Overview of processed excipients in ocular drug delivery: Opportunities so far and bottlenecks
View/ Open
Date
2023-12-23Author
Ashique, Sumel
Mishra, Neeraj
Mohanto, Sourav
Gowdad, B.H. Jaswanth
Kumar, Shubneesh
Raikar, Amisha S.
Masand, Priya
Garg, Ashish
Goswami, Priyanka
Kahwa, Ivan
Metadata
Show full item recordAbstract
Ocular drug delivery presents a unique set of challenges owing to the complex anatomy and physiology of the eye. Processed excipients have emerged as crucial components in overcoming these challenges and improving the efficacy and safety of ocular drug delivery systems. This comprehensive overview examines the opportunities that processed excipients offer in enhancing drug delivery to the eye. By analyzing the current landscape, this review highlights the successful applications of processed excipients, such as micro- and nano-formulations, sustained-release systems, and targeted delivery strategies. Furthermore, this article delves into the bottlenecks that have impeded the widespread adoption of these excipients, including formulation stability, biocompatibility, regulatory constraints, and cost-effectiveness. Through a critical evaluation of existing research and industry practices, this review aims to provide insights into the potential avenues for innovation and development in ocular drug delivery, with a focus on addressing the existing challenges associated with processed excipients. This synthesis contributes to a deeper understanding of the promising role of processed excipients in improving ocular drug delivery systems and encourages further research and development in this rapidly evolving field.
Collections
- Research Article [136]