Department of Biochemistry
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Recent Submissions
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High Silent Prevalence of Zinc Deficiency and Impaired Immunity in Children Under Five Years of Age Admitted to a Regional Referral Hospital in Uganda
(Cureus, 2024)Introduction: Zinc deficiency (ZnD) impairs the development of acquired immunity and contributes to growth failure in children under five years of age. However, the prevalence of ZnD and its association with immunity in ... -
Role of microRNAs in skin aging and its potential therapeutic interventions
(Aging Pathobiology and Therapeutics, 2024)The skin, the largest and most important organ of the body, serves diverse functions such as protection from the outside, temperature regulation, etc. It is composed of 3 layers: hypodermis, dermis, and epidermis. As the ... -
Point-of-care potentials of lateral flow-based field screening for Mycoplasma bovis infections: a literature review
(Biology Methods and Protocols, 2024)Point-of-care (POC) field screening for tools for Mycoplasma bovis (M. bovis) is still lacking due to the requirement for a simple, robust field-applicable test that does not entail specialized laboratory equipment. In ... -
In‑vivo and in‑silico studies revealed the molecular mechanisms of Colocasia esculenta phenolics as novel chemotherapy against benign prostatic hyperplasia via inhibition of 5α‑reductase and α1‑adrenoceptor
(In Silico Pharmacology, 2023)Benign Prostatic Hyperplasia (BPH) is a major cause of lower urinary tract infections and erectile dysfunction thus a major contributor to lowering the quality of life among older men. In this study, we investigated the ... -
Safety profile of colocasia esculenta tuber extracts in benign prostate hyperplasia
(BMC complementary medicine and therapies, 2023)Introduction: This study was motivated by the increasing global incidence of benign prostatic hyperplasia (BPH) and the promising potential of nutraceuticals as complementary therapies in ameliorating its burden. We report ... -
Iron status of pregnant women at first antenatal booking in Mbarara University Teaching Hospital
(Tropical doctor, 1999)An assessment of iron status was made on 96 pregnant women and 29 non-pregnant, non-lactating menstruat- ing women of comparable age group as controls. Anaemia (haemoglobin < 110 g/l) was present in 84.4% of the pregnant ... -
Genetic diversity in Plasmodium falciparum merozoite surface protein 1 and 2 coding genes and its implications in malaria epidemiology: a review of published studies from 1997–2007
(Journal of Vector Borne Diseases, 2009-04)A major characteristic of human malaria parasites is their genetic diversity and an increasing number of studies have been reported on the epidemiology of Plasmodium falciparum, mainly focusing on the polymorphism of ... -
CD4-T-Lymphocyte Reference Ranges in Uganda and Its Influencing Factors
(Laboratory Medicine, 2011)Background: Given the importance of CD4-T-lymphocyte monitoring in HIV/ART management, we established CD4/CD8 reference ranges in Uganda and studied factors associated with CD4/CD8 in a normal population. Methods: Blood ... -
Cucumeropsis mannii seed oil protects against bisphenol A-induced hepatotoxicity by mitigating inflammation and oxidative stress in rats
(RPS Pharmacy and Pharmacology Reports, 2024)Objectives: This study looked at how Cucumeropsis mannii seed oil (CMSO) affected male Wistar albino rats’ liver damage caused by bisphenol A (BPA). Methods: The standard HPLC method was used to assess the CMSO’s ... -
Bioremedial potential of bacteria isolated from soil in automobile garages and fuel stations in Mbarara City, Southwestern Uganda
(Bioremediation Journal, 2024)The use of bacteria to clean up oil-contaminated soils is widely considered the most desirable bioremediation strategy. The majority of research has focused on contaminated soils in large oil-producing countries. However, ... -
Misinformation, knowledge and COVID-19 vaccine acceptance: a cross-sectional study among health care workers and the general population in Kampala, Uganda
(BMC Public Health, 2024)COVID-19 has greatly affected communities worldwide, more so in low- and middle-income countries. To successfully resolve the COVID-19 pandemic, vaccination coverage of more than 80% is required. However, misinformation ... -
Elucidation of chemical profiles and molecular targets of Mondia whitei leave fractions bioactive as novel therapeutics: an in vitro and in silico assay
(Journal of Genetic Engineering and Biotechnology, 2022)Background: Mondia whitei root is often used in Africa as a local therapeutic agent for libido enhancement. The fractions of the M. whitei leaves (MWL) lack chemical characterization of their bioactive components and ... -
MicroRNA-510-3p and Its Gene Network in the Disease Regulation of Preeclampsia: An Insilico Approach
(Journal of Biological Regulators and Homeostatic Agents, 2023)Background: Preeclampsia (PE) is a major health complication for pregnant women that increases the risk of mortality and morbidity. Knowledge of the complex molecular mechanisms associated with PE is incomplete and methods ... -
TDP-43 and NEAT long non-coding RNA: Roles in neurodegenerative disease
(Frontiers in Cellular Neuroscience, 2022)Understanding and ameliorating neurodegenerative diseases represents a key challenge for supporting the health span of the aging population. Diverse protein aggregates have been implicated in such neurodegenerative disorders, ... -
Corrigendum: TDP-43 and NEAT long non-coding RNA: Roles in neurodegenerative disease
(Frontiers in Cellular Neuroscience, 2022)“Understanding and ameliorating neurodegenerative diseases represents a key challenge for supporting the health span of the aging population. Diverse protein aggregates have been implicated in such neurodegenerative ... -
UCP-LF and other assay methods for schistosome circulating anodic antigen between 1978 and 2022
(Biology Methods and Protocol, 2023)Detection of circulating anodic antigen (CAA) is known for its high sensitivity in diagnosing schistosomiasis infection, even in low-prevalence settings. The Up-Converting Phosphor-Lateral Flow (UCP-LF) assay developed in ... -
Comparison of the Nutritional Status of Swiss Albino Mice Fed on Either a Purified or Cereal-Based Diet for 15 weeks
(Biochemistry Research International, 2023)Background: Laboratory animals are commonly fed on cereal-based diets (CBDs) whose nutrient composition is unknown and may confound the metabolic response to study interventions. Puri2ed diets such as AIN-93M are therefore ... -
Combating Lassa Fever in West African Sub-Region: Progress, Challenges, and Future Perspectives
(Viruses, 2023)Lassa fever (LF) is a rodent-borne disease that threatens human health in the sub-region of West Africa where the zoonotic host of Lassa virus (LASV) is predominant. Currently, treatment options for LF are limited and since ... -
Cucumeropsis mannii seed oil ameliorates Bisphenol-A- induced adipokines dysfunctions and dyslipidemia
(Food Science & Nutrition, 2023)This study demonstrated the therapeutic potentials of Cucumeropsis mannii seed oil (CMSO) capable of alleviating BPA-induced dyslipidemia and adipokine dysfunction. In this study, we evaluated the effects of CMSO on adipokine ... -
Effect of Extraction Period on Total Phenolics, Total Flavonoids, and Antioxidant Capacity of Ugandan Camellia sinensis (L) Kuntze, Black Primary Grades and Green Tea
(Journal of Food Quality, 2023)Introduction: Globally, the consumption and production of tea are on the rise because of its beneficial constituents. Scarce literature exists on the e1ects of extraction periods on the contents of the biologically important ...
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