Cucumeropsis mannii seed oil protects against bisphenol A-induced hepatotoxicity by mitigating inflammation and oxidative stress in rats
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Date
2024Author
Aja, Patrick Maduabuchi
Chukwu, Chinecherem Adanna
Ugwu, Okechukwu Paul-Chima
Ale, Boniface Anthony
Agu, Peter Chinedu
Deusdedi, Tusubira
Chukwu, Darlington C.
l Ani, Onyedika Gabrie
Ekpono, Ezebuilo Ugbala
Ogwoni, Hilary Akobi
Awoke, Joshua Nonso
Ogbu, Patience N.
Aja, Lucy
Ukachi, Oliver Ugochukwu
Orji, Obasi Uche
Nweke, Chinoso Peter
Egwu, Chinedu
Ekpono, Ejike Ugbala
Ewa, Gift Onyinyechi
et al
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Objectives: This study looked at how Cucumeropsis mannii seed oil (CMSO) affected male Wistar albino rats’ liver damage caused by bisphenol A (BPA).
Methods: The standard HPLC method was used to assess the CMSO’s phenolic content. Then, six (n = 8) groups of 48 male Wistar rats (150 20 g) each received either CMSO or olive oil before being exposed to BPA for 42 days. Groups: A (1 ml of olive oil, regardless of weight), B (BPA 100 mg/kg body weight (BW)), C (CMSO 7.5 mg/kg BW), D (CMSO 7.5 mg/kg BW + BPA 100 mg/kg BW), E (CMSO 5.0 mg/kg BW + BPA 100 mg/kg BW), and F (CMSO 2.5 mg/kg BW + BPA 100 mg/kg BW).
Key findings: A surprising abundance of flavonoids, totalling 17.8006 10.95 g/100 g, were found in the HPLC data. Malondialdehyde, liver enzymes, reactive oxygen species, total bilirubin, and direct bilirubin levels were all significantly elevated by BPA (P = 0.05). Additionally, nuclear Factor-B, interleukin-6, interleukin-1, tumour necrosis factor, and histological alterations were all considerably (P = 0.05) caused by BPA. The altered biochemical markers and histology were, however, noticeably recovered by CMSO to a level that was comparable to the control. Conclusions: Due to the abundance of flavonoid components in the oil, CMSO protects the liver from BPA-induced hepatotoxicity by lowering oxidative stress and inflammatory reactions
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