Show simple item record

dc.contributor.authorCassidy, Caitlin A.
dc.contributor.authorKabugho, Lydiah
dc.contributor.authorKibaba, Georget
dc.contributor.authorLin, Bradley
dc.contributor.authorHollingsworth, Brandon
dc.contributor.authorBaguma, Emmanuel
dc.contributor.authorJuliano, Jonathan J.
dc.contributor.authorMulogo, Edgar M.
dc.contributor.authorBoyce, Ross M.
dc.contributor.authorCiccone, Emily J.
dc.date.accessioned2024-01-30T09:02:43Z
dc.date.available2024-01-30T09:02:43Z
dc.date.issued2024
dc.identifier.citationCassidy, C. A., Kabugho, L., Kibaba, G., Lin, B., Hollingsworth, B., Baguma, E., ... & Ciccone, E. J. (2024). Comparison of commercially available, rapid, point-of-care C-reactive protein assays among children with febrile illness in southwestern Uganda. PLOS Global Public Health, 4(1), e0002727.en_US
dc.identifier.urihttp://ir.must.ac.ug/xmlui/handle/123456789/3355
dc.description.abstractIn Uganda, children with febrile illness are often treated with antibiotics even though most have self-limiting, likely viral, infections. C-reactive protein (CRP) measurement can help identify those who are more likely to have a bacterial infection and therefore need antibiotic treatment. Implementation of a CRP rapid diagnostic test (RDT) at the point-of-care in resource-constrained settings with minimal laboratory infrastructure could reduce unnecessary antibiotic use. In this study, we evaluated the performance of three semi-quantitative CRP RDTs (Actim, BTNX, Duo) against a reference CRP assay requiring an electrically powered analyzer (Afinion). While both tests demonstrated substantial agreement with Afinion, Actim had slightly higher agreement than BTNX. The sensitivity was higher for the BTNX test, whereas the Actim test had a higher specificity, at cut-offs of 40 mg/L and 80 mg/ L. At a cut-off of 20 mg/L, Duo demonstrated substantial agreement with the Afinion test as well. Our results demonstrate the reliability of CRP RDTs when compared to a reference standard. CRP RDTs without the need for a laboratory-based analyzer are promising tools for optimizing antibiotic use in low-resource settings.en_US
dc.description.sponsorshipEarly Career Award from the Thrasher Research Funden_US
dc.language.isoen_USen_US
dc.publisherPLOS Global Public Healthen_US
dc.subjectPoint-of-care C-reactive proteinen_US
dc.subjectChildrenen_US
dc.subjectFebrile illnessen_US
dc.subjectUgandaen_US
dc.subjectAntimicrobial resistance (AMR)en_US
dc.titleComparison of commercially available, rapid, point-of-care C-reactive protein assays among children with febrile illness in southwestern Ugandaen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

  • Research Articles [456]
    These are different research articles about different Scholars

Show simple item record