• Environmental DNA barcoding reveals general biodiversity patterns in the large tropical rift Lake Albert 

  Balint, Miklos; Tumusiime, Julius; Nakintu, Justine; Baranski, Damian; Schardt, Leonie; Romahn, Juliane; Dusabe, Marie-Claire; Tolo, Casim Umba; Kagoro, Grace Rugunda; Ssenkuba, Francis; Junginger, Annett; Albrecht, Christian (Science of the Total Environment, 2024)

  Lake Albert, Africa’s seventh-largest lake and a biodiversity hotspot, faces significant environmental challenges, including unregulated anthropogenic pressure and a lack of comprehensive biological studies. To address the ...
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  Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use 

  Keenan, Katherine; Papathomas, Michail; Mshana, Stephen E.; Asiimwe, Benon; Kiiru, John; Lynch, AndyG.; Kesby, Mike; Neema, Stella; Mwanga, Joseph R.; Mushi, Martha F.; Jing, Wei; Green, Dominique L.; Olamijuwon, Emmanuel; Zhang, Qing; Sippy, Rachel; Fredricks, Kathryn J.; Gillespie, Stephen H.; Sabiiti, Wilber; Bazira, Joel; Sloan, Derek J.; Mmbaga, Blandina T.; Kibiki, Gibson; Aanensen, David; Stelling, John; Smith, V. Anne; Sandeman, Alison; Holden, Matthew T. G.; HATUA Consortium (Nature Communications, 2024)

  The global health crisis of antibacterial resistance (ABR) poses a particular threat in low-resource settings like East Africa. Interventions for ABR typically target antibiotic use, overlooking the wider set of factors ...
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  Exploring healthcare professionals’ perspectives on neglected tropical diseases in Eastern Uganda a qualitative study with a focus on schistosomiasis and soil-transmitted helminths 

  Kihumuro, Raymond Bernard; Atimango, Lorna; Kintu, Timothy Mwanje; Makai, Conrad; Kanyike, Andrew Marvin; Bazira, Joel (Transactions of The Royal Society of Tropical Medicine and Hygiene, 2024)

  Background: Neglected tropical diseases (NTDs), including soil-transmitted helminths (STHs) and schistosomia sis, continue to impose a heavy burden, especially ...
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  Organ donation and HIV: Awareness and willingness to be a living donor among people with HIV in Uganda 

  Bongomin, Felix; Nantale, Ritah; Kibone, Winnie; Awekonimungu, Byron; Oyoo, Nixson; Okello, James; Muzoora, Conrad; Hamer, Davidson H. (Transplant Infectious Disease, 2024)

  Background: HIV+-to-HIV+ organ transplantation has demonstrated promise and is now authorized for research purposes in certain countries. However, organ transplantation is dependent on the availability of organ donors. We ...
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  Effects of Alcohol Use on Patient Retention in HIV Care in East Africa 

  Monroy, Alexa ; Goodrich, Suzanne ;  Brown, Steven A.; Balanos, Theofanis ;  Bakoyannis, Giorgos; Diero, Lameck ;  Byakwaga, Helen; Muyindike, Winnie ;  Kanyesigye, Michael; Aluda, Maurice ;  Lewis‑Kulzer, Jayne; Yiannoutsos, Constantin ;  Wools‑Kaloustian, Kara; On behalf of The East Africa International Epidemiologic Databases to Evaluate AIDS (EA‑IeDEA) Consortium (AIDS and Behavior, 2024)

  We sought to investigate the association between hazardous alcohol use and gaps in care for people living with HIV over a long-term follow-up period. Adults who had participated in our previously published Phase I study ...
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  Self-Rated Competence of Ugandan Healthcare Workers to Obtain Informed Consent for Autopsy 

  Bongomin, Felix; Kibone, Winnie; Nantale, Ritah; Lukande, Robert; Bromley, Ruth; Muzoora, Conrad; Hamer, Davidson H. (The American journal of tropical medicine and hygiene, 2024)

  We examined the self-rated competence of Ugandan healthcare workers (HCWs) in obtaining informed consent for autopsies, considering the challenges of low autopsy acceptance rates globally. In September and October 2023, ...
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  Point-of-care urine tenofovir testing to predict HIV drug resistance among individuals with virologic failure 

  Mccluskey, Suzanne M.; Govender, Katya; Adamson, John; Gandhi, Monica; Spinelli, Matthew A.; Moosa, Mahomed-Yunus; Muyindike, Winnie; Moodley, Pravi; Pillay, Melendhran; Masette, Godfrey; Sunpath, Henry; Pillay, Selvan; Chen, Geoffrey; Hedt-Gauthier, Bethany; Marconi, Vincent C.; Siedner, Mark J. (AIDS, 2023)

  Objective: We sought to evaluate the utility of a point-of-care (POC) urine tenofovir (TFV) assay, developed to objectively assess adherence, to predict HIV drug resistance (HIVDR) in people failing first-line antiretroviral ...
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  Frequency of fungal pathogens in autopsy studies of people who died with HIV in Africa: a scoping review 

  Bongomin, Felix; Kibone, Winnie; Atulinda, Linda; Morgan, Bethan; Ocansey, Bright; Storer, Isabelle S.R.; Rhijn, Norman van; Muzoora, Conrad; Denning, David W.; Hamer, Davidson H. (Clinical Microbiology and Infection, 2023)

  Background: Fungal infections are common in HIV-infected individuals and significantly contribute to mortality. However, a substantial number of cases are undiagnosed before death. Objective: To determine the frequency ...
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  Influences on Adherence to Antiretroviral Therapy (ART) in Early-Stage HIV Disease: Qualitative Study from Uganda and South Africa 

  Ware, Norma C.; Wyatt, Monique A.; Pisarski, Emily E.; Bwana, Bosco M.; Orrell, Catherine; Asiimwe, Stephen; Amanyire, Gideon; Musinguzi, Nicholas; Bangsberg, David R.; Haberer, Jessica E.; META Study Team (AIDS and Behavior, 2020)

  Realization of optimal treatment and prevention benefits in the era of universal antiretroviral therapy (ART) and “U=U” (undetectable = untransmittable) requires high adherence at all stages of HIV disease. This article ...
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  Seemingly Unrelated Regression analysis of the Cost and Health-Related Quality of Life Outcomes of the REVAMP randomised clinical trial 

  Rautenberg, Tamlyn A.; Ng, Shu Kay; George, Gavin; Moosa, Mahomed-Yunus S.; McCluskey, Suzanne M.; Gilbert, Rebecca F.; Pillay, Selvan; Aturinda, Isaac; Ard, Kevin L.; Muyindike, Winnie; Musinguzi, Nicholas; Masette, Godfrey; Pillay, Melendhran; Moodley, Pravi; Brijkumar, Jaysingh; Gandhi, Rajesh T.; Johnson, Brent; Sunpath, Henry; Bwana, Mwebesa B.; Marconi, Vincent C.; Siedner, Mark J. (Value in health regional issues, 2023)

  Objective: To evaluate the nine-month cost and health-related quality of life outcomes of resistance versus viral load testing strategies to manage virological failure in low-middle income countries. Methods: We analysed ...
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  Provider perceptions of young people living with HIV and unhealthy alcohol use in Southwestern Uganda: a qualitative study 

  Odokonyero, Raymond Felix ;  Nakasujja, Noeline; Turiho, Andrew ; Sanyu, Naomi ;  Muyindike, Winnie R.; Nansera, Denis ; Semitala, Fred ; Kamya, Moses R. ; Katahoire, Anne R. ; Hahn, Judith A. ; Camlin, Carol C. ; Muhwezi, Wilson W.  (Addiction Science & Clinical Practice, 2024)

