dc.contributor.author | Lee, Guinevere Q. | |
dc.contributor.author | Lachowski, Chris | |
dc.contributor.author | Cai, Eric | |
dc.contributor.author | Lima, Viviane D. | |
dc.contributor.author | Boum, Yap | |
dc.contributor.author | Muzoora, Conrad | |
dc.contributor.author | Mocello, A. Rain | |
dc.contributor.author | Hunt, Peter W. | |
dc.contributor.author | Martin, Jeffrey N. | |
dc.contributor.author | Bangsberg, David R. | |
dc.contributor.author | Harrigan, P. Richard | |
dc.date.accessioned | 2022-06-14T12:40:15Z | |
dc.date.available | 2022-06-14T12:40:15Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Lee, G. Q., Lachowski, C., Cai, E., Lima, V. D., Boum, Y., Muzoora, C., ... & Harrigan, P. R. (2016). Non-R5-tropic HIV-1 in Subtype A1 and D Infections Were Associated with Lower Pre-therapy CD4 Count But Not with PI/(N) NRTI Therapy Outcomes in Mbarara, Uganda. AIDS (London, England), 30(11), 1781. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/2126 | |
dc.description.abstract | Background: Previous studies suggest that infection with non-R5-tropic subtype B HIV-1, compared to R5, is associated with a more rapid decline in CD4 count, but does not affect PI/(N)NRTI therapy outcome. Here, we explored clinical correlates associated with viral tropism in subtype A1 and D infections.
Methods: HIV-1 subtype A1 (n=196) and D (n=143) pre-therapy plasma samples and up to 7.5 years of post-therapy virologic and CD4 data were collected from a cross-sectional cohort in Mbarara, Uganda. Tropism and subtype were inferred using env V3 (geno2pheno) and gp41 (RIP) Sanger sequences. For each subtype, R5 infection was compared with non-R5 in terms of: Pre-therapy viral load and CD4 count (Mann-Whitney tests), and therapy outcomes including time to virologic suppression, post-suppression virologic rebound, CD4 decline and CD4 recovery (Log-rank tests).
Results: 94% of all patients in this study achieved virologic suppression within median 3 months post-therapy. In both subtypes, non-R5 infection was associated with lower pre-therapy CD4 count (non-R5 versus R5; A: median 57 versus 147 cells/μL p=0.005; D: 80 versus 128 cells/μL p=0.006). Multivariable linear regression confirmed that tropism, not subtype nor the interaction between subtype and tropism, was a significant predictor of pre-therapy CD4 count
(p<0.0001). None of pre-therapy viral load, time to virologic suppression, virologic rebound, CD4 decline nor CD4 recovery was significantly different (all p>0.09).
Conclusion: Regardless of HIV-1 subtype or tropism, the majority of patients in this Ugandan cohort responded to therapy, even though non-R5 infection was associated with lower pre-therapy CD4 count. | en_US |
dc.description.sponsorship | Canadian Institutes of Health Research (CIHR), National Institutes of Health (NIH) Centers for AIDS Research (CFAR) Program,National Institute of Mental Health R01MH054907, P30AI027763, U01CA066529 and National Institute on Alcohol Abuse and Alcoholism R21AA014784. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | AIDS | en_US |
dc.subject | Uganda | en_US |
dc.subject | Africa | en_US |
dc.subject | Subtype A1 | en_US |
dc.subject | Subtype D | en_US |
dc.subject | Non-B tropism | en_US |
dc.subject | Virologic outcome | en_US |
dc.subject | Consequence | en_US |
dc.subject | HIV-1 | en_US |
dc.subject | Clinical outcome | en_US |
dc.title | Non-R5-tropic HIV-1 in Subtype A1 and D Infections Were Associated with Lower Pre-therapy CD4 Count But Not with PI/(N)NRTI Therapy Outcomes in Mbarara, Uganda | en_US |
dc.type | Article | en_US |