Department of Pharmacy: Recent submissions
Now showing items 61-80 of 182
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Review of Deforestation in Ugandan Tropical Rainforest Reserves: A Threat to Natural Medicine
(East African Journal of Environment and Natural Resources, 2022)Deforestation in Ugandan Tropical Rainforest Reserves as threat to natural medicine is still undocumented. In this study, we reviewed literature on deforestation most especially from 1990-2020 in the Tropical Rainforest ... -
In-vitro antihelminthic activity of alcoholic extract from Paullinia pinnata Linn against Ascaris suum
(Revista Cubana de Plantas Medicinales, 2018)Introduction: Medicinal plants are used both for the treatment of certain conditions and to preserve health and vitality. According to estimates by the World Health Organization, 80% of the world population, excluding ... -
Identification of Antimicrobial Peptides Isolated From the Skin Mucus of African Catfish, Clarias gariepinus (Burchell, 1822)
(Frontiers in microbiology, 2021)Antimicrobial peptides (AMPs) constitute a broad range of bioactive compounds in diverse organisms, including fish. They are effector molecules for the innate immune response, against pathogens, tissue damage and infections. ... -
Evaluation of Cafeteria Diet in Experimental Animal with Plant Extract of Calotropis procera for Obesity Parameter
(Journal for Research in Applied Sciences and Biotechnology, 2022)The function of obesity in an insulin-resistant syndrome associated with hyper insulinemia, hypertension, hyperlipidemia, atherosclerotic diseased illness is vital. Hunger, body weight and lipid profile investigations thus ... -
Traditional Approaches and Medicinal Plants in Treatment of Epilepsy in West and East Africa
(NeuroPharmac Journal, 2020)Background: Epilepsy has affected over sixty million people around the globe. Traditionally, communities have opted for complementary and alternative medicines (CAM) to help in the treatment of epilepsy which has worked ... -
Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda
(TMR Integrative Medicine, 2023)Different parts of Artemisia vulgaris L. (A. vulgaris) are ethno-medicinally used as an emmenagogue and for the treatment of ailments such as malaria fever, ulcers, and cancer. However, anecdotal evidence shows that the ... -
ADMET profiling and molecular docking of potential antimicrobial peptides previously isolated from African catfish, Clarias gariepinus
(Frontiers in Molecular Biosciences, 2022)Amidst rising cases of antimicrobial resistance, antimicrobial peptides (AMPs) are regarded as a promising alternative to traditional antibiotics. Even so, poor pharmacokinetic profiles of certain AMPs impede their utility ... -
Retrospective in silico mutation profiling of SARS-CoV-2 structural proteins circulating in Uganda by July 2021: Towards refinement of COVID-19 disease vaccines, diagnostics, and therapeutics
(Plos one, 2022)The SARS-CoV-2 virus, the agent of COVID-19, caused unprecedented loss of lives and economic decline worldwide. Although the introduction of public health measures, vaccines, diagnostics, and therapeutics disrupted the ... -
SARS-CoV-2 vaccine development
(Coronavirus Drug Discovery, 2022)Vaccine development is the entire process involved in the designing of a vaccine to the post release study period. Vaccines work against viruses, bacteria, fungi and parasites. The design in which an antiviral vaccine is ... -
Effect of Covid-19 in Management of Lung Cancer Disease: A Review
(Asian Journal of Pharmaceutical Research and Development, 2022)COVID-19 outcomes may be more severe in lung cancer patients. As a COVID-19 pandemic spreads, it's critical to identify which people and malignancies are most susceptible. COVID-19 appears to have the worst results in lung ... -
Potentially harmful medication use and the associated factors among pregnant women visiting antenatal care clinics in Mbarara Regional Referral Hospital, Southwestern Uganda
(Journal of Clinical and Translational Research, 2023)Background: Pregnancy management using medications has been challenging for both healthcare providers and pregnant women, given the fear of teratogenicity effects and the potential for fetal harm. In the developing world, ... -
Association between Pre-Hospital Antibiotic Exposure and Level of Bacterial Resistance (PHAE Study): A Matched Case Control Study at the Medical and Paediatric wards of Mbarara Regional Referral Hospital-South Western Uganda
(Research square, 2022-09-07)Background: This study aimed to determine the association between pre-hospital antibiotic exposure and level of bacterial resistance among adult and paediatric patients. Methods: In the study, 79 antibiotic pre-exposed ... -
Ligand-protein interactions of plant-isolated (9z,12z)-octadeca-9,12-dienoic acid with B-ketoacyl-Acp synthase (KasA) in potential anti-tubercular drug designing
(Scientific African, 2021)Mycobacterium tuberculosis remains one of the world’s contributors to mortality. With the emergence of SARS-CoV-2 coinfections, patients with TB are predisposed to being more heavily weighed down by COVID-19 disease and ... -
Therapeutic potentials of Vachellia nilotica (L.) extracts in Hepatitis C infection: A review
(Scientific African, 2021)Hepatitis C Virus (HCV) infection represents a huge burden on healthcare systems world- wide. Vachellia nilotica ( V. nilotica ) is a widely used plant specie in folk medicine for viral diseases and in some communities for ... -
New Putative Antimicrobial Candidates: In silico Design of Fish-Derived Antibacterial Peptide-Motifs
(Frontiers in Bioengineering and Biotechnology, 2020)Antimicrobial resistance remains a great threat to global health. In response to the World Health Organizations’ global call for action, nature has been explored for novel and safe antimicrobial candidates. To date, fish ... -
Human Health Risk Assessment of Heavy Metals in Kampala (Uganda) Drinking Water
(Journal of Food Research, 2022)Levels of aluminium, arsenic, cadmium, chromium, copper, iron, mercury, manganese, nickel, lead and zinc in tap water, groundwater-fed protected spring and bottled water were determined. The cancer and non-cancer risks ... -
General Extraction, Isolation and Characterization Techniques in Drug Discovery: A Review
(International Journal of Sciences: Basic and Applied Research (IJSBAR), 2018)Extraction, isolation and characterization techniques of compounds from plant tissues are the basic foundations of drug discovery from plants. Research has been conducted using these techniques and publications are available ... -
Fundamental Methods in Drug Permeability, pKa, LogP and LogDx Determination
(Journal of Drug Research and Development, 2018)Potential drug molecular leads from plants are usually tested for their efficacy in bioactivity assays in preclinical trials. This is followed by testing for the properties of the molecular structures, if they can be ... -
Fish Mucus- a Neglected Reservoir For Antimicrobial Peptides
(Asian Journal of Pharmaceutical Research and Development, 2018)Antimicrobial resistance has posed a great global burden, with the fear that by 2050 it would have killed more people than cancer if nothing much is done about it. Alongside several attempts in place, zoo-therapy is becoming ... -
Drug-like properties of anticancer molecules elucidated from Eichhornia crassipes
(Journal of Pharmacognosy and Phytochemistry, 2018)Eichhornia crassipes is reported to have molecules that are active against liver, cervical, breast cancers and melanoma cells. This systematic review was conducted according to Cochrane hand book of systematic review and ...