Faculty of Medicine: Recent submissions

Now showing items 1141-1160 of 1992

    • An LCMS method for the assay of melittin in cosmetic formulations containing bee venom 

      Tusiimire, Jonans; Wallace, Jennifer; Dufton, Mark; Parkinson, John; Clements, Carol J.; Young, Louise; Park, Jin Kyu; Jeon, Jong Woon; Watson, David G. (Analytical and Bioanalytical Chemistry, 2015)
      There is a growing interest in the potential of bee venom in cosmetics as a rejuvenating agent. Products currently on the market do not specify exactly their content of bee venom (BV). Therefore, we developed a method for ...

    • Effects of the Oral Administration of Aqueous and Methanolic Leaf Extracts of Chenopodium ambrosioides L. (Amaranthaceae) on Blood Glucose Levels in Wistar Rats 

      Kasali, Félicien Mushagalusa; Kadima, Justin Ntokamunda; Tusiimire, Jonans; Ajayi, Clement Olusoji; Agaba, Amon Ganafa (Journal of Experimental Pharmacology, 2022-04-26)
      Background: Diabetes mellitus is a metabolic disorder that poses a major global health threat. The current diabetes mellitus uses insulin and oral hypoglycemic agents, which have limitations, including adverse effects and ...

    • Effect of Bee Venom and Its Fractions on the Release of Pro-Inflammatory Cytokines in PMA-Differentiated U937 Cells Co-Stimulated with LPS 

      Tusiimire, Jonans; Wallace, Jennifer; Woods, Nicola; Dufton, Mark J.; Parkinson, John A.; Abbott, Grainne; Clements, Carol J.; Young, Louise; Park, Jin Kyu; Jeon, Jong Woon; Ferro, Valerie A.; Watson, David G. (Vaccines, 2016-04-19)
      The venom of Apis mellifera (honey bee) has been reported to play a role in immunotherapy, but existing evidence to support its immuno-modulatory claims is insufficient. Four fractions from whole bee venom (BV) were separated ...

    • Prevalence, clinical presentation and factors associated with Uterine fibroids among women attending the Gynecology Outpatient Department at a large Referral Hospital in Southwestern Uganda 

      Adawe, Mariam; Sezalio, Masembe; Kanyesigye, Hamson; Kajabwangu, Rogers; Okello, Samson; Bajunirwe, Francis; Ngonzi, Joseph (East African Science, 2022)
      Background: Uterine fibroids are the most common benign female gynecologic tumors. There are multiple risk factors, including age and reduced fertility. There is however a paucity of data on disease burden and risk factors ...

    • Effect of a solar lighting intervention on fuel-based lighting use and exposure to household air pollution in rural Uganda: A randomized controlled trial 

      Wallach, Eli S.; Lam, Nicholas L.; Nuwagira, Edwin; Muyanja, Daniel; Tayebwa, Mellon; Valeri, Linda; Tsai, Alexander C.; Vallarino, Jose; Allen, Joseph G.; Lai, Peggy S. (Indoor Air, 2022)
      Solar lighting is an alternative to polluting kerosene and other fuel-based lighting devices relied upon by millions of families in resource-limited settings. Whether solar lighting provides sustained displacement of ...

    • Erratum to: The Changing Epidemiology of HIVAssociated Adult Meningitis, Uganda 2015–2017 

      Ellis, Jayne; Bangdiwala, Ananta S.; Cresswell, Fiona V.; Rhein, Joshua; Nuwagira, Edwin; Ssebambulidde, Kenneth; Tugume, Lillian; Rajasingham, Radha; Bridge, Sarah C.; Muzoora, Conrad; Meya, David B.; Boulware, David R. (Open Forum Infectious Diseases, 2019)
      An error appeared in an article published in the September 2019 issue: The Changing Epidemiology of HIV-Associated Adult Meningitis, Uganda 2015–2017. Open Forum Infect Dis. 2019 Sep 29;6(10):ofz419. doi: 10.1093/ofid/ofz419. ...

    • Tuberculous meningitis diagnosis and outcomes during the Xpert MTB/Rif era: a 6.5-year cohort study in Uganda 

      Cresswell, Fiona V.; Bangdiwala, Ananta S.; Bahr, Nathan C.; Trautner, Emily; Nuwagira, Edwin; Ellis, Jayne; Rajasingham, Radha; Rhein, Joshua; Williams, Darlisha A.; Muzoora, Conrad; Elliott, Alison M.; Meya, David B.; Boulware, David R. (Wellcome Open Research, 2018)
      Background: Tuberculous meningitis (TBM), a leading cause of meningitis in sub-Saharan Africa, is notoriously difficult to diagnose. In our Ugandan setting TB diagnostics have evolved rapidly in recent years, with introduction ...

