan Africa, where many people use informal health-care resources such as traditional healers. ... -
Tuberculin skin test positivity among HIVinfected alcohol drinkers on antiretrovirals in south-western Uganda
(PloS one, 2020)Background: Tuberculosis (TB) is the leading cause of death among people living with HIV (PLWH), and current evidence suggests that heavy alcohol users have an increased risk of developing TB disease compared to non-drinkers. ... -
Unhealthy alcohol use and intimate partner violence among men and women living with HIV in Uganda.
(BMC public health, 2022)Background: Intimate partner violence (IPV) and alcohol use are interrelated public health issues. Heavy and frequent alcohol use increase the risk of IPV, but the relationship between alcohol use and IPV (including recent ... -
Development and Validation of the East Africa Alcohol Expectancy Scale (AFEXS)
(Journal of studies on alcohol and drugs, 2015)Objective: The purpose of this study was to develop and validate the East Africa Alcohol Expectancy Scale (AFEXS), a measure of alcohol expectancies for use with HIV-positive adults in East Africa. Method: The study was ... -
Quantifying the burden of cardiovascular diseases among people living with HIV in sub-Saharan Africa: Findings from a modeling study for Uganda
(Journal of Global Health Reports, 2020)Background: The burden of non-communicable diseases (NCDs) is rapidly increasing in low- and middle-income countries, but remains largely unknown among people living with HIV (PLWH) in most sub-Saharan African countries. ... -
Prevalence of elevated liver transaminases and their relationship with alcohol use in people living with HIV on anti-retroviral therapy in Uganda
(PloS one, 2021)Background: Isoniazid preventive therapy (IPT) reduces tuberculosis reactivation and mortality among persons living with HIV (PLWH), yet hepatotoxicity concerns exclude “regular and heavy alcohol drinkers” from IPT. We ... -
Post-traumatic stress disorder among persons with HIV who engage in heavy alcohol consumption in southwestern Uganda
(BMC psychiatry, 2021)Background: We aimed to describe the prevalence of PTSD symptoms and its associated factors in persons living with HIV (PLWH) in Uganda who engage in heavy alcohol use. Methods: We analyzed baseline data from the Drinkers ...