Department of Pharmacy: Recent submissions
Now showing items 121-140 of 182
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Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial
(Malaria journal, 2012-05)Background: Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, randomized controlled trial in Mbarara, Uganda ... -
Potential benefits of antiviral African medicinal plants in the management of Viral infections
(Frontiers in Pharmacology, 2021-12-24)Background: Viruses cause various human diseases, some of which become pandemic outbreaks. This study synthesized evidence on antiviral medicinal plants in Africa which could potentially be further studied for viral ... -
Antifungal activity of Cleome gynandra L. aerial parts for topical treatment of Tinea capitis: an in vitro evaluation
(Complementary and Alternative Medicine, 2016-07)Background: Cleome gynandra L. (Capparaceae) is an edible weed used in Uganda topically for its presumed antifungal activity against Tinea capitis. The goal of this study was to determine if this plant possesses antifungal ... -
Poor Glycemic Control and the Contributing Factors Among Type 2 Diabetes Mellitus Patients Attending Outpatient Diabetes Clinic at Mbarara Regional Referral Hospital, Uganda
(2021)Background: Glycemic control is associated with long-term complications in type 2 diabetes management. However, updated reports on glycemic control that are crucial to reducing diabetes mellitus complications remain ... -
Phytochemical and Antidiabetic Evaluation of the Methanolic Stem Bark Extract of Spathodea campanulata (P. Beauv.) Bignoniaceae
(Pharmacognosy Journal, 2016-05)Background: Spathodea campanulata (P. Beauv.) Bignoniaceae extract (SCE) is one of many herbal medicines used widely in Ugandan traditional medicine for various ailments. Generally most of these herbal medicines are yet ... -
Infections
(African Health Sciences, 2011-09)Background: Medicinal plants in Uganda and other developing countries have been scientifically demonstrated to have medicinal benefits but few or none have been translated to products for clinical use. Most herbal products ... -
Antisickling effect of crude flavonoids in the methanolic leaf extract of Persea americana Mill
(Revista Cubana de Plantas Medicinales, 2019-06)Introduction: Sickle-cell anemia, a difficult-to-treat genetic disease, causes synthesis of abnormal hemoglobin in which erythrocytes assume a sickle shape and become susceptible to hemolysis. Research about Persea americana ... -
Anticonvulsant and anxiolytic activity of the leaf aqueous and ethanolic extracts of Melanthera scandens in a rat model
(HHS Public Access, 2016)Modern drug therapy of epilepsy is complicated by the inability of drugs to control seizures in some patients and side effects that range in severity from minimal impairment of the central nervous system to death from ... -
Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents
(Pharmacology & Pharmacy, 2018)Oral lesions, diarrhoea, Pneumocystis carinii pneumonia, tuberculosis and urinary tract infections are some of the opportunistic infections (OIs) which arise when the CD4 cells of the HIV/AIDS patient fall below 200 ... -
Aflatoxins metabolism, effects on epigenetic mechanisms and their role in carcinogenesis
(SciRes, 2013)Chronic consumption of aflatoxin-contaminated foods is a global problem in both developing and developed countries especially where there is poor regulation of their levels in foods. In the body, aflatoxins (AFBs) mainly ... -
An investigation into the number and nature of the urgent care consultations managed and referred by community pharmacists in South-East England
(Primary Health Care Research & Development, 2020)Background: Community pharmacies are recognised as an under-utilised, accessible resource that could support the urgent care agenda. This study aimed to provide a snapshot of the number and nature of urgent care requests ... -
Adverse drug reaction reporting among health care workers at Mulago National Referral and Teaching hospital in Uganda
(African Health Sciences, 2015)Background: Adverse Drug Reactions (ADRs) are an important contributor to patient morbidity and hospitalisation in Uganda. Under-reporting of ADRs may increase medicine-induced morbidity and mortality among patients. This ... -
Poor glycemic control and the contributing factors among type 2 diabetes mellitus patients attending outpatient diabetes clinic at Mbarara regional referral hospital, Uganda
(Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2021)Background: Glycemic control is associated with long-term complications in type 2 diabetes management. However, updated reports on glycemic control that are crucial to reducing diabetes mellitus complications remain scarce. ... -
Physical properties and compactability of various blends of fully gelatinised and pregelatinised maize starch
(Pharmaceutical and Biosciences Journal, 2020)The use of pregelatinised maize starch in direct compression as a sole binder produces tablets with relatively low tensile strength. Fully gelatinised maize starch possesses better binding properties but its use is limited ... -
Pharmacology, phytochemistry, and toxicity profiles of phytolacca dodecandra L’Hér
(Infectious Diseases: Research and Treatment, 2020)Introduction: Phytolacca dodecandra L’Hér. is a native plant of sub-Saharan Africa and Madagascar which is traditionally used for various ailments. Concerned with the scope of the available evidence, we designed a scoping ... -
Pharmacological reflection of plants traditionally used to manage diabetes mellitus in Tanzania
(Journal of Ethnopharmacology, 2020-12-25)Ethnopharmacological relevance: The increasing national prevalence of diabetes mellitus (DM) and its complications have overstretched the health care system in Tanzania and influenced patients to use herbal medicines as ... -
Pharmacognostic, antiplasmodial and antipyretic evaluation of the aqueous extract of Vernonia amygdalina leaf
(Int. J. Biol. Chem. Sci., 2011)The impeding safety challenges to the use of herbs have made qualitative and quantitative evaluation of herbal preparations a necessity. This study was aimed at evaluating the pharmacognostic and pharmacological properties ... -
Effect of high-dose rifampicin on efavirenz pharmacokinetics: drug–drug interaction randomized trial
(Journal of Antimicrobial Chemotherapy, 2020-01)Background: High-dose rifampicin is considered to shorten anti-TB treatment duration but its effect on antiretroviral metabolism is unknown. Objectives: To assess the effect of doubling the rifampicin dose (to 20 mg/kg/day, ... -
Efficacy of Commercially Used Antibacterial Agents against Oral Bacteria Associated with HIV/AIDS Patients in South Western Uganda
(British Journal of Pharmaceutical Research, 2017-05)Aims: This was to determine efficacy and resistance profiles against commonly used commercial antibacterial agents in Uganda in the management of oral pathogens in HIV/AIDS patients. Study Design: This was an experimental ... -
Drugs in Clinical Practice from Toxic Plants and Phytochemicals
(Poisonous Plants and Phytochemicals in Drug Discovery, 2020)