Department of Peadiatrics and Child Health: Recent submissions
Now showing items 21-40 of 118
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The level of antiretroviral therapy (ART) adherence among orphan children and adolescents living with HIV/AIDS: A systematic review and meta-analysis
(Plos one, 2024)Background: Many children and adolescents living with HIV have ended up as orphans. Due to HIV taking away their parents leaves them deprived of their most important social network and support, which predisposes them to ... -
Cost-effectiveness of community-based household tuberculosis contact management for children in Cameroon and Uganda: a modelling analysis of a cluster-randomised trial
(he Lancet Global Health, 2023)Background: WHO recommends household contact management (HCM) including contact screening and tuberculosis preventive treatment (TPT) for eligible children. The CONTACT trial found increased TPT initiation and completion ... -
Verbal Autopsy to Assess Postdischarge Mortality in Children With Suspected Sepsis in Uganda
(Pediatrics, 2023)Background: Reducing child mortality in low-income countries is constrained by a lack of vital statistics. In the absence of such data, verbal autopsies provide an acceptable method to determining attributable causes of ... -
Real-Time Digital Feedback Device and Simulated Newborn Ventilation Quality
(Pediatrics, 2023)Objectives: Effective bag-valve-mask ventilation is critical for reducing perinatal asphyxia-related abstract neonatal deaths; however, providers often fail to achieve and maintain effective ventilation. The Augmented ... -
Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis
(The Lancet Child & Adolescent Health, 2023)Background: Many children with pulmonary tuberculosis remain undiagnosed and untreated with related high morbidity and mortality. Recent advances in childhood tuberculosis algorithm development have incorporated prediction ... -
Factors Associated with 30-Day in-Hospital Mortality Among Patients Admitted with Severe Covid-19 in Mbarara Regional Referral Hospital
(Infection and drug resistance, 2022)Background: COVID-19 has created a burden on the healthcare system globally. Severe COVID-19 is linked with high hospital mortality. Data regarding 30-day in-hospital mortality and its factors has not been explored in ... -
Transitions from hospital to home: A mixed methods study to evaluate pediatric discharges in Uganda
(PLOS Global Public Health, 2023)The World Health Organization (WHO) Integrated Management of Childhood Illness (IMCI) guidelines recognize the importance of discharge planning to ensure continuation of care at home and appropriate follow-up. However, ... -
Addressing the childhood cancer crisis in sub-Saharan Africa
(The Lancet Oncology, 2023)Sub-Saharan Africa is facing a childhood cancer crisis. Annually, nearly 90% of the more than 100 000 children who develop cancer in sub-Saharan Africa die. By contrast, 85% of paediatric patients with cancer survive in ... -
Poor Seizure Control Among Children Attending a Tertiary 8 Hospital in South Western Uganda – A Retrospective Study [Response to Letter]
(International Journal of General Medicine, 2023)The authors thank Selvi A. Mangundap for the keen interest in our study. The author notes that data obtained using medical records, it is difficult for researchers to determine matters related to the seizure onset, nature, ... -
Four-Month High-Dose Rifampicin Regimens for Pulmonary Tuberculosis
(NEJM Evidence, 2023)Background: Shorter but effective tuberculosis treatment regimens would be of value to the tuberculosis treatment community. High-dose rifampicin has been associated with more rapid and secure lung sterilization and may ... -
A proposed de-identification framework for a cohort of children presenting at a health facility in Uganda
(PLOS Digital Health, 2022)Data sharing has enormous potential to accelerate and improve the accuracy of research, strengthen collaborations, and restore trust in the clinical research enterprise. Nevertheless, there remains reluctancy to openly ... -
Mortality after hospital discharge among children younger than 5 years admitted with suspected sepsis in Uganda: a prospective, multisite, observational cohort study
(The Lancet Child & Adolescent Health, 2023)Background: Substantial mortality occurs after hospital discharge in children younger than 5 years with suspected sepsis, especially in low-income countries. A better understanding of its epidemiology is needed for effective ... -
Utilization of a novel mobile application, “HBB Prompt”, to reduce Helping Babies Breathe skills decay
(PLOS Global Public Health, 2023)Background: Helping Babies Breathe (HBB) is a newborn resuscitation training program designed to reduce neonatal mortality in low- and middle-income countries. However, skills decay after initial training is a significant ... -
Prevalence and Factors Associated With Severe Depression Among Caregivers of Children With Sickle Cell Disease in Northern Uganda
(Research square, 2023)Background: Depression is a mental disorder characterized by depressed mood and affects more than 300 million people globally. Caregivers of children with Sickle cell disease (SCD) experience psychosocial distress which ... -
Acceptability of a new 4-in-1 Abacavir/ Lamivudine/Lopinavir/Ritonavir paediatric fixed-dose combination: the caregiver–child dyads’ perspective
(Therapeutic Advances in Infectious Disease, 2023)Background: Worldwide, 1.7 million children younger than 15 years were living with HIV in 2021. Only 52% of them had access to antiretrovirals (ARVs). Lack of age-appropriate ARV formulations (i.e. easy to swallow for young ... -
Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis
(The Lancet Child & Adolescent Health, 2023)Background: Many children with pulmonary tuberculosis remain undiagnosed and untreated with related high morbidity and mortality. Recent advances in childhood tuberculosis algorithm development have incorporated prediction ... -
Poor Seizure Control Among Children Attending a Tertiary Hospital in South Western Uganda – A Retrospective Study
(International Journal of General Medicine, 2023)Background: Seizure control among children with epilepsy (CWE) receiving anti-seizure medications (ASMs) remains a challenge in low-resource settings. Uncontrolled seizures are significantly associated with increased ... -
Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge clusterrandomised trial
(The Lancet Infectious Diseases, 2022)Background: Tuberculosis diagnosis might be delayed or missed in children with severe pneumonia because this diagnosis is usually only considered in cases of prolonged symptoms or antibiotic failure. Systematic tuberculosis ... -
Rare Late Presentation of Severe Congenital Hemophilia A in a Ugandan Soldier - Case Report
(Authorea Preprints, 2022-03-30)Patients with severe hemophilia are usually diagnosed in infancy due to early onset of abnormal bleeding symptoms that characterize the disease. Affected individuals require coagulation factor routinely or prior to surgical ... -
Prevalence, associated factors and clinical features of congenital syphilis among newborns in Mbarara hospital, Uganda
(BMC Pregnancy and Childbirth, 2020)Background: While congenital syphilis is a significant public health problem that can cause severe disabilities, little is known about the situation in Uganda. We describe prevalence, associated factors and clinical ...
