Faculty of Medicine: Recent submissions
Now showing items 1161-1180 of 1992
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Evaluation of the BioFire FilmArray Meningitis/Encephalitis panel in an adult and pediatric Ugandan population
(Journal of Medical Mycology, 2021)Background: Meningitis causes significant mortality in sub-Saharan Africa and limited diagnostics exist. We evaluated the utility of the BioFire_ FilmArray_ Meningitis/Encephalitis multiplex PCR panel (BioFire ME) in ... -
Drug-Resistant Tuberculosis Presenting as a Testicular Mass: A Case Report
(International Medical Case Reports Journal, 2021)Background: Extrapulmonary drug-resistant tuberculosis is extremely rare and is almost always associated with poor treatment outcomes. This is partly due to the difficulty in confirming the diagnosis. Case Presentation: ... -
Renal Tubular Dysfunction Among People Living with HIV on Tenofovir Disoproxil Fumarate in Uganda: A Hospital-Based Cross-Sectional Study
(Reserach square, 2022)Background Tenofovir Disoproxil Fumarate (TDF), the most commonly prescribed antiretroviral drug globally is associated with renal tubular dysfunction (RTD) whose magnitude is poorly understood in resource limited settings. ... -
Detrimental Outcomes of Unmasking Cryptococcal Meningitis With Recent ART Initiation
(In Open forum infectious diseases, 2018)Background: Increased antiretroviral therapy (ART) availability has been associated with more patients developing cryptococcosis after ART initiation. Despite this changing epidemiology, data regarding cryptococcal meningitis ... -
Obstructive lung disease and quality of life after cure of multi-drug-resistant tuberculosis in Uganda: a cross-sectional study
(Tropical medicine and health, 2020)Background: Pulmonary multi-drug-resistant tuberculosis (MDR TB) alters lung architecture and involves lengthy treatment duration, high pill burden, drug adverse effects, travel restrictions, and stigma. Literature about ... -
Incidence and risk predictors of acute kidney injury among HIV-positive patients presenting with sepsis in a low resource setting
(BMC nephrology, 2021)Background: Acute kidney injury (AKI) is a frequently encountered clinical condition in critically ill patients and is associated with increased morbidity and mortality. In our resource-limited setting (RLS), the most ... -
Cryptococcosis in pregnancy and the postpartum period: Case series and systematic review with recommendations for management
(Medical Mycology, 2020)Cryptococcal meningitis causes 15% of AIDS-related deaths. Optimal management and clinical outcomes of pregnant women with cryptococcosis are limited to case reports, as pregnant women are often excluded from research. ... -
Cerebrospinal Fluid Lactate as a Prognostic Marker of Disease Severity and Mortality in Cryptococcal Meningitis
(Clinical Infectious Diseases, 2021)Background: Cerebrospinal fluid (CSF) lactate levels can be used to differentiate between bacterial and viral meningitis. We measured CSF lactate in individuals with cryptococcal meningitis to determine its clinical ... -
Cerebrospinal Fluid Early Fungicidal Activity as a Surrogate Endpoint for Cryptococcal Meningitis Survival in Clinical Trials
(Clinical Infectious Diseases, 2020)Background: In cryptococcal meningitis phase 2 clinical trials, early fungicidal activity (EFA) of Cryptococcus clearance from cerebrospinal fluid (CSF) is used as a surrogate endpoint for all-cause mortality. The Food and ... -
Can improved diagnostics reduce mortality from Tuberculous meningitis? Findings from a 6.5-year cohort in Uganda [version 1; referees: awaiting peer review]
(Wellcome Open Research, 2018-05-29)Background: Tuberculous meningitis (TBM) is the second most common cause of meningitis in sub-Saharan Africa and is notoriously difficult to diagnose. We describe the impact of improved TBM diagnostics over 6.5 years at ... -
Blood neutrophil counts in HIV-infected patients with cryptococcal meningitis: Association with mortality
(PLoS ONE, 2018)Background: The mortality from cryptococcal meningitis remains high, despite the availability of antiretroviral therapy (ART) and amphotericin-based fungal regimens. The role of neutrophils in cryptococcosis is controversial. ... -
Impact of DNA Extraction Method on Variation in Human and Built Environment Microbial Community and Functional Profiles Assessed by Shotgun Metagenomics Sequencing
(Frontiers in microbiology, 2020)Both the host microbiome and the microbiome of the built environment can have profound impacts on human health. While prior studies have suggested that the variability introduced by DNA extraction method is less than typical ... -
Tuberculosis in HIV-Associated Cryptococcal Meningitis is Associated with an Increased Risk of Death
(Journal of Clinical Medicine, 2020)Tuberculosis (TB) and cryptococcal meningitis are leading causes of morbidity and mortality in advanced HIV disease. Data are limited on TB co-infection among individuals with cryptococcal meningitis. We performed a ... -
Impact of biological sex on cryptococcal meningitis mortality in Uganda and South Africa
(Medical Mycology, 2021)The role of biological sex on clinical outcomes and the pathogenesis of AIDS-related opportunistic infections is unknown. We assessed baseline biomarkers and outcomes between 577 men and 400 women in HIV-related cryptococcal ... -
Minor gynecologic surgery: A review of the training experience and skill building opportunities for providers in low and middle income countries
(Open Journal of Obstetrics and Gynecology, 2014)Purpose: Minor gynecologic surgery is the cornerstone of gynecologic evaluation and intervention in countries with a well-established medical infrastructure. Surgical training and exposure to minor procedures are not ... -
Post-discharge infections and healthcare contact in ugandan women hospitalized for delivery
(American Journal of Obstetrics & Gynecology, 2017)Objectives: Postpartum infection is a common cause of pregnancy related morbidity. Data are lacking from resource-limited settings on post-discharge febrile morbidity and healthcare contact in women with in-hospital ... -
Outcomes of patients with severe sepsis after the first 6 hours of resuscitation at a regional referral hospital in Uganda
(Journal of Critical Care, 2016)Introduction: The optimal resuscitation strategy for patients with severe sepsis in resource-limited settings is unknown. Therefore, we determined the association between intravenous fluids, changes in vital signs and ... -
Out of pocket costs and time/productivity losses for pediatric sepsis in Uganda: a mixed-methods study
(BMC Health Services Research, 2021)Background: Sepsis disproportionately affects children from socioeconomically disadvantaged families in low-resource settings, where care seeking may consume scarce family resources and lead to financial hardships. Those ... -
Surgical, Obstetric, and Anesthetic Mortality Measurement at a Ugandan Secondary Referral Hospital
(Anesthesia & Analgesia, 2021)Background: The health care systems of low-income countries have severely limited capacity to treat surgical diseases and conditions. There is limited information about which hospital mortality outcomes are suitable metrics ... -
Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial
(Lancet, 2017-04-26)Background: Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed to assess the effects of early ...