Browsing Department of Internal Medicine by Author "Abassi, Mahsa"

Now showing items 1-13 of 13

    • Cerebrospinal Fluid Early Fungicidal Activity as a Surrogate Endpoint for Cryptococcal Meningitis Survival in Clinical Trials 

      Pullen, Matthew F; Hullsiek, Katherine Huppler; Rhein, Joshua; Musubire, Abdu K; Tugume, Lillian; Nuwagira, Edwin; Abassi, Mahsa; Ssebambulidde, Kenneth; Mpoza, Edward; Kiggundu, Ruben; Akampurira, Andrew; Nabeta, Henry W; Schutz, Charlotte; Evans, Emily E; Rajasingham, Radha; Skipper, Caleb P; Pastick, Katelyn A; Williams, Darlisha A; Morawski, Bozena M; Bangdiwala, Ananta S; Meintjes, Graeme; Muzoora, Conrad; Meya, David B; Boulware, David R (Clinical Infectious Diseases, 2020)
      Background: In cryptococcal meningitis phase 2 clinical trials, early fungicidal activity (EFA) of Cryptococcus clearance from cerebrospinal fluid (CSF) is used as a surrogate endpoint for all-cause mortality. The Food and ...

    • Cerebrospinal Fluid Lactate as a Prognostic Marker of Disease Severity and Mortality in Cryptococcal Meningitis 

      Abassi, Mahsa; Bangdiwala, Ananta S.; Nuwagira, Edwin; Tadeo, Kiiza Kandole; Okirwoth, Michael; Williams, Darlisha A.; Mpoza, Edward; Tugume, Lillian; Ssebambulidde, Kenneth; Hullsiek, Kathy Huppler; Musubire, Abdu K.; Muzoora, Conrad; Rhein, Joshua; Meya, David B.; Boulware, David R. (Clinical Infectious Diseases, 2021)
      Background: Cerebrospinal fluid (CSF) lactate levels can be used to differentiate between bacterial and viral meningitis. We measured CSF lactate in individuals with cryptococcal meningitis to determine its clinical ...

    • Detrimental Outcomes of Unmasking Cryptococcal Meningitis With Recent ART Initiation 

      Rhein, Joshua; Hullsiek, Kathy H.; Evans, Emily E.; Tugume, Lillian; Nuwagira, Edwin; Ssebambulidde, Kenneth; Kiggundu, Reuben; Mpoza, Edward; Musubire, Abdu K.; Bangdiwala, Ananta S.; Bahr, Nathan C.; Williams, Darlisha A.; Abassi, Mahsa; Muzoora, Conrad; Meya, David B.; Boulware, David R. (In Open forum infectious diseases, 2018)
      Background: Increased antiretroviral therapy (ART) availability has been associated with more patients developing cryptococcosis after ART initiation. Despite this changing epidemiology, data regarding cryptococcal meningitis ...

    • The effect of sertraline on depression and associations with persistent depression in survivors of HIV-related cryptococcal meningitis 

      Lofgren, Sarah M.; Velamakanni, Sruti S.; Hullsiek, Katherine Huppler; Bangdiwala, Ananta S.; Namudde, Alice; Musubire, Abdu K.; Mpoza, Edward; Abassi, Mahsa; . Pastick, Katelyn A; Nuwagira, Edwin; Evans, Emily E.; Rajsasingham, Radha; . Williams, Darlisha A; Muzoora, Conrad; Creswell, Fiona V.; Rhein, Joshua; Bond, David J.; Nakasujja, Noeline; Meya, David B.; Boulware, David R. (Wellcome Open Research, 2021)
      Background: Depression is a risk factor for worse outcomes in persons living with HIV/AIDS and has a prevalence more than three times as high as in the general population. Despite this, there are few randomized studies of ...

