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dc.contributor.authorEricson, Jessica E.
dc.contributor.authorBurgoine, Kathy
dc.contributor.authorKumbakumba, Elias
dc.contributor.authorOchora, Moses
dc.contributor.authorHehnly, Christine
dc.contributor.authorBajunirwe, Francis
dc.contributor.authorBazira, Joel
dc.contributor.authorFronterre, Claudio
dc.contributor.authorHagmann, Cornelia
dc.contributor.authorKulkarni, Abhaya V.
dc.contributor.authorKumar, M. Senthil
dc.contributor.authorMagombe, Joshua
dc.contributor.authorMbabazi-Kabachelor, Edith
dc.contributor.authorMorton, Sarah U.
dc.contributor.authorMovassagh, Mercedeh
dc.contributor.authorMugamba, John
dc.contributor.authorMulondo, Ronald
dc.contributor.authorNatukwatsa, Davis
dc.contributor.authorNsubuga, Brian
dc.contributor.authorOlupot-Olupot, Peter
dc.contributor.authorOnen, Justin
dc.contributor.authorSheldon, Kathryn
dc.contributor.authorSmith, Jasmine
dc.contributor.authorSsentongo, Paddy
dc.contributor.authorSsenyonga, Peter
dc.contributor.authorWarf, Benjamin
dc.contributor.authorWegoye, Emmanuel
dc.contributor.authorZhang, Lijun
dc.contributor.authorKiwanuka, Julius
dc.contributor.authorPaulson, Joseph N.
dc.contributor.authorBroach, James R.
dc.contributor.authorSchiff, Steven J.
dc.date.accessioned2022-11-24T06:47:03Z
dc.date.available2022-11-24T06:47:03Z
dc.date.issued2022
dc.identifier.citationEricson, J. E., Burgoine, K., Kumbakumba, E., Ochora, M., Hehnly, C., Bajunirwe, F., ... & Schiff, S. J. (2022). Neonatal Paenibacilliosis: Paenibacillus thiaminolyticus as a Novel Cause of Neonatal Sepsis with High Risk of Sequelae in Uganda. medRxiv.en_US
dc.identifier.urihttp://ir.must.ac.ug/xmlui/handle/123456789/2665
dc.description.abstractPaenibacillus thiaminolyticus may be an underdiagnosed cause of neonatal sepsis. We prospectively enrolled a cohort of 800 neonates presenting with a clinical diagnosis of sepsis at two Ugandan hospitals. Quantitative polymerase chain reaction specific to P. thiaminolyticus and to the Paenibacillus genus were performed on the blood and cerebrospinal fluid (CSF) of 631 neonates who had both specimen types available. Neonates with virus detected in either specimen type were considered to potentially have paenibacilliosis, (37/631, 6%). We described antenatal, perinatal, and neonatal characteristics, presenting signs, and 12-month developmental outcomes for neonates with paenibacillosis vs. clinical sepsis. Median age at presentation was 3 (interquartile range 1, 7) days. Fever (92%), irritability (84%) and seizures (51%) were common. Eleven (30%) had an adverse outcome: 5 (14%) neonates died during the first year of life; 5 of 32 (16%) survivors developed postinfectious hydrocephalus and one (3%) additional survivor had neurodevelopmental impairment without hydrocephalus. These results highlight the need to consider local pathogen prevalence and the possibility of unusual pathogens when determining antibiotic choice for neonatal sepsisen_US
dc.language.isoenen_US
dc.publishermedRxiv.en_US
dc.subjectNeonatal Paenibacilliosisen_US
dc.subjectPaenibacillus thiaminolyticusen_US
dc.subjectNeonatal Sepsisen_US
dc.subjectUgandaen_US
dc.titleNeonatal Paenibacilliosis: Paenibacillus thiaminolyticus as a Novel Cause of Neonatal Sepsis with High Risk of Sequelae in Ugandaen_US
dc.typeArticleen_US


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