dc.contributor.author | Lumori, Boniface Amanee Elias | |
dc.contributor.author | Muyanja, Daniel | |
dc.date.accessioned | 2022-07-19T08:21:23Z | |
dc.date.available | 2022-07-19T08:21:23Z | |
dc.date.issued | 2019-01-13 | |
dc.identifier.citation | Lumori, B. A. E., & Muyanja, D. (2019). Diagnostic and Treatment Challenges of Paroxysmal Nocturnal Hemoglobinuria in Uganda. Case Reports in Hematology, 2019. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/2245 | |
dc.description.abstract | Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disorder of the hematopoietic stem cells which is often underdiagnosed. Its incidence is about 5 cases per million inhabitants in a year, and currently, there are only 1610 patients in the International PNH Registry. In this report, we describe a case of PNH in southwestern Uganda.
Case Presentation: A 34-year-old man, subsistence farmer, with a history of multiple prior presentations with anemia, jaundice, and dark-colored urine requiring blood transfusions presented to us again in July 2018 with a week’s history of palpitations, dizziness, and dark-colored urine. Investigations done suggested a direct antiglobulin test- (DAT-) negative hemolytic anemia, and subsequently, flow cytometry showed a large clone of PNH. He received many blood transfusions and hematinics on several occasions during the course of his admissions.
Conclusions: Our report showed diagnostic and treatment challenges of PNH in health resource-limited setting. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Case Reports in Hematology | en_US |
dc.subject | Paroxysmal nocturnal hemoglobinuria | en_US |
dc.subject | Underdiagnosed | en_US |
dc.subject | Uganda | en_US |
dc.subject | Treatment Challenges | en_US |
dc.title | Diagnostic and Treatment Challenges of Paroxysmal Nocturnal Hemoglobinuria in Uganda | en_US |
dc.type | Article | en_US |