dc.contributor.author | Kiptoo, Joshua | |
dc.contributor.author | Yadesa, Tadele Mekuriya | |
dc.contributor.author | Muzoora, Conrad | |
dc.contributor.author | Namugambe, Juliet Sanyu | |
dc.contributor.author | Tamukong, Robert | |
dc.date.accessioned | 2022-06-15T07:41:13Z | |
dc.date.available | 2022-06-15T07:41:13Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Kiptoo, J., Yadesa, T. M., Muzoora, C., Namugambe, J. S., & Tamukong, R. (2021). Predictors of Medication-Related Emergency Department Admissions Among Patients with Cardiovascular Diseases at Mbarara Regional Referral Hospital, South-Western Uganda. Open Access Emergency Medicine: OAEM, 13, 279. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/2131 | |
dc.description.abstract | Background: Medication-related emergency department admissions impose a huge and unnecessary burden on the healthcare system. We sought to determine the prevalence and predictors of medication-related emergency department admissions, among patients with cardiovascular diseases at Mbarara Regional Referral Hospital, Uganda.
Methods: Institutional research ethics approval was secured to conduct a cross-sectional study at the Mbarara Regional Referral Hospital emergency department, between February and September, 2020. All eligible and consenting patients were enrolled in a consecutive manner after a preliminary diagnosis was made by the attending physician. Structured questionnaire interview and comprehensive medication history reviews were used to identify medication therapy problems, in collaboration with a resident physician present on duty. We used sequential categorization for medication therapy problem(s). Descriptive and logistic regression analyses were used to determine prevalence and predictors of medication-related emergency department admissions.
Results: Out of the 128 patients interviewed, 105 (82%) patient admissions were associated with a medication therapy problem: ineffectiveness of drug therapy (53.3%, 56), medication non-adherence (42.9%, 45), and adverse drug reactions (3.8%, 4). Out of a total of 90 incidences of medication non-adherence, 34.4% (31/90) were due to lack of understanding of patient medication regimen, and 27.8% (25/90) due to unaffordable cost of medicines. Female gender (AOR = 4.31 [1.43, 13.03 at 95% CI]; P-value = 0.010]) and a history of tobacco use (AOR = 9.58 [1.14, 80.28 at 95% CI]; P-value = 0.037) were statistically significant predictors of medication-related emergency department admissions in adjusted analysis.
Conclusion: Four in five emergency department admissions were associated with medication-related causes, majorly due to ineffectiveness of drug therapy. Knowledge gap on patient medication regimens was the most prevalent cause for medication non-adherence. Female gender and previous or current tobacco use was an independent risk factor for medication-related admissions. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Open Access Emergency Medicine | en_US |
dc.subject | Adverse drug reaction | en_US |
dc.subject | Ineffective drug therapy | en_US |
dc.subject | Non-adherence | en_US |
dc.subject | Emergency department admission | en_US |
dc.subject | Cardiovascular | en_US |
dc.subject | Uganda | en_US |
dc.title | Predictors of Medication-Related Emergency Department Admissions Among Patients with Cardiovascular Diseases at Mbarara Regional Referral Hospital, South-Western Uganda | en_US |
dc.type | Article | en_US |