Department of Pharmacy: Recent submissions
Now showing items 101-120 of 182
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A method for the analysis of sugars in biological systems using reductive amination in combination with hydrophilic interaction chromatography and high resolution mass spectrometry
(Talanta, 2017)Separation of sugar isomers extracted from biological samples is challenging because of their natural occurrence as alpha and beta anomers and, in the case of hexoses, in their pyranose and furanose forms. A reductive ... -
Registration and local production of essential medicines in Uganda
(Journal of Pharmaceutical Policy and Practice, 2020)Background: Universal access to high quality essential medicines is critical to sustainable development (SDG 3.8). However low- and middle-income countries struggle to ensure access to all medicines on their national ... -
Phytochemical constituents found in Physalis peruviana L. leaf extracts and their ability to inhibit alpha-glucosidase and scavenge DPPH free radicals in vitro
(Trends in Phytochemical Research (TPR, 2022-03-28)Physalis peruviana L. is widely used in folk medicines to manage diabetes. This study aimed to identify new chemical constituents and explore in vitro antioxidant ability and alpha-glucosidase inhibition activity to explain ... -
Metabolomic Profiling of the Effects of Melittin on Cisplatin Resistant and Cisplatin Sensitive Ovarian Cancer Cells Using Mass Spectrometry and Biolog Microarray Technology
(Metabolites, 2017)In the present study, liquid chromatography-mass spectrometry (LC-MS) was employed to characterise the metabolic profiles of two human ovarian cancer cell lines A2780 (cisplatin-sensitive) and A2780CR (cisplatin-resistant) ... -
Factors Associated With Non-Adherence To Antidiabetic Medication Among Patients at Mbarara Regional Referral Hospital, Mbarara, Uganda
(Research square, 2021)Background: Non–adherence is a major concern in treatment of diabetes mellitus and undermines the goals of treatment. The objective of this study was to determine the magnitude of non-adherence and its contributing factors ... -
Natural Vaccine Adjuvants and Immunopotentiators Derived From Plants, Fungi, Marine Organisms, and Insects
(In Immunopotentiators in Modern Vaccines, 2017)Secondary metabolites from natural sources have made a significant contribution to medicine for millennia. In modern medicine, drugs developed from natural products have been used to treat infectious diseases, cancer, ... -
A Study of the Biological Activity of Bee Venom and its Fractions With Regard to Cosmetic Science and Immunology
(University of Strathclyde Science, 2016)Apis mellifera venom has been used since antiquity to treat various ailments but sci-entific evidence to justify its therapeutic claims is incomplete. The venom has recent-ly entered cosmetic usage as a mimetic ingredient ... -
An LCMS method for the assay of melittin in cosmetic formulations containing bee venom
(Analytical and Bioanalytical Chemistry, 2015)There is a growing interest in the potential of bee venom in cosmetics as a rejuvenating agent. Products currently on the market do not specify exactly their content of bee venom (BV). Therefore, we developed a method for ... -
Effect of Bee Venom and Its Fractions on the Release of Pro-Inflammatory Cytokines in PMA-Differentiated U937 Cells Co-Stimulated with LPS
(Vaccines, 2016-04-19)The venom of Apis mellifera (honey bee) has been reported to play a role in immunotherapy, but existing evidence to support its immuno-modulatory claims is insufficient. Four fractions from whole bee venom (BV) were separated ... -
Chemical constituents and evidence-based pharmacological properties of Physalis peruviana L.: An overview
(Journal of Herbmed Pharmacology, 2021)Physalis peruviana L. is among plant species possessing evident nutritional, nutraceutical, and commercial interests. This review highlights the complexity of the chemical composition supporting the multiple pharmacotherapeutic ... -
Prevalence and factors associated with adverse drug events among patients on dolutegravir‑based regimen at the Immune Suppression Syndrome Clinic of Mbarara Regional Referral Hospital, Uganda: a mixed design study
(AIDS Research and Therapy, 2022)Background: In low income countries such as Uganda progress has been made towards achieving the United Nations AIDS programme 95-95-95 target however efforts are still impeded by pretreatment drug resistance and adverse ... -
Antipyretic and Antinociceptive Properties of the Aqueous Extract and Saponin from an Edible Vegetable- Vernonia Amygdalina Leaf
(African Journal of food, agriculture, nutrition and development, 2013)Vernonia amygdalina is commonly used for food and health purposes. The processing of the leaf for food is usually aimed at removing bitter tasting principles like saponins. This study was designed to determine the antipyretic ... -
Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?
(World journal of pharmacology,, 2014)Artemisinin from the plant Artemisia annua (A. annua) L., and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in ... -
Acute and sub-acute oral toxicity of aqueous whole leaf and green rind extracts of Aloe vera in Wistar rats
(BMC complementary medicine and therapies, 2022)Background: Several local communities in Central, Western, Eastern, and Northern regions of Uganda have been using the whole leaf extracts of Aloe vera (L.) Burm. f. (Asphodelaceae) in the treatment of various ailments. ... -
Safety and Efficacy of Medicinal Plants Used to Manufacture Herbal Products with Regulatory Approval in Uganda: A Cross-Sectional Study
(Evidence-Based Complementary and Alternative Medicine, 2022)Introduction: Uganda National Drug Authority requires phytochemical screening, freedom from microbial contamination, and evidence of safety and efficacy of the constituent plants to register herbal products. Since Uganda ... -
Potential drug-drug interactions on in-patient medication prescriptions at Mbarara Regional Referral Hospital (MRRH) in western Uganda: prevalence, clinical importance and associated factors
(African Health Sciences, 2011)Background: Drug-drug interactions (DDIs) are an important cause of adverse drug reactions. The pharmacoepidemiology of such interactions in hospitals in Uganda is not known. Objectives: To determine the prevalence, ... -
Inappropriate usage of selected antimicrobials: Comparative residue proportions in rural and urban beef in Uganda
(PloS one, 2019)Introduction In most developing countries like Uganda, antimicrobials including β-lactams and tetracyclines are used indiscriminately in livestock. When livestock get sick and treatment is necessary, some producers and ... -
Prevalence and risk factors of nephrotoxicity among adult cancer patients at Mbarara regional referral hospital
(Dove Medical Press Limited., 2021-10-17)Background: Nephrotoxicity is common among cancer patients, yet some anti-cancer drugs, for example, platinum derivatives, are nephrotoxic and have narrow therapeutic indices. If nephrotoxicity is not managed, it can ... -
Artemisia annua L.- Vernonia amygdalina Del: A Potential Herbal Artemisinin Combination Treatment against Malaria
(British Journal of Pharmaceutical Research, 2016-01)Aim of Study: The aim of the study was to determine the potential of Vernonia amygdalina - Artemisia annual combination as a possible herbal artemisinin combination treatment of malaria. Place and Duration of Study: Study ...