dc.contributor.author | Okello, Samson | |
dc.contributor.author | Nasasira, Benson | |
dc.contributor.author | Muiru, Anthony Ndichu Wa | |
dc.contributor.author | Muyingo, Anthony | |
dc.date.accessioned | 2022-02-03T06:58:33Z | |
dc.date.available | 2022-02-03T06:58:33Z | |
dc.date.issued | 2016-07-01 | |
dc.identifier.citation | Okello S, Nasasira B, Muiru ANW, Muyingo A (2016) Validity and Reliability of a Self-Reported Measure of Antihypertensive Medication Adherence in Uganda. PLoS ONE 11(7): e0158499. doi:10.1371/ journal.pone.0158499 | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/1371 | |
dc.description.abstract | Background: The Morisky Medication Adherence scale (MMAS-8) is a widely used self-reported measure of adherence to antihypertensive medications that has not been validated in hypertensive
patients in sub-Saharan Africa.
Methods: We carried out a cross-sectional study to examine psychometric properties of a translated MMAS-8 (MMAS-U) in a tertiary care hypertension clinic in Uganda. We administered the MMAS-U to consecutively selected hypertensive adults and used principal factor analysis and Cronbach’s alpha to determine its validity and internal consistency respectively. Then we randomly selected one-sixth of participants for a 2-week test-retest telephone interview. Lastly, we used ordinal logistic regression modeling to explore factors associated with levels of medication adherence.
Results: Of the 329 participants, 228 (69%) were females, median age of 55 years [Interquartile
range (IQR) (46–66)], and median duration of hypertension of 4 years [IQR (2–8)]. The adherence levels were low (MMAS-U score _ 5) in 85%, moderate (MMAS-U score 6–7) in 12% and high (MMAS-U score _8) in 3%. The factor analysis of construct validity was good (overall Kaiser’s measure of sampling adequacy for residuals of 0.72) and identified unidimensionality of MMAS-U. The internal consistency of MMAS-U was moderate (Cronbach α = 0.65), and test-retest reliability was low (weighted kappa = 0.36; 95% CI -0.01, 0.73). Age of 40 years or greater was associated with low medication adherence (p = 0.02) whereas a family member buying medication for participants (p = 0.02) and purchasing me
Conclusion: The Ugandan version of the MMAS-8 (MMAS-U) is a valid and reliable measure of adherence to antihypertensive medication among Ugandan outpatients receiving care at a public
tertiary facility. Though the limited supply of medication affected adherence, this easy to use tool can be adapted to assess medication adherence among adults with hypertension in Uganda.dication from a private clinic (p = 0.02) were associated with high adherence. | en_US |
dc.description.sponsorship | Bernard Lown Scholars in Cardiovascular Health Program at Harvard T.H. School of Public Health, Boston, MA, USA. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PLoS ONE | en_US |
dc.subject | Validity and Reliability | en_US |
dc.subject | Antihypertensive Medication | en_US |
dc.subject | Adherence | en_US |
dc.subject | Hypertensive patients | en_US |
dc.subject | Sub-Saharan Africa | en_US |
dc.subject | Uganda | en_US |
dc.title | Validity and Reliability of a Self-Reported Measure of Antihypertensive Medication Adherence in Uganda | en_US |
dc.type | Article | en_US |