Research Articles
Browse by
Recent Submissions
-
Sub- and supratherapeutic efavirenz plasma concentrations with risk for HIV therapy failure are mainly genetically explained in Ugandan children: The prospective GENEFA cohort study
(British Journal of Clinical Pharmacology, 2024)Aims: Interindividual variations in efavirenz (EFV) plasma concentrations are extensive, but paediatric data on its consequences for viral control are scarce. The aim of this study was to explore the role of genetic variation ... -
The Impact on Public Health and Economy Using Lockdown as a Tool against COVID-19 Pandemic in Africa: A Perspective
(Journal of Epidemiology and Public Health Reviews, 2020)Background: Since the spread of Corona Virus Disease 19 (COVID-19) most African countries have embarked on a system of either total or partial lockdown and have used it as a tool for curbing the spread of COVID-19. This ... -
Evaluation of antibiotic use among inpatients in surgical ward at Mbarara Regional Referral Hospital, South-Western Uganda
(Infectious Diseases Research, 2023)Objective: The main aim of this study was to evaluate antibiotic use among inpatients in surgical ward at South-Mbarara Regional Referral Hospital, South-Western Uganda. Methodology: A retrospective cross-sectional study ... -
Chemometric Classification of Mangifera indica L. Leaf Cultivars, Based on Selected Phytochemical Parameters; Implications for Standardization of the Pharmaceutical Raw Materials
(Evidence-Based Complementary and Alternative Medicine, 2023)Introduction: Mangifera indica leaves are among the most common materials employed in manufacturing herbal medicinal products. Despite the phytochemical variation of M. indica cultivars, there are no monographs to guide ... -
The Toxicity and Abortifacient Studies of Commelina benghalensis Leaves and Stalk in Wistar Rats
(Acta Scientific Medical Sciences, 2022)Scope of this paper is of Pharmacological relevance. Introduction: The use of plants as a natural medicine has been attached to the culture of different ethnic groups and is practiced worldwide. Thus called traditional ... -
Prevalence and factors associated with drug therapy problems among hypertensive patients at hypertension clinic of Mbarara Regional Referral Hospital, Uganda: a |cross-sectional study
(Therapeutic Advances in Cardiovascular Disease, 2023)Background: Despite the use of safe and effective conventional drugs, drug therapy problems (DTPs) pose a threat to the successful management of hypertension. DTPs are of a great concern in health care because of their ... -
High PrEP uptake and objective longitudinal adherence among HIV-exposed women with personal or partner plans for pregnancy in rural Uganda: A cohort study
(PLoS Medicine, 2023)Background: In Uganda, fertility rates and adult HIV prevalence are high, and many women conceive with partners living with HIV. Pre-exposure prophylaxis (PrEP) reduces HIV acquisition for women and, therefore, infants. ... -
Body composition of type 2 diabetes patients in Uganda: A case-control study
(Journal of public health in Africa, 2023)Introduction: The prevalence of obesity among people diagnosed with Type 2 Diabetes Mellitus (T2DM) has been widely documented. However, the specific composition of this bodyweight remains largely unknown. The study aimed ... -
Diversity of bacterial community in the rhizosphere and bulk soil of Artemisia annua grown in highlands of Uganda
(Plos one, 2023)High land areas in Uganda are suitable for the farming of Artemisia annua. However, harvested A. annua from these areas contain varying concentrations of antimalarial components. This may be attributed to variation in soil ... -
Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats
(Research square, 2023)Background: Species in the genus Vernonia (Asteraceae) are traditionally used in the treatment of different ailments, for example, leaves in both fresh and dry forms have been used in dressing wounds. Anecdotal reports ... -
ADMET profiling and molecular docking of potential antimicrobial peptides previously isolated from African catfish, Clarias gariepinus
(Frontiers in Molecular Biosciences, 2022)Amidst rising cases of antimicrobial resistance, antimicrobial peptides (AMPs) are regarded as a promising alternative to traditional antibiotics. Even so, poor pharmacokinetic profiles of certain AMPs impede their utility ... -
Effect of Covid-19 in Management of Lung Cancer Disease: A Review
(Asian Journal of Pharmaceutical Research and Development, 2022)COVID-19 outcomes may be more severe in lung cancer patients. As a COVID-19 pandemic spreads, it's critical to identify which people and malignancies are most susceptible. COVID-19 appears to have the worst results in lung ... -
Potentially harmful medication use and the associated factors among pregnant women visiting antenatal care clinics in Mbarara Regional Referral Hospital, Southwestern Uganda
(Journal of Clinical and Translational Research, 2023)Background: Pregnancy management using medications has been challenging for both healthcare providers and pregnant women, given the fear of teratogenicity effects and the potential for fetal harm. In the developing world, ... -
A review of breast cancer treatment modalities in uganda - an appraisal of The breast cancer diagnostic process, regulatory approval and supply system of standardized anti-breast cancer medicines
(International Journal of Advanced Research, 2020-02)Breast cancer is the leading cause of cancer death among women and the third incident cancer in the world, contributing 1.7 million of the 17.2 million annual incident cancer cases. For Uganda, breast cancer is the third ... -
Chronic wound isolates and their minimum inhibitory concentrations against third generation cephalosporins at a tertiary hospital in Uganda
(Scientific Reports, 2022)Globally, the burden of chronic wound infections is likely to increase due to the rising levels of bacterial resistance to antibiotics. In the United States of America alone, more than 6.5 million chronicwounds with evidence ... -
When women deliver at home with no one present: Are health care systems in Uganda driving women away?
(Research square, 2019-10-21)Background: Uganda’s maternal mortality remains unacceptably high, with thousands of women and newborns still dying of preventable deaths from pregnancy and childbirth-related complications. Despite the fact that over 95% ... -
Predictors of Medication-Related Emergency Department Admissions Among Patients with Cardiovascular Diseases at Mbarara Regional Referral Hospital, South-Western Uganda
(Open Access Emergency Medicine, 2021)Background: Medication-related emergency department admissions impose a huge and unnecessary burden on the healthcare system. We sought to determine the prevalence and predictors of medication-related emergency department ... -
Sexual and Relationship Benefits of a Safer Conception Intervention Among Men with HIV Who Seek to Have Children with Serodifferent Partners in Uganda
(AIDS and Behavior, 2021-11-19)Many men with HIV (MWH) in Uganda desire children, yet seldom receive reproductive counseling related to HIV care. Because men are under engaged in safer conception programming, they miss opportunities to reap the benefits ... -
Prevalence and factors associated with adverse drug events among patients on dolutegravir‑based regimen at the Immune Suppression Syndrome Clinic of Mbarara Regional Referral Hospital, Uganda: a mixed design study
(AIDS Research and Therapy, 2022)Background: In low income countries such as Uganda progress has been made towards achieving the United Nations AIDS programme 95-95-95 target however efforts are still impeded by pretreatment drug resistance and adverse ... -
A method for the analysis of sugars in biological systems using reductive amination in combination with hydrophilic interaction chromatography and high resolution mass spectrometry
(Talanta, 2017)Separation of sugar isomers extracted from biological samples is challenging because of their natural occurrence as alpha and beta anomers and, in the case of hexoses, in their pyranose and furanose forms. A reductive ...
RSS 1.0