  Background: Unhealthy alcohol use is a common public health problem in HIV care settings in Africa and it affects the HIV continuum of care. In Uganda and other low-income countries, HIV care providers are a key resource ...
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  Psychometric assessment of the Runyankole-translated Marlowe-Crowne Social Desirability Scale among persons with HIV in Uganda 

  Silva, Cristina Espinosa da; Fatch, Robin; Emenyonu, Nneka; Muyindike, Winnie; Adong, Julian; Rao, Sowmya R.; Chamie, Gabriel; Ngabirano, Christine; Tumwegamire, Adah; Kekibiina, Allen; Marson, Kara; Beesiga, Brian; Sanyu, Naomi; Katusiime, Anita; Hahn, Judith A. (BMC Public Health, 2024)

  Background: Social desirability can negatively affect the validity of self-reported measures, including underreporting of stigmatized behaviors like alcohol consumption. The Marlowe-Crowne Social Desirability Scale (SDS) ...
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  Diagnostic Prediction Model for Tuberculous Meningitis: An Individual Participant Data Meta-Analysis 

  Stadelman-Behar, Anna M.; Tiffin, Nicki; Ellis, Jayne; Creswell, Fiona V.; Ssebambulidde, Kenneth; Nuwagira, Edwin; Richards, Lauren; Lutje, Vittoria; Hristea, Adriana; et al (The American Journal of Tropical Medicine and Hygiene, 2024)

  No accurate and rapid diagnostic test exists for tuberculous meningitis (TBM), leading to delayed diagnosis. We leveraged data from multiple studies to improve the predictive performance of diagnostic models across different ...
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  Population Effectiveness of Dolutegravir Implementation in Uganda: A Prospective Observational Cohort Study (DISCO), 48-Week Results 

  McCluskey, Suzanne M.; Muyindike, Winnie R.; Nanfuka, Victoria; Omoding, Daniel; Komukama, Nimusiima; Barigye, Ian T.; Kansiime, Lydia; Tumusiime, Justus; Aung, Taing N.; Stuckwisch, Ashley; Hedt-Gauthier, Bethany; Marconi, Vincent C.; Moosa, Mahomed-Yunus S.; Pillay, Deenan; Giandhari, Jennifer; Lessells, Richard; Gupta, Ravindra K.; Siedner, Mark J. (The Journal of Infectious Diseases, 2024)

  Background: Tenofovir/lamivudine/dolutegravir (TLD) is the preferred first-line antiretroviral therapy (ART) regimen for people with HIV (PWH), including those who were previously virologically suppressed on nonnucleoside ...
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  Mid–Upper Arm Circumference Is a Strong Predictor of Mortality Among Ugandan Adults With HIV-Associated Cryptococcal Meningitis: A Prospective Cohort Study 

  Hale, Gila; Adzemovic, Tessa; Hullsiek, Kathy Huppler; Mulwana, Suzan; Ndyetukira, Jane Francis; Sadiq, Alisat; Kabahubya, Mable; Ayebare, Peruth; Nankungu, Lydia; Namudde, Alice; Namanda, Sylvia; Menya, Grace; Nakitto, Grace; Muzoora, Conrad; Nuwagira, Edwin; Rhein, Joshua; Meya, David B.; Boulware, David R.; Ellis, Jayne; Abassi, Mahsa (Open Forum Infectious Diseases, 2024)

  Background: Mortality among adults diagnosed with HIV-associated cryptococcal meningitis remains high (24%–40%). We hypothesized that nutritional state, as measured by mid–upper arm circumference (MUAC), is a potentially ...
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  Death after cure: Mortality among pulmonary tuberculosis survivors in rural Uganda 

