dc.contributor.author | Kyagambiddwa, Tonny | |
dc.contributor.author | Kintu, Timothy Mwanje | |
dc.contributor.author | Miiro, Emmanuel | |
dc.contributor.author | Nabalamba, Franchesca | |
dc.contributor.author | Asiimwe, Gloria Suubi | |
dc.contributor.author | Namutebi, Anne Marion | |
dc.contributor.author | Abeya, Fardous C | |
dc.contributor.author | Lumori, Boniface A | |
dc.contributor.author | Ijuka, Isaac | |
dc.contributor.author | Muhindo, Rose K | |
dc.contributor.author | Mutekanga, Andrew | |
dc.contributor.author | Musinguzi, Richard | |
dc.contributor.author | Natuhwera, Francis | |
dc.contributor.author | Ngonzi, Joseph | |
dc.contributor.author | Nuwagira, Edwin | |
dc.date.accessioned | 2023-05-15T12:53:18Z | |
dc.date.available | 2023-05-15T12:53:18Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Kyagambiddwa, T., Kintu, T. M., Miiro, E., Nabalamba, F., Asiimwe, G. S., Namutebi, A. M., ... & Nuwagira, E. (2023). Thirty-Day Outcomes of Young and Middle-Aged Adults Admitted with Severe COVID-19 in Uganda: A Retrospective Cohort Study. Infection and Drug Resistance, 2923-2932. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/2915 | |
dc.description.abstract | Background: There is scarcity of data regarding young and middle-aged adults hospitalized with severe Corona Virus Disease 2019 (COVID-19) in Africa. In this study, we describe the clinical characteristics and 30-day survival among adults aged 18 to 49 years admitted with severe COVID-19 in Uganda.
Methods: We reviewed treatment records of patients admitted with severe COVID-19 across five COVID-19 treatment units (CTU) in Uganda. We included individuals aged 18 to 49 years, who had a positive test or met the clinical criteria for COVID-19. We defined severe COVID-19 as having an oxygen saturation <94%, lung infiltrates >50% on imaging and presence of a co-morbidity that required admission in the CTU. Our main outcome was the 30-day survival from the time of admission. We used a Cox proportional hazards model to determine the factors associated with 30-day survival at a 5% level of significance.
Results: Of the 246 patient files reviewed, 50.8% (n = 125) were male, the mean ± (standard deviation) age was 39 ± 8 years, majority presented with cough, 85.8% (n = 211) and median C-reactive protein (interquartile range) was 48 (47.5, 178.8) mg/L. The 30-day mortality was 23.9% (59/246). At admission, anemia (hazard ratio (HR): 3.00, 95% confidence interval (CI), 1.32–6.82; p = 0.009) and altered mental state (GCS <15) (HR: 6.89, 95% CI: 1.48–32.08, p = 0.014) were significant predictors of 30-day mortality.
Conclusion: There was a high 30-day mortality among young and middle-aged adults with severe COVID-19 in Uganda. Early recognition and targeted management of anemia and altered consciousness are needed to improve clinical outcomes | en_US |
dc.description.sponsorship | Seed grant | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Infection and Drug Resistance | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Uganda | en_US |
dc.subject | Mortality | en_US |
dc.subject | Young and middle-aged adults | en_US |
dc.title | Thirty-Day Outcomes of Young and Middle-Aged Adults Admitted with Severe COVID-19 in Uganda: A Retrospective Cohort Study | en_US |
dc.type | Article | en_US |