    • Symptomatic Cryptococcal Antigenemia Presenting as Early Cryptococcal Meningitis With Negative Cerebral Spinal Fluid Analysis 

      Ssebambulidde, Kenneth; Bangdiwala, Ananta S.; Kwizera, Richard; Kandole, Tadeo Kiiza; Tugume, Lillian; Kiggundu, Reuben; Mpoza, Edward; Nuwagira, Edwin; Williams, Darlisha A.; Lofgren, Sarah M.; Abassi, Mahsa; Musubire, Abdu K.; Cresswell, Fiona V.; Rhein, Joshua; Muzoora, Conrad; Hullsiek, Kathy Huppler; Boulware, David R.; Meya, David B. (Clinical Infectious Diseases, 2019)
      Background: Individuals with cryptococcal antigenemia are at high risk of developing cryptococcal meningitis if untreated. The progression and timing from asymptomatic infection to cryptococcal meningitis is unclear. We ...

    • Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis 

      Jarvis, J.N.; Lawrence, D.S.; Meya, D.B.; Kagimu, E.; Kasibante, J.; Mpoza, E.; Rutakingirwa, M.K.; Ssebambulidde, K.; Tugume, L.; Rhein, J.; Boulware, D.R.; Mwandumba, H.C.; Moyo, M.; Mzinganjira, H.; Kanyama, C.; Hosseinipour, M.C.; Chawinga, C.; Meintjes, G.; Schutz, C.; Comins, K.; Singh, A.; Muzoora, Conrad; Jjunju, S.; Nuwagira, Edwin; Mosepele, M.; Leeme, T.; Siamisang, K.; Ndhlovu, C.E.; Hlupeni, A.; Mutata, C.; Widenfelt, E. van; Chen, T.; Wang, D.; Hope, W.; Chammard, T. Boyer‑; Loyse, A.; Molloy, S.F.; Youssouf, N.; Lortholary, O.; Lalloo, D.G.; Jaffar, S.; Harrison, T.S. (New England Journal of Medicine, 2022-03-24)
      Background: Cryptococcal meningitis is a leading cause of human immunodeficiency virus (HIV)–related death in sub-Saharan Africa. Whether a treatment regimen that includes a single high dose of liposomal amphotericin B ...

    • Chemical constituents and evidence-based pharmacological properties of Physalis peruviana L.: An overview 

      Kasali, Félicien Mushagalusa; Tuyiringire, Naasson; Peter, Emanuel L.; Ahovegbe, Lucrèce Y.; Ali, Muhammad Shaiq; Tusiimire, Jonans; Ogwang, Patrick Engeu; Kadima, Justin Ntokamunda; Agaba, Amon Ganafa (Journal of Herbmed Pharmacology, 2021)
      Physalis peruviana L. is among plant species possessing evident nutritional, nutraceutical, and commercial interests. This review highlights the complexity of the chemical composition supporting the multiple pharmacotherapeutic ...

    • The effect of sertraline on depression and associations with persistent depression in survivors of HIV-related cryptococcal meningitis 

      Lofgren, Sarah M.; Velamakanni, Sruti S.; Hullsiek, Katherine Huppler; Bangdiwala, Ananta S.; Namudde, Alice; Musubire, Abdu K.; Mpoza, Edward; Abassi, Mahsa; . Pastick, Katelyn A; Nuwagira, Edwin; Evans, Emily E.; Rajsasingham, Radha; . Williams, Darlisha A; Muzoora, Conrad; Creswell, Fiona V.; Rhein, Joshua; Bond, David J.; Nakasujja, Noeline; Meya, David B.; Boulware, David R. (Wellcome Open Research, 2021)
      Background: Depression is a risk factor for worse outcomes in persons living with HIV/AIDS and has a prevalence more than three times as high as in the general population. Despite this, there are few randomized studies of ...

    • Use, cost-effectiveness, and end user perspectives of a home solar lighting intervention in rural Uganda: a mixed methods, randomized controlled trial 

      Sundararajan, Radhika; D’Couto, Helen; Mugerwa, Joseph; Tayebwa, Mellon; Lam, Nicholas L; Wallach, Eli S; Wiens, Matthew O; Ponticiello, Matthew; Stanistreet, Debbi; Tsai, Alexander C; Vallarino, Jose; Allen, Joseph G; Muyanja, Daniel; Shrime, Mark G; Nuwagira, Edwin; Lai, Peggy S (Environmental Research Letters, 2022)
      Energy poverty is prevalent in resource-limited settings, leading households to use inefficient fuels and appliances that contribute to household air pollution. Randomized controlled trials of household energy interventions ...

    • Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial 

      Rhein, Joshua; Huppler, Kathy; Hullsiek; Tugume, Lillian; Nuwagira, Edwin; Mpoza, Edward (Elsevier, 2019-08)
      Background Identifying new antifungals for cryptococcal meningitis is a priority given the inadequacy of current therapy. Sertraline has previously shown in vitro and in vivo activity against cryptococcus. We aimed to ...

