dc.contributor.author | Hahn, Judith A. | |
dc.contributor.author | Fatch, Robin | |
dc.contributor.author | Emenyonu, Nneka I. | |
dc.contributor.author | Sanyu, Naomi | |
dc.contributor.author | Katusiime, Anita | |
dc.contributor.author | Levine, Barry | |
dc.contributor.author | Boscardin, W. John | |
dc.contributor.author | Chander, Geetanjali | |
dc.contributor.author | Hutton, Heidi | |
dc.contributor.author | Camlin, Carol S. | |
dc.contributor.author | Woolf-King, Sarah E. | |
dc.contributor.author | Muyindike, Winnie R. | |
dc.date.accessioned | 2023-10-17T09:19:45Z | |
dc.date.available | 2023-10-17T09:19:45Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Hahn, J. A., Fatch, R., Emenyonu, N. I., Sanyu, N., Katusiime, A., Levine, B., ... & Muyindike, W. R. (2023). Effect of two counseling interventions on self-reported alcohol consumption, alcohol biomarker phosphatidylethanol (PEth), and viral suppression among persons living with HIV (PWH) with unhealthy alcohol use in Uganda: A randomized controlled trial. Drug and alcohol dependence, 244, 109783. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/3177 | |
dc.description.abstract | Purpose: To test the efficacy of two interventions to reduce alcohol use and increase viral suppression compared to a control in persons with HIV (PWH).
Methods: In a three-arm (1:1:1) randomized controlled trial (N = 269), we compared in-person counselling (45–70 minutes, two sessions over three months) with interim monthly booster phone calls (live call arm) or twice-weekly automated booster sessions (technology arm) to a brief advice control arm. We enrolled PWH self-reporting unhealthy alcohol use (Alcohol Use Disorders Identification Test – Consumption, prior three months, women ≥3, men ≥4). Primary outcomes were number of self-reported drinking days (NDD) in the prior 21 and biomarker phosphatidylethanol (PEth) at six and nine months and viral suppression (<40 copies/mL) at nine months; we adjusted for sex and baseline outcomes.
Results: At baseline, mean 21-day NDDs were 9.4 (95 % CI: 9.1–9.8), mean PEth was 407.8 ng/mL (95 % CI: 340.7–474.8), and 89.2 % were virally suppressed. At follow-up, there were significant reductions in mean NDDs for the live call versus control arm (3.5, 95 % CI:2.1–4.9, p < 0.001) and for the technology versus control arm (3.6, 95 % CI: 2.2–5.1, p < 0.001). The mean PEth differences compared to the control arm were not significant, i.e. 36.4 ng/mL (95 % CI: -117.5 to 190.3, p = 0.643) for the live call and - 30.9 ng/mL (95 % CI: - 194.8 to 132.9, p = 0.711) for the technology arm. Nine-month viral suppression compared to the control was similar in the live call and in the technology arm.
Conclusion: Intervention effects were found on self-reported NDD but not PEth or viral suppression, suggesting no treatment effect. | en_US |
dc.description.sponsorship | National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Grant #R01 AA024990 and #K24 AA022586. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Drug and alcohol dependence | en_US |
dc.subject | Brief alcohol intervention | en_US |
dc.subject | Unhealthy drinking | en_US |
dc.subject | Phosphatidylethanol | en_US |
dc.subject | Social desirability bias | en_US |
dc.subject | HIV | en_US |
dc.subject | Sub-Saharan Africa | en_US |
dc.title | Effect of two counseling interventions on self-reported alcohol consumption, alcohol biomarker phosphatidylethanol (PEth), and viral suppression among persons living with HIV (PWH) with unhealthy alcohol use in Uganda: A randomized controlled trial | en_US |
dc.type | Article | en_US |