Research Articles: Recent submissions
Now showing items 21-36 of 36
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Phytochemical constituents found in Physalis peruviana L. leaf extracts and their ability to inhibit alpha-glucosidase and scavenge DPPH free radicals in vitro
(Trends in Phytochemical Research (TPR, 2022-03-28)Physalis peruviana L. is widely used in folk medicines to manage diabetes. This study aimed to identify new chemical constituents and explore in vitro antioxidant ability and alpha-glucosidase inhibition activity to explain ... -
Metabolomic Profiling of the Effects of Melittin on Cisplatin Resistant and Cisplatin Sensitive Ovarian Cancer Cells Using Mass Spectrometry and Biolog Microarray Technology
(Metabolites, 2017)In the present study, liquid chromatography-mass spectrometry (LC-MS) was employed to characterise the metabolic profiles of two human ovarian cancer cell lines A2780 (cisplatin-sensitive) and A2780CR (cisplatin-resistant) ... -
An LCMS method for the assay of melittin in cosmetic formulations containing bee venom
(Analytical and Bioanalytical Chemistry, 2015)There is a growing interest in the potential of bee venom in cosmetics as a rejuvenating agent. Products currently on the market do not specify exactly their content of bee venom (BV). Therefore, we developed a method for ... -
Effect of Bee Venom and Its Fractions on the Release of Pro-Inflammatory Cytokines in PMA-Differentiated U937 Cells Co-Stimulated with LPS
(Vaccines, 2016-04-19)The venom of Apis mellifera (honey bee) has been reported to play a role in immunotherapy, but existing evidence to support its immuno-modulatory claims is insufficient. Four fractions from whole bee venom (BV) were separated ... -
Chemical constituents and evidence-based pharmacological properties of Physalis peruviana L.: An overview
(Journal of Herbmed Pharmacology, 2021)Physalis peruviana L. is among plant species possessing evident nutritional, nutraceutical, and commercial interests. This review highlights the complexity of the chemical composition supporting the multiple pharmacotherapeutic ... -
Potential drug-drug interactions on in-patient medication prescriptions at Mbarara Regional Referral Hospital (MRRH) in western Uganda: prevalence, clinical importance and associated factors
(African Health Sciences, 2011)Background: Drug-drug interactions (DDIs) are an important cause of adverse drug reactions. The pharmacoepidemiology of such interactions in hospitals in Uganda is not known. Objectives: To determine the prevalence, ... -
Poor Glycemic Control and the Contributing Factors Among Type 2 Diabetes Mellitus Patients Attending Outpatient Diabetes Clinic at Mbarara Regional Referral Hospital, Uganda
(2021)Background: Glycemic control is associated with long-term complications in type 2 diabetes management. However, updated reports on glycemic control that are crucial to reducing diabetes mellitus complications remain ... -
Pharmacognostic, antiplasmodial and antipyretic evaluation of the aqueous extract of Vernonia amygdalina leaf
(Int. J. Biol. Chem. Sci., 2011)The impeding safety challenges to the use of herbs have made qualitative and quantitative evaluation of herbal preparations a necessity. This study was aimed at evaluating the pharmacognostic and pharmacological properties ... -
Development and validation of a revised instrument to measure burden of long-term medicines use: the Living with Medicines Questionnaire version 3
(Patient Related Outcome Measures, 2018)Methods: New statements were developed and validated through cognitive interviews with medicine users, and these and a global visual analog scale (VAS) were added to the 42-item LMQ-2. Construct validity was assessed ... -
Systematic review and meta-analysis protocol for efficacy and safety of Momordica charantia L. on animal models of type 2 diabetes mellitus
(Systematic Reviews, 2020-01-08)Background: Studies on several preclinical models of type 2 diabetes mellitus have been conducted to establish the hypoglycemic activity of Momordica charantia L. Concerned with appropriateness of these models, we designed ... -
Antidiabetic Medicinal Plants Used in Democratic Republic of Congo: A Critical Review of Ethnopharmacology and Bioactivity Data
(Frontiers in Pharmacology, 2021-10-27)Several studies have been conducted and published on medicinal plants used to manage Diabetes Mellitus worldwide. It is of great interest to review available studies from a country or a region to resort to similarities/d ... -
Antibacterial prescription and the associated factors among outpatients diagnosed with respiratory tract infections in Mbarara Municipality, Uganda
(BMC Pulmonary Medicine, 2021-11-15)Background: Respiratory tract infections (RTI) are the second most frequent diagnosis after Malaria amongst Outpatients in Uganda. Majority are Non pneumonia cough and flu which are self-limiting and often do not require ... -
Acute and Sub-acute Toxicity Evaluation in Rats of PPOJ5 and ADOJ6 Herbal Remedies Used Traditionally in the Management of HIV Infection
(European Journal of Medicinal Plants, 2016-09-27)The use of herbal medicine in the treatment of many ailments is on the rise. It’s a common practice in many rural communities where access to health care is poor but also in the developed world. There is however, no much ... -
Differential Effects of Chronic Ethanol Administration and Withdrawal on -Aminobutyric Acid Type A and NMDA Receptor Subunit Proteins in Male and Female Rat Brain
(2004-06)Background: Investigations have shown that chronic ethanol exposure results in selective alterations in levels of -aminobutyric acid (GABA)A and NMDA receptor subunits. We previously reported significant sex differences ... -
Sublingual Misoprostol versus Intramuscular Oxytocin for Prevention of Postpartum Hemorrhage in Uganda
(PLoS Med, 2014)Background: Postpartum hemorrhage (PPH) is a leading cause of maternal death in sub-Saharan Africa. Although the World Health Organization recommends use of oxytocin for prevention of PPH, misoprostol use is increasingly ... -
Acute toxicity, antipyretic and antinociceptive study of the crude saponin from an edible vegetable
(Int. J. Biol. Chem. Sci., 2012)Vernonia amygdalina is commonly used for food and health purposes. Processing of the leaf for food is aimed at removing bitter tasting antinutritional principles like saponins. This study was designed to determine the ...