  Baluku, Joseph Baruch; Namanda, Brenda; Namiiro, Sharon; Rwabwera, Diana Karungi; Mwesigwa, Gloria; Namaara, Catherine; Twinomugisha, Bright; Nyirazihawe, Isabella; Nuwagira, Edwin; Kansiime, Grace; Kizito, Enock; Nabukenya-Mudiope, Mary G.; Sekadde, Moorine Penninah; Bongomin, Felix; Senfuka, Joshua; Olum, Ronald; Byaruhanga, Aggrey; Munabi, Ian; Kiguli, Sarah (International Journal of Infectious Diseases, 2024)

  Objectives: To determine the incidence of mortality and its predictors among pulmonary tuberculosis (PTB) survivors treated at a rural Ugandan tertiary hospital. Methods: We conducted a retrospective chart review of data ...
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  How Does Antiretroviral Treatment Attenuate the Stigma of HIV? Evidence from a Cohort Study in Rural Uganda 

  Tsai, Alexander C.; . Bangsberg, David R; Bwana, Mwebesa; Haberer, Jessica E.; Frongillo, Edward A.; Muzoora, Conrad; Kumbakumba, Elias; Hunt, Peter W.; Martin, Jeffrey N.; Weiser, Sheri D. (AIDS and Behavior, 2013)

  Program implementers and qualitative researchers have described how increasing availability of HIV antiretroviral therapy (ART) is associated with improvements in psychosocial health and internalized stigma. To determine ...
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  Endoscopically diagnosed hookworm infestation in an adult with chronic iron infestation in an adult with chronic iron deficiency anaemia 

  Abdirahman, Mohamed Mukhtar; Baruhanga, Emmanuel; Muhumuza, Andrew; Wagubi, Robert; Atwine, Raymond; Tumuhimbise, Christine; Tusiime, Florence; Tuhumwire, Caleb; Lumori, Boniface Amanee Elias (South Sudan Medical Journal, 2024)

  Despite advances in hookworm control and prevention campaigns, the prevalence remains high in sub-Saharan Africa. Iron deficiency anaemia is a major complication in those with prolonged infection, a high hookworm burden, ...
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  Oral Lipid Nanocrystal Amphotericin B for Cryptococcal Meningitis: A Randomized Clinical Trial 

  Boulware, David R.; Atukunda, Mucunguzi; Kagimu, Enock; Musubire, Abdu K.; Akampurira, Andrew; Tugume, Lillian; Ssebambulidde, Kenneth; Kasibante, John; Nsangi, Laura; Mugabi, Timothy; Gakuru, Jane; Kimuda, Sarah; Kasozi, Derrick; Namombwe, Suzan; Turyasingura, Isaac; Rutakingirwa, Morris K.; Mpoza, Edward; Kigozi, Enos; Muzoora, Conrad; Ellis, Jayne; Skipper, Caleb P.; Matkovits, Theresa; Williamson, Peter R.; Williams, Darlisha A.; Fieberg, Ann; Hullsiek, Kathy H.; Abassi, Mahsa; Dai, Biyue; Meya, David B. (Clinical Infectious Diseases, 2023)

  Background: Amphotericin B is the gold standard treatment for severe mycoses. A new orally delivered, less-toxic formulation of amphotericin has been developed. Methods: In our randomized clinical trial, we tested oral ...
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  Implementation of a safer conception programme for HIV- affected men and women in rural Uganda 

  Matthews, Lynn T.; Owembabazi, Moran; Tukwasibwe, Deogratius; Najjuma, Alice; Muyindike, Winnie; Tumwine, John Mary; Hornstein, Benjamin; Bassler, John; Long, Dustin; Gill, Elizabeth; Young, Cynthia; Chitneni, Pooja; Psaros, Christina; Kanyesigye, Micheal; Kalyebara, Paul Kato; Kaida, Angela; Bwana, Mwebesa (Global Public Health, 2024)

  We integrated safer conception care into a Ugandan HIV clinic. People with HIV (PWH), or partnered with a PWH, and desiring children were eligible for the Healthy Families Clinic Program. Clients completed quarterly safer ...

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