    • Impact of a solar lighting intervention on social determinants of health in rural Uganda: a mixed methods, randomized controlled trial 

      Sundararajan, Radhika; D’Couto, Helen; Mugerwa, Joseph; Tayebwa, Mellon; Lam, Nicholas; Wallach, Eli; Wiens, Matthew; Stanistreet, Debbi; Tsai, Alexander C.; Vallarino, Jose; Allen, Joseph G.; Muyanja, Daniel; Nuwagira, Edwin; Lai, Peggy S. (2021)
      Background. Clinical trials to reduce household air pollution have largely focused on cookstoves and have been in part limited by suboptimal adoption of cleaner cooking technologies. Less is known about the adoption and ...

    • High Mortality Associated with Unmasking Cryptococcal Meningitis 

      Rhein, Joshua; Hullsiek, Kathy Huppler; Bahr, Nathan C; Tugume, Lillian; Nuwagira, Edwin; Ssebambulidde, Kenneth; Kiggundu, Reuben; Evans, Emily E; Mpoza, Edward; Williams, Darlisha A; Abassi, Mahsa; Musubire, Abdu; Muzoora, Conrad; Meya, David B; Boulware, David R (Boston, 2018)
      Introduction: Increased antiretroviral therapy (ART) availability in Africa has led to more patients developing cryptococcosis after ART initiation. Despite this changing epidemiology, data regarding cryptococcal meningitis ...

    • Hearing loss among patients on treatment for drug-resistant tuberculosis in Uganda 

      Lodiong, Lodiong Jackson Dumo; Amos, Timbine; Lumori, Boniface Amanee Elias; Nuwagira, Edwin (South Sudan Medical Journal, 2021-08)
      Introduction: Second-line injectable therapy using aminoglycosides (AG) like kanamycin, amikacin or capreomycin is associated with irreversible hearing loss. We aimed to determine the incidence and predictors of hearing ...

    • Population Pharmacokinetics and Significant Under-Dosing of Anti-Tuberculosis Medications in People with HIV and Critical Illness 

      Rao, Prakruti S.; Moore, Christopher C.; Mbonde, Amir A.; Nuwagira, Edwin; Orikiriza, Patrick; Nyehangane, Dan; Al-Shaer, Mohammad H.; Peloquin, Charles A.; Gratz, Jean; Pholwat, Suporn; Arinaitwe, Rinah; Boum, Yap; Mwanga-Amumpaire, Juliet; Houpt, Eric R.; Kagan, Leonid; Heysell, Scott K.; Muzoora, Conrad (Antibiotics, 2021)
      Critical illness from tuberculosis (TB) bloodstream infection results in a high case fatality rate for people living with human immunodeficiency virus (HIV). Critical illness can lead to altered pharmacokinetics and ...

    • The Changing Epidemiology of HIV-Associated Adult Meningitis, Uganda 2015–2017 

      Ellis, Jayne; Bangdiwala, Ananta S.; Cresswell, Fiona V.; Rhein, Joshua; Nuwagira, Edwin; Ssebambulidde, Kenneth; Tugume, Lillian; Rajasingham, Radha; Bridge, Sarah C.; Muzoora, Conrad; Meya, David B.; Boulware, David R. (In Open forum infectious diseases, 2019)
      Background. Central nervous system (CNS) infections remain a major public health problem in Sub-Saharan Africa, causing 15%–25% of AIDS-related deaths. With widespread availability of antiretroviral therapy (ART) and the ...

    • Gender differences among patients with drug resistant tuberculosis and HIV co‑infection in Uganda: a countrywide retrospective cohort study 

      Baluku, Joseph Baruch; Mukasa, David; Bongomin, Felix; Stadelmann, Anna; Nuwagira, Edwin; Haller, Sabine; Ntabadde, Kauthrah; Turyahabwe, Stavia (BMC Infectious Diseases, 2021)
      Background: Gender differences among patients with drug resistant tuberculosis (DRTB) and HIV co-infection could affect treatment outcomes. We compared characteristics and treatment outcomes of DRTB/HIV co-infected men and ...

    • Standardized Urine-Based Tuberculosis (TB) Screening With TB-Lipoarabinomannan and Xpert MTB/RIF Ultra in Ugandan Adults With Advanced Human Immunodeficiency Virus Disease and Suspected Meningitis 

      Cresswell, Fiona V.; Ellis, Jayne; Kagimu, Enock; Bangdiwala, Ananta S.; Okirwoth, Michael; Mugumya, Gerald; Rutakingirwa, Morris; Kasibante, John; Quinn, Carson M.; Ssebambulidde, Kenneth; Rhein, Joshua; Nuwagira, Edwin; Tugume, Lillian; Martyn, Emily; Skipper, Caleb P.; Muzoora, Conrad; Grint, Daniel; Meya, David B.; Bahr, Nathan C.; Elliott, Alison M.; Boulware, David R. (In Open forum infectious diseases, 2020)
      Background. Diagnosis of extrapulmonary tuberculosis (TB) remains challenging. We sought to determine the prevalence of disseminated TB by testing urine with TB-lipoarabinomannan (TB-LAM) lateral flow assay and Xpert MTB/RIF ...