    • Evaluation of a point-of-care immunoassay test kit `StrongStep' for cryptococcal antigen detection 

      Mpoza, Edward; Mukaremera, Liliane; Kundura, Didas Atwebembere; Akampurira, Andrew; Luggya, Tonny; Tadeo, Kiiza Kandole; Pastick, Katelyn A.; Bridge, Sarah C.; Tugume, Lillian; Kiggundu, Reuben; Musubire, Abdu K.; Williams, Darlisha A.; Muzoora, Conrad; Nalintya, Elizabeth; Rajasingham, Radha; Rhein, Joshua; Boulware, David R.; Meya, David B.; Abassi, Mahsa (PLoS One, 2018)
      Background: HIV-associated cryptococcal meningitis is the leading cause of adult meningitis in Sub- Saharan Africa, accounting for 15%±20% of AIDS-attributable mortality. The development of point-of-care assays has greatly ...

    • High Mortality Associated with Unmasking Cryptococcal Meningitis 

      Rhein, Joshua; Hullsiek, Kathy Huppler; Bahr, Nathan C; Tugume, Lillian; Nuwagira, Edwin; Ssebambulidde, Kenneth; Kiggundu, Reuben; Evans, Emily E; Mpoza, Edward; Williams, Darlisha A; Abassi, Mahsa; Musubire, Abdu; Muzoora, Conrad; Meya, David B; Boulware, David R (Boston, 2018)
      Introduction: Increased antiretroviral therapy (ART) availability in Africa has led to more patients developing cryptococcosis after ART initiation. Despite this changing epidemiology, data regarding cryptococcal meningitis ...

    • HIV-Associated Cryptococcal Meningitis Occurring at Relatively Higher CD4 Counts 

      Tugume, Lillian; Rhein, Joshua; Hullsiek, Kathy Huppler; Mpoza, Edward; Kiggundu, Reuben; Ssebambulidde, Kenneth; Schutz, Charlotte; Taseera, Kabanda; Williams, Darlisha A.; Abassi, Mahsa; Muzoora, Conrad; Musubire, Abdu K.; Meintjes, Graeme; Meya, David B.; Boulware, David R.; On behalf of COAT and ASTRO-CM teams (The Journal of infectious diseases, 2019)
      Background: Cryptococcal meningitis can occur in persons with less-apparent immunosuppression. We evaluated clinical characteristics and outcomes of persons with HIV-related Cryptococcus presenting with higher CD4 ...

    • Mid–Upper Arm Circumference Is a Strong Predictor of Mortality Among Ugandan Adults With HIV-Associated Cryptococcal Meningitis: A Prospective Cohort Study 

      Hale, Gila; Adzemovic, Tessa; Hullsiek, Kathy Huppler; Mulwana, Suzan; Ndyetukira, Jane Francis; Sadiq, Alisat; Kabahubya, Mable; Ayebare, Peruth; Nankungu, Lydia; Namudde, Alice; Namanda, Sylvia; Menya, Grace; Nakitto, Grace; Muzoora, Conrad; Nuwagira, Edwin; Rhein, Joshua; Meya, David B.; Boulware, David R.; Ellis, Jayne; Abassi, Mahsa (Open Forum Infectious Diseases, 2024)
      Background: Mortality among adults diagnosed with HIV-associated cryptococcal meningitis remains high (24%–40%). We hypothesized that nutritional state, as measured by mid–upper arm circumference (MUAC), is a potentially ...

    • Oral Lipid Nanocrystal Amphotericin B for Cryptococcal Meningitis: A Randomized Clinical Trial 

      Boulware, David R.; Atukunda, Mucunguzi; Kagimu, Enock; Musubire, Abdu K.; Akampurira, Andrew; Tugume, Lillian; Ssebambulidde, Kenneth; Kasibante, John; Nsangi, Laura; Mugabi, Timothy; Gakuru, Jane; Kimuda, Sarah; Kasozi, Derrick; Namombwe, Suzan; Turyasingura, Isaac; Rutakingirwa, Morris K.; Mpoza, Edward; Kigozi, Enos; Muzoora, Conrad; Ellis, Jayne; Skipper, Caleb P.; Matkovits, Theresa; Williamson, Peter R.; Williams, Darlisha A.; Fieberg, Ann; Hullsiek, Kathy H.; Abassi, Mahsa; Dai, Biyue; Meya, David B. (Clinical Infectious Diseases, 2023)
      Background: Amphotericin B is the gold standard treatment for severe mycoses. A new orally delivered, less-toxic formulation of amphotericin has been developed. Methods: In our randomized clinical trial, we tested oral ...

    • Outpatient Cryptococcal Antigen Screening Is Associated With Favorable Baseline Characteristics and Improved Survival in Persons With Cryptococcal Meningitis in Uganda 

      Levin, Anna E.; Bangdiwala, Ananta S.; Nalintya, Elizabeth; Kagimu, Enock; Kasibante, John; Rutakingirwa, Morris K.; Mpoza, Edward; Jjunju, Samuel; Nuwagira, Edwin; Naluyima, Rose; Kirumira, Paul; Hou, Cody; Ssebambulidde, Kenneth; Musubire, Abdu K.; Williams, Darlisha A.; Abassi, Mahsa; Muzoora, Conrad; Hullsiek, Katherine H.; Rajasingham, Radha; Meya, David B.; Boulware, David R.; Skipper, Caleb P. (Clinical Infectious Diseases, 2023)
      Background: It is unknown whether persons with symptomatic cryptococcal meningitis detected during routine blood cryptococcal antigen (CrAg) screening have better survival than persons presenting with overt meningitis. ...

    • A secondary analysis of depression outcomes from a randomized controlled trial of adjunctive sertraline for HIV associated cryptococcal meningitis 

      Lofgren, Sarah M.; Velamakanni, Sruti S.; Hullsiek, Katherine Huppler; Bangdiwala, Ananta S.; Namudde, Alice; Musubire, Abdu K.; Mpoza, Edward; Abassi, Mahsa; Pastick, Katelyn A.; Nuwagira, Edwin; Evans, Emily E.; Rajsasingham, Radha; Williams, Darlisha A.; Muzoora, Conrad; Creswell, Fiona V.; Rhein, Joshua; Bond, David J.; Nakasujja, Noeline; Meya, David B.; Boulware, David R. (Wellcome Open Research, 2022)
      Background: Depression is a risk factor for worse HIV outcomes in persons living with HIV/AIDS, including engagement-in-care, HIV medication adherence, and retention-in-care. Depression has a prevalence of more than three ...

    • Symptomatic Cryptococcal Antigenemia Presenting as Early Cryptococcal Meningitis With Negative Cerebral Spinal Fluid Analysis 

      Ssebambulidde, Kenneth; Bangdiwala, Ananta S.; Kwizera, Richard; Kandole, Tadeo Kiiza; Tugume, Lillian; Kiggundu, Reuben; Mpoza, Edward; Nuwagira, Edwin; Williams, Darlisha A.; Lofgren, Sarah M.; Abassi, Mahsa; Musubire, Abdu K.; Cresswell, Fiona V.; Rhein, Joshua; Muzoora, Conrad; Hullsiek, Kathy Huppler; Boulware, David R.; Meya, David B. (Clinical Infectious Diseases, 2019)
      Background: Individuals with cryptococcal antigenemia are at high risk of developing cryptococcal meningitis if untreated. The progression and timing from asymptomatic infection to cryptococcal meningitis is unclear. We ...

    • Therapeutic lumbar punctures in HIV-associated cryptococcal meningitis: should opening 3 pressure direct management 

      Kagimu, Enock; Engen, Nicole; Ssebambulidde, Kenneth; Kasibante, John; Kiiza, Tadeo K; Mpoza, Edward; L, Lillian Tugume; Nuwagira, Edwin; Nsangi, Laura; Williams, Darlisha A; Hullsiek, Kathy Huppler; Boulware, David R; Meya, David B; Rhein, Joshua; Abassi, Mahsa; Musubire, Abdu K (In Open Forum Infectious Diseases, 2022)
      Background: Increased intracranial pressure (ICP) frequently complicates cryptococcal meningitis. Therapeutic lumbar punctures (LPs) have acute survival benefits in the first week, 4and we sought to understand the longer-term ...