Faculty of Medicine: Recent submissions

Now showing items 701-720 of 1988

    • Capacity Building in Sub-Saharan Africa as Part of the INTENSE-TBM Project During the COVID-19 Pandemic 

      Ariza-Vioque, E.; Ello, F.; Andriamamonjisoa, H.; Machault, V.; Gonza´lez-Martın, J.; Calvo-Cortes, M. C.; Eholie, S.; Tchabert, G. A.; Ouassa, T.; Raberahona, M.; Rakotoarivelo, R.; Razafindrakoto, H.; Rahajamanana, L.; Wilkinson, R. J.; Davis, A.; Maxebengula, M.; Abrahams, F.; Muzoora, Conrad; Nakigozi, N.; Nyehangane, D.; Nanjebe, D.; Mbega, H.; Kaitano, R.; Bonnet, M.; Debeaudrap, P.; Miro´, J. M.; Anglaret, X.; Rakotosamimanana, N.; Calmy, A.; Bonnet, F.; Ambrosioni, J.; INTENSE-TBM Group (Infectious Diseases and Therapy, 2022)
      Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), with at least 100,000 cases per year and a mortality rate of up to 50% in individuals co-infected with human immunodeficiency virus ...

    • Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-Saharan Africa: an economic analysis of the AMBITION-cm trial 

      Lawrence, David S; Muthoga, Charles; Meya, David B; Tugume, Lillian; Williams, Darlisha; Rajasingham, Radha; Boulware, David R; Mwandumba, Henry C; Moyo, Melanie; Dziwani, Eltas N; Maheswaran, Hendramoorthy; Kanyama, Cecilia; Hosseinipour, Mina C; Chawinga, Chimwemwe; Meintjes, Graeme; Schutz, Charlotte; Comins, Kyla; Bango, Funeka; Muzoora, Conrad; Jjunju, Samuel; Nuwagira, Edwin; Mosepele, Mosepele; Leeme, Tshepo; Ndhlovu, Chiratidzo E; Hlupeni, Admire; Shamu, Shepherd; Boyer-Chammard, Timothée; Molloy, Síle F; Youssouf, Nabila; Chen, Tao; Shiri, Tinevimbo; Jaffar, Shabbar; Harrison, Thomas S; Jarvis, Joseph N; Niessen, Louis W (The Lancet Global Health, 2022)
      Background HIV-associated cryptococcal meningitis is a leading cause of AIDS-related mortality. The AMBITION-cm trial showed that a regimen based on a single high dose of liposomal amphotericin B deoxycholate (AmBisome ...

    • Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors 

      Umviligihozo, Gisele; Mann, Jaclyn K.; Jin, Steven W.; Mwimanzi, Francis M.; Hsieh, Hua-Shiuan A.; Sudderuddin, Hanwei; Lee, Guinevere Q.; Byakwaga, Helen; Muzoora, Conrad; Hunt, Peter W.; Martin, Jeff N.; Haberer, Jessica E.; Karita, Etienne; Allen, Susan; Hunter, Eric; Brumme, Zabrina L.; Brockman, Mark A. (Frontiers in virology, 2022)
      HIV-1 accessory proteins Nef and Vpu enhance viral pathogenesis through partially overlapping immune evasion activities. Attenuated Nef or Vpu functions have been reported in individuals who display slower disease progression, ...

    • A secondary analysis of depression outcomes from a randomized controlled trial of adjunctive sertraline for HIV associated cryptococcal meningitis 

      Lofgren, Sarah M.; Velamakanni, Sruti S.; Hullsiek, Katherine Huppler; Bangdiwala, Ananta S.; Namudde, Alice; Musubire, Abdu K.; Mpoza, Edward; Abassi, Mahsa; Pastick, Katelyn A.; Nuwagira, Edwin; Evans, Emily E.; Rajsasingham, Radha; Williams, Darlisha A.; Muzoora, Conrad; Creswell, Fiona V.; Rhein, Joshua; Bond, David J.; Nakasujja, Noeline; Meya, David B.; Boulware, David R. (Wellcome Open Research, 2022)
      Background: Depression is a risk factor for worse HIV outcomes in persons living with HIV/AIDS, including engagement-in-care, HIV medication adherence, and retention-in-care. Depression has a prevalence of more than three ...

