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dc.contributor.authorSemeere, Aggrey
dc.contributor.authorFreeman, Esther
dc.contributor.authorWenger, Megan
dc.contributor.authorGlidden, David
dc.contributor.authorBwana, Mwebesa
dc.contributor.authorKanyesigye, Micheal
dc.contributor.authorAsirwa, Fredrick Chite
dc.contributor.authorRotich, Elyne
dc.contributor.authorBusakhala, Naftali
dc.contributor.authorOga, Emmanuel
dc.contributor.authorJedy-Agba, Elima
dc.contributor.authorKwaghe, Vivian
dc.contributor.authorIregbu, Kenneth
dc.contributor.authorAdebamowo, Clement
dc.contributor.authorJaquet, Antoine
dc.contributor.authorDabis, Francois
dc.contributor.authorPhiri, Sam
dc.contributor.authorBohlius, Julia
dc.contributor.authorEgger, Matthias
dc.contributor.authorYiannoutsos, Constantin T.
dc.contributor.authorWools-Kaloustian, Kara
dc.contributor.authorMartin, Jeffrey
dc.date.accessioned2023-10-23T13:10:19Z
dc.date.available2023-10-23T13:10:19Z
dc.date.issued2017
dc.identifier.citationSemeere, A., Freeman, E., Wenger, M., Glidden, D., Bwana, M., Kanyesigye, M., ... & Martin, J. (2017). Updating vital status by tracking in the community among patients with epidemic Kaposi sarcoma who are lost to follow-up in sub-Saharan Africa. BMC cancer, 17, 1-11.en_US
dc.identifier.urihttp://ir.must.ac.ug/xmlui/handle/123456789/3206
dc.description.abstractBackground: Throughout most of sub-Saharan Africa (and, indeed, most resource-limited areas), lack of death registries prohibits linkage of cancer diagnoses and precludes the most expeditious approach to determining cancer survival. Instead, estimation of cancer survival often uses clinical records, which have some mortality data but are replete with patients who are lost to follow-up (LTFU), some of which may be caused by undocumented death. The end result is that accurate estimation of cancer survival is rarely performed. A prominent example of a common cancer in Africa for which survival data are needed but for which frequent LTFU has precluded accurate estimation is Kaposi sarcoma (KS). Methods: Using electronic records, we identified all newly diagnosed KS among HIV-infected adults at 33 primary care clinics in Kenya, Uganda, Nigeria, and Malawi from 2009 to 2012. We determined those patients who were apparently LTFU, defined as absent from clinic for ≥90 days at database closure and unknown to be dead or transferred. Using standardized protocols which included manual chart review, telephone calls, and physical tracking in the community, we attempted to update vital status amongst patients who were LTFU. Results: We identified 1222 patients with KS, of whom 440 were LTFU according to electronic records. Manual chart review revealed that 18 (4.1%) were classified as LFTU due to clerical error, leaving 422 as truly LTFU. Of these 422, we updated vital status in 78%; manual chart review was responsible for updating in 5.7%, telephone calls in 26%, and physical tracking in 46%. Among 378 patients who consented at clinic enrollment to be tracked if they became LTFU and who had sufficient geographic contact/locator information, we updated vital status in 88%. Duration of LTFU was not associated with success of tracking, but tracking success was better in Kenya than the other sites. Conclusion: It is feasible to update vital status in a large fraction of patients with HIV-associated KS in sub-Saharan Africa who have become LTFU from clinical care. This finding likely applies to other cancers as well. Updating vital status amongst lost patients paves the way towards accurate determination of cancer survivalen_US
dc.description.sponsorshipNational Institute Of Allergy And Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Institute On Drug Abuse (NIDA), National Cancer Institute (NCI), and the National Institute of Mental Health (NIMH), in accordance with the regulatory requirements of the National Institutes of Health under awards U01 AI096299, U01 AI069919, U01 AI069924, D43 CA153717, U54 CA190153, P30 AI027763, T32 AR007098 and the Dermatology Foundation, the President’s Emergency Plan for AIDS Relief (PEPFAR) through the United States Agency for International Development (USAID) under the terms of Cooperative Agreement No. AID-623-A-12-0001.en_US
dc.language.isoen_USen_US
dc.publisherBMC canceren_US
dc.subjectLoss to follow-upen_US
dc.subjectTrackingen_US
dc.subjectTracingen_US
dc.subjectUpdating vital statusen_US
dc.subjectSurvivalen_US
dc.subjectMortalityen_US
dc.subjectKaposi sarcomaen_US
dc.subjectHIV/AIDSen_US
dc.subjectCanceren_US
dc.subjectResource-limited settingsen_US
dc.subjectSub-Saharan Africaen_US
dc.titleUpdating vital status by tracking in the community among patients with epidemic Kaposi sarcoma who are lost to follow-up in sub-Saharan Africaen_US
dc.typeArticleen_US


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