dc.contributor.author | Lee, Sulggi | |
dc.contributor.author | Byakwaga, Helen | |
dc.contributor.author | Boum, Yap | |
dc.contributor.author | Burdo, Tricia H. | |
dc.contributor.author | Williams, Kenneth C. | |
dc.contributor.author | Lederman, Michael M. | |
dc.contributor.author | Huang, Yong | |
dc.contributor.author | Tracy, Russell P. | |
dc.contributor.author | Cao, Huyen | |
dc.contributor.author | Haberer, Jessica E. | |
dc.contributor.author | Kembabazi, Annet | |
dc.contributor.author | Bangsberg, David R. | |
dc.contributor.author | Martin, Jeffrey N. | |
dc.contributor.author | Hunt, Peter W. | |
dc.date.accessioned | 2024-02-27T09:37:45Z | |
dc.date.available | 2024-02-27T09:37:45Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Lee, S., Byakwaga, H., Boum, Y., Burdo, T. H., Williams, K. C., Lederman, M. M., ... & Hunt, P. W. (2017). Immunologic pathways that predict mortality in HIV-infected Ugandans initiating antiretroviral therapy. The Journal of infectious diseases, 215(8), 1270-1274. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/3433 | |
dc.description.abstract | The plasma kynurenine/tryptophan (KT) ratio, a marker of adaptive immune defects, strongly predicts mortality during treated human immunodeficiency virus (HIV) disease in Ugandans as compared to US-based populations. Here, the KT ratio and T-cell and plasma biomarkers of immune activation were measured among 535 HIV-infected Ugandans prior to ART initiation and at month 6 of viral suppression. The month 6 KT ratio (adjusted hazard ratio [aHR], 2.74), soluble CD14 level (aHR, 2.32), interleukin 6 level (aHR, 2.34), and D-dimer level (aHR, 1.95) were associated with mortality occurring ≥6 months after ART initiation. The KT ratio remained significantly predictive of mortality even after adjustment for the additional biomarkers, suggesting an independent contribution to clinical outcomes in resource-limited settings. | en_US |
dc.description.sponsorship | National Institutes of Health (grants R56AI100765, R21AI087035, R01AI087145, R01MH054907, P01AI076174, K23GM112526, and P30AI036219), the University of California–San Francisco (UCSF)/Gladstone Institute of Virology and Immunology Center for AIDS Research (grant P30AI027763), the UCSF Clinical and Translational Research Institute Clinical Research Center (grant UL1RR024131), the Center for AIDS Prevention Studies (grant P30MH62246), and the AIDS Cancer Specimen Resource (grant UM1 CA181255) | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | The Journal of infectious diseases | en_US |
dc.subject | HIV | en_US |
dc.subject | Kynurenine | en_US |
dc.subject | Tryptophan | en_US |
dc.subject | D-dimer | en_US |
dc.subject | IL-6 | en_US |
dc.subject | sCD14 | en_US |
dc.subject | Mortality | en_US |
dc.subject | Antiretroviral therapy | en_US |
dc.subject | Africa | en_US |
dc.title | Immunologic Pathways That Predict Mortality in HIV-Infected Ugandans Initiating Antiretroviral Therapy | en_US |
dc.type | Article | en_US |