    • Association of Hyponatremia on Mortality in Cryptococcal Meningitis: A Prospective Cohort 

      Tugume, Lillian; Fieberg, Ann; Ssebambulidde, Kenneth; Nuwagira, Edwin; Williams, Darlisha A.; Mpoza, Edward; Rutakingirwa, Morris K.; Kagimu, Enoch; Kasibante, John; Nsangi, Laura; Jjunju, Samuel; Musubire, Abdu K.; Muzoora, Conrad; Lawrence, David S.; Rhein, Joshua; Meya, David B.; Hullsiek, Kathy Huppler; Boulware, David R.; Abassiand, Mahsa; For the Adjunctive Sertraline for HIV-Associated Cryptococcal Meningitis (ASTRO-CM) Team (Open Forum Infectious Diseases, 2022-06-17)
      Background: Sodium abnormalities are frequent in central nervous system infections and may be caused by cerebral salt wasting, syndrome of inappropriate antidiuretic hormone secretion, or medication adverse events. In ...

    • In-Vivo and In-silico Studies Revealed the Molecular Mechanisms of Colocasia esculenta Phenolics as Novel Chemotherapy against Benign Prostatic Hyperplasia via inhibition of 5α‒Reductase and α1-Adrenoceptor. 

      Tusubira, Deusdedit; Munezero, Jonasi; Agu, Peter Chinedu; Ajayi, Clement Olusoji; Oloro, Joseph; Namale, Nathiim; Ssedyabane, Frank; Nakiguli, Caroline Kiwanuka; Adegboyega, Abayomi E.; Aja, Patrick Maduabuchi (Research Square, 2023)
      Benign Prostatic Hyperplasia (BPH) is a major cause of lower urinary tract infections and erectile dysfunction thus a major contributor to lowering the quality of life among older men. In this study, we investigated the ...

    • Understanding the barriers and enablers for postgraduate medical trainees becoming simulation educators: a qualitative study 

      Muhumuza, Albert; Najjuma, Josephine Nambi; MacIntosh, Heather; Sharma, Nishan; Singhal, Nalini; Hollaar, Gwendolyn L; Wishart, Ian; Bajunirwe, Francis; Santorino, Data (BMC Medical Education, 2023)
      Introduction: There is increasing evidence that Simulation-based learning (SBL) is an effective teaching method for healthcare professionals. However, SBL requires a large number of faculty to facilitate small group sessions. ...

    • In-vitro Antibacterial Activity of Allium sativum on Common Food Poisoning Bacteria 

      Ssemwanga, Elastus; Mulungi, Priscillah N.; Tumusiime, Jazira; Dhihume, Willy; Arinaitwe, Bruce; Ssedyabane, Frank; Rugera, Simon Peter; Ajayi, Clement Olusoji; Omara, Denis (Journal of Advances in Microbiology, 2022)
      Background: The use of herbal medicines for food poisoning in inadequate resource countries has greatly increased with the limited establishment of antibacterial activity. This study aimed at establishing the antibacterial ...

    • Retrospective in silico mutation profiling of SARS-CoV-2 structural proteins circulating in Uganda by July 2021: Towards refinement of COVID-19 disease vaccines, diagnostics, and therapeutics 

      Odongo, Steven; Okella, Hedmon; Ndekezi, Christian; Okee, Moses; Namayanja, Monica; Mujuni, Brian; Sterckx, Yann G. J.; Kizito, Dennison; Radwanska, Magdalena; Magez, Stefan; Ikwap, Kokas; Mwiine, Frank Nobert; Lutwama, Julius Julian; Ibingira, Charles (Plos one, 2022)
      The SARS-CoV-2 virus, the agent of COVID-19, caused unprecedented loss of lives and economic decline worldwide. Although the introduction of public health measures, vaccines, diagnostics, and therapeutics disrupted the ...

    • SARS-CoV-2 vaccine development 

      Mtewa, Andrew G.; Amanjot, Annu; Lampiao, Fanuel; Okella, Hedmon; Weisheit, Anke; Tolo, Casim U.; Ogwang, Patrick (Coronavirus Drug Discovery, 2022)
      Vaccine development is the entire process involved in the designing of a vaccine to the post release study period. Vaccines work against viruses, bacteria, fungi and parasites. The design in which an antiviral vaccine is ...

    • Factors Associated With In-Hospital Post–Cardiac Arrest Survival in a Referral Level Hospital in Uganda 

      Alum, Rachel Aguma; Kiwanuka, Joseph Kyobe; Nakku, Doreen; Kakande, Elijah Ronald; Nyaiteera, Victoria; Ttendo, Stephen Senyonjo (Anesthesia & Analgesia, 2022)
      Background: Cardiac arrest (CA) is still associated with high mortality and morbidity across all practice settings despite resuscitation attempts and advancements in its management. Patient outcomes vary and are affected ...

    • Novel FujiLAM assay to detect tuberculosis in HIV-positive ambulatory patients in four African countries: a diagnostic accuracