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  Diagnostic Prediction Model for Tuberculous Meningitis: An Individual Participant Data Meta-Analysis 

  Stadelman-Behar, Anna M.; Tiffin, Nicki; Ellis, Jayne; Creswell, Fiona V.; Ssebambulidde, Kenneth; Nuwagira, Edwin; Richards, Lauren; Lutje, Vittoria; Hristea, Adriana; et al (The American Journal of Tropical Medicine and Hygiene, 2024)

  No accurate and rapid diagnostic test exists for tuberculous meningitis (TBM), leading to delayed diagnosis. We leveraged data from multiple studies to improve the predictive performance of diagnostic models across different ...
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  Population Effectiveness of Dolutegravir Implementation in Uganda: A Prospective Observational Cohort Study (DISCO), 48-Week Results 

  McCluskey, Suzanne M.; Muyindike, Winnie R.; Nanfuka, Victoria; Omoding, Daniel; Komukama, Nimusiima; Barigye, Ian T.; Kansiime, Lydia; Tumusiime, Justus; Aung, Taing N.; Stuckwisch, Ashley; Hedt-Gauthier, Bethany; Marconi, Vincent C.; Moosa, Mahomed-Yunus S.; Pillay, Deenan; Giandhari, Jennifer; Lessells, Richard; Gupta, Ravindra K.; Siedner, Mark J. (The Journal of Infectious Diseases, 2024)

  Background: Tenofovir/lamivudine/dolutegravir (TLD) is the preferred first-line antiretroviral therapy (ART) regimen for people with HIV (PWH), including those who were previously virologically suppressed on nonnucleoside ...
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  Mid–Upper Arm Circumference Is a Strong Predictor of Mortality Among Ugandan Adults With HIV-Associated Cryptococcal Meningitis: A Prospective Cohort Study 

  Hale, Gila; Adzemovic, Tessa; Hullsiek, Kathy Huppler; Mulwana, Suzan; Ndyetukira, Jane Francis; Sadiq, Alisat; Kabahubya, Mable; Ayebare, Peruth; Nankungu, Lydia; Namudde, Alice; Namanda, Sylvia; Menya, Grace; Nakitto, Grace; Muzoora, Conrad; Nuwagira, Edwin; Rhein, Joshua; Meya, David B.; Boulware, David R.; Ellis, Jayne; Abassi, Mahsa (Open Forum Infectious Diseases, 2024)

  Background: Mortality among adults diagnosed with HIV-associated cryptococcal meningitis remains high (24%–40%). We hypothesized that nutritional state, as measured by mid–upper arm circumference (MUAC), is a potentially ...
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  Death after cure: Mortality among pulmonary tuberculosis survivors in rural Uganda 

  Baluku, Joseph Baruch; Namanda, Brenda; Namiiro, Sharon; Rwabwera, Diana Karungi; Mwesigwa, Gloria; Namaara, Catherine; Twinomugisha, Bright; Nyirazihawe, Isabella; Nuwagira, Edwin; Kansiime, Grace; Kizito, Enock; Nabukenya-Mudiope, Mary G.; Sekadde, Moorine Penninah; Bongomin, Felix; Senfuka, Joshua; Olum, Ronald; Byaruhanga, Aggrey; Munabi, Ian; Kiguli, Sarah (International Journal of Infectious Diseases, 2024)

  Objectives: To determine the incidence of mortality and its predictors among pulmonary tuberculosis (PTB) survivors treated at a rural Ugandan tertiary hospital. Methods: We conducted a retrospective chart review of data ...
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  How Does Antiretroviral Treatment Attenuate the Stigma of HIV? Evidence from a Cohort Study in Rural Uganda 

  Tsai, Alexander C.; . Bangsberg, David R; Bwana, Mwebesa; Haberer, Jessica E.; Frongillo, Edward A.; Muzoora, Conrad; Kumbakumba, Elias; Hunt, Peter W.; Martin, Jeffrey N.; Weiser, Sheri D. (AIDS and Behavior, 2013)

  Program implementers and qualitative researchers have described how increasing availability of HIV antiretroviral therapy (ART) is associated with improvements in psychosocial health and internalized stigma. To determine ...
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  Endoscopically diagnosed hookworm infestation in an adult with chronic iron infestation in an adult with chronic iron deficiency anaemia 

  Abdirahman, Mohamed Mukhtar; Baruhanga, Emmanuel; Muhumuza, Andrew; Wagubi, Robert; Atwine, Raymond; Tumuhimbise, Christine; Tusiime, Florence; Tuhumwire, Caleb; Lumori, Boniface Amanee Elias (South Sudan Medical Journal, 2024)

  Despite advances in hookworm control and prevention campaigns, the prevalence remains high in sub-Saharan Africa. Iron deficiency anaemia is a major complication in those with prolonged infection, a high hookworm burden, ...
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  Oral Lipid Nanocrystal Amphotericin B for Cryptococcal Meningitis: A Randomized Clinical Trial 

  Boulware, David R.; Atukunda, Mucunguzi; Kagimu, Enock; Musubire, Abdu K.; Akampurira, Andrew; Tugume, Lillian; Ssebambulidde, Kenneth; Kasibante, John; Nsangi, Laura; Mugabi, Timothy; Gakuru, Jane; Kimuda, Sarah; Kasozi, Derrick; Namombwe, Suzan; Turyasingura, Isaac; Rutakingirwa, Morris K.; Mpoza, Edward; Kigozi, Enos; Muzoora, Conrad; Ellis, Jayne; Skipper, Caleb P.; Matkovits, Theresa; Williamson, Peter R.; Williams, Darlisha A.; Fieberg, Ann; Hullsiek, Kathy H.; Abassi, Mahsa; Dai, Biyue; Meya, David B. (Clinical Infectious Diseases, 2023)

  Background: Amphotericin B is the gold standard treatment for severe mycoses. A new orally delivered, less-toxic formulation of amphotericin has been developed. Methods: In our randomized clinical trial, we tested oral ...
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  Implementation of a safer conception programme for HIV- affected men and women in rural Uganda 

  Matthews, Lynn T.; Owembabazi, Moran; Tukwasibwe, Deogratius; Najjuma, Alice; Muyindike, Winnie; Tumwine, John Mary; Hornstein, Benjamin; Bassler, John; Long, Dustin; Gill, Elizabeth; Young, Cynthia; Chitneni, Pooja; Psaros, Christina; Kanyesigye, Micheal; Kalyebara, Paul Kato; Kaida, Angela; Bwana, Mwebesa (Global Public Health, 2024)

  We integrated safer conception care into a Ugandan HIV clinic. People with HIV (PWH), or partnered with a PWH, and desiring children were eligible for the Healthy Families Clinic Program. Clients completed quarterly safer ...
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  Diagnostic performance of fecal Helicobacter pylori antigen test in Uganda 

  Owot, Jacob Canwat; Tuhumwire, Caleb; Tumuhimbise, Christine; Tusiime, Florence; Emmanuel, Byaruhanga; Lumori, Boniface A. E.; Okello, Samson (BMC gastroenterology, 2022)

  We evaluated the diagnostic performance of a qualitative stool antigen test (SAT) in individuals with dyspepsia in rural Uganda using the polymerase chain reaction-based 16S ribosomal RNA assay (16S rRNA) for nucleotide ...
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  Association between biomarkers of inflammation and dyslipidemia in drug resistant tuberculosis in Uganda 

  Baluku, Joseph Baruch ; Nalwanga, Robinah ; Kazibwe, Andrew ;  Olum, Ronald; Nuwagira, Edwin ;  Mugenyi, Nathan; Mulindwa, Frank ;  Bongomin, Felix (Lipids in Health and Disease, 2024)

  Background: Active tuberculosis (TB) significantly increases the risk of cardiovascular disease, but the underlying mechanisms remain unclear. This study aimed to investigate the association between inflammation biomarkers ...
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  Cryptococcal Meningitis and Clinical Outcomes in Persons With Human Immunodeficiency Virus: A Global Vie 

  Person, Anna K.; Crabtree-Ramirez, Brenda; Kim, Ahra; Veloso, Valdiléa; Maruri, Fernanda; Wandeler, Gilles; Fox, Matthew; Moore, Richard; Gill, M. John; Imran, Darma; Nguyen, Kinh Van; Nalitya, Elizabeth; Muyindike, Winnie; Shepherd, Bryan E.; McGowan, Catherine C. (Clinical Infectious Diseases, 2023)

  Background: Cryptococcal meningitis (CM) is a major cause of morbidity and mortality in persons with human immunodeficiency virus (HIV; PWH). Little is known about CM outcomes and availability of diagnostic and treatment ...
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  Participant perspectives on incentives for TB preventative therapy adherence and reduced alcohol use: A qualitative study 

  Appa, Ayesha; Miller, Amanda P.; Fatch, Robin; Kekibiina, Allen; Beesiga, Brian; Adong, Julian; Emenyonu, Nneka; Marson, Kara; Getahun, Monica; Kamya, Moses; Muyindike, Winnie; McDonell, Michael; Thirumurthy, Harsha; Hahn, Judith A.; Chamie, Gabriel; Camlin, Carol S. (PLOS Global Public Health, 2024)

  Economic incentives to promote health behavior change are highly efficacious for substance use disorders as well as increased medication adherence. Knowledge about participants’ experiences with and perceptions of incentives ...
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  Alcohol Consumption in Ugandan HIV-Infected Household-Brewers Versus Non-Brewers 

  Thakarar, Kinna; Asiimwe, Stephen B.; Cheng, Debbie M.; Forman, Leah; Ngabirano, Christine; Muyindike, Winnie R.; Emenyonu, Nneka I.; Samet, Jeffrey H.; Hahn, Judith A. (AIDS and Behavior, 2016)

  The brewing of alcohol in Ugandan households is common, yet little is known about its relationship with alcohol consumption in HIV-infected individuals. We performed a cross-sectional analysis to assess the association ...
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  Alcohol Use and Food Insecurity Among People Living with HIV in Mbarara, Uganda and St. Petersburg, Russia 

  Patts, Gregory J.; Cheng, Debbie M.; Emenyonu, Nneka; Bridden, Carly; Gnatienko, Natalia; Lloyd-Travaglini, Christine A.; Ngabirano, Christine; Yaroslavtseva, Tatiana; Muyindike, Winnie R.; Weiser, Sheri D.; Krupitsky, Evgeny M.; Hahn, Judith A.; Samet, Jeffrey H. (AIDS and Behavior, 2017)

  Food insecurity (FI) is a documented problem associated with adverse health outcomes among HIV-infected populations. Little is known about the relationship between alcohol use and FI. We assessed whether heavy alcohol use ...
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  Agreement Between Measures of Adherence to Isoniazid Preventive Therapy Among People With HIV in Uganda 

  Forman, Leah S.; Lodi, Sara; Fatch, Robin; Emenyonu, Nneka I.; Adong, Julian; Ngabirano, Christine; Jacobson, Karen R.; Gerona, Roy; Reckers, Andrew R.; Gandhi, Monica; Muyindike, Winnie R.; Hahn, Judith A. (In Open forum infectious diseases, 2022)

  Background: Isoniazid (INH) preventative therapy is recommended for people with HIV (PWH) in resource-constrained settings. Valid measures are needed to assess adherence. We aimed to examine agreement between measures ...
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  Social Desirability Bias Impacts Self-Reported Alcohol Use Among Persons With HIV in Uganda 

  Adong, Julian; Fatch, Robin; Emenyonu, Nneka I.; Cheng, Debbie M.; Muyindike, Winnie R.; Ngabirano, Christine; Kekibiina, Allen; Woolf-King, Sarah E.; Samet, Jeffrey H.; Hahn, Judith A. (Alcoholism: Clinical and Experimental Research, 2019)

  Background: Self-report is widely used to assess alcohol use in research and clinical practice, but may be subject to social desirability bias. We aimed to determine if social desirability impacts self-reported alcohol ...
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  Unhealthy Alcohol Use Is Associated With Suboptimal Adherence to Isoniazid Preventive Therapy in Persons With HIV in Southwestern Ugand 

  Muyindike, Winnie R.; Fatch, Robin; Cheng, Debbie M.; Emenyonu, Nneka I.; Forman, Leah; Ngabirano, Christine; Adong, Julian; Linas, Benjamin; Jacobson, Karen R.; Hahn, Judith A. (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2022)

  Background: Unhealthy alcohol use is associated with increased progression to tuberculosis (TB) disease, but its effect on adherence to isoniazid (INH) preventive therapy is not known. Methods: This was a prospective ...
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  Unhealthy Alcohol Use is Associated with Monocyte Activation Prior to Starting Antiretroviral Therapy 

  Carrico, Adam W.; Hunt, Peter W.; Emenyonu, Nneka I.; Muyindike, Winnie; Ngabirano, Christine; Cheng, Debbie M.; Winter, Michael R.; Samet, Jeffrey H.; Hahn, Judith A. (Clinical and Experimental Research, 2015)

  Background: Alcohol use may accelerate HIV disease progression, but the plausible biological mechanisms have not been clearly elucidated. Methods: HIV-positive persons who were not on antiretroviral therapy (ART) completed ...
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  Alcohol Use and HIV Disease Progression in an Antiretroviral Naive Cohort 

  Hahn, Judith A.; Cheng, Debbie M.; Emenyonu, Nneka I.; Lloyd-Travaglini, Christine; Fatch, Robin; Shade, Starley B.; Ngabirano, Christine; Adong, Julian; Bryant, Kendall; Muyindike, Winnie R.; Samet, Jeffrey H. (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2018)

  Background: Alcohol use has been shown to accelerate disease progression in experimental studies of simian immunodeficiency virus in macaques, but the results in observational studies of HIV have been conflicting. Methods: ...
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  Alcohol Consumption and Tryptophan Metabolism Among People with HIV Prior to Antiretroviral Therapy Initiation: The Uganda ARCH Cohort Study 

  Pierre, Frantz; Forman, Leah S.; Winter, Michael; Cheng, Debbie; Ngabirano, Christine; Emenyonu, Nneka; Hunt, Peter W.; Huang, Yong; Muyindike, Winnie; Samet, Jeffrey; Hahn, Judith A.; So-Armah, Kaku (Alcohol and Alcoholism, 2022)

  Aims: Alcohol is hypothesized to have effects on the kynurenine pathway of tryptophan catabolism, a potential mechanism for alcohol-induced depression and aggression. A biomarker of this pathway, the plasma kynurenine to ...

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