Show simple item record

dc.contributor.authorIzudi, Jonathan
dc.contributor.authorBajunirwe, Francis
dc.contributor.authorCattamanchic, Adithya
dc.date.accessioned2024-03-05T11:37:18Z
dc.date.available2024-03-05T11:37:18Z
dc.date.issued2024
dc.identifier.citationIzudi, J., Bajunirwe, F., & Cattamanchi, A. (2024). Negative effects of undernutrition on sputum smear conversion and treatment success among retreatment cases in Uganda: A quasi-experimental study. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 100422.en_US
dc.identifier.urihttp://ir.must.ac.ug/xmlui/handle/123456789/3457
dc.description.abstractRationale: The causal relationship between undernutrition and response to anti-tuberculosis (TB) treatment and TB treatment outcomes among people with retreatment TB is understudied. Objective: To evaluate the effect of undernutrition on treatment success and sputum smear conversion among people with retreatment drug-susceptible TB in Kampala, Uganda. Methods: We conducted a quasi-experimental study utilizing propensity score weighting among people with retreatment drug-susceptible TB aged ≥ 15 years treated between 2012 and 2022 in Kampala. The primary exposure was undernutrition assessed using the mid-upper arm circumference at the time of TB diagnosis. The primary outcome was treatment success defined as cure or treatment completion at month 6. Sputum smear conversion was the secondary outcome and was measured as a change in sputum smear status from positive to negative at months 2, 5, and 6. We estimated the causal effect of undernutrition on the outcomes using a propensity-score weighted modified Poisson regression model with robust error variance. Measurements and main results: Of the 605 participants, 432 (71.4 %) were male, 215 (35.5 %) were aged 25–34 years, 427 (70.6 %) had bacteriologically confirmed pulmonary TB, 133 (22.0 %) were undernourished and 398 (65.8 %) achieved treatment success. Of participants with bacteriologically confirmed pulmonary TB, 232 (59.0 %), 327 (59.3 %), and 360 (97.6 %) achieved sputum smear conversion at months 2, 5, and 6, respectively. Undernutrition reduced treatment success (RR 0.42, 95 % CI 0.32–0.55) as well as sputum smear conversion at months 2 (RR 0.45, 95 % CI 0.42–0.49) and 5 (RR 0.46, 95 % CI 0.43–0.51) but not month 6 (RR 0.99, 95 % CI 0.97–1.02). Conclusion: Undernutrition negatively impacts treatment outcomes. Therefore, nutritional assessment should be an integral component of TB care, with nutritional counseling and support offered to those undernourished to optimize their TB treatment response and outcomes.en_US
dc.language.isoen_USen_US
dc.publisherJournal of Clinical Tuberculosis and Other Mycobacterial Diseasesen_US
dc.subjectMalnutritionen_US
dc.subjectPropensity score analysisen_US
dc.subjectSputum smear conversionen_US
dc.subjectTreatment successen_US
dc.subjectTuberculosisen_US
dc.subjectUndernutritionen_US
dc.titleNegative effects of undernutrition on sputum smear conversion and treatment success among retreatment cases in Uganda: A quasi-experimental studyen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

  • Research Articles [456]
    These are different research articles about different Scholars

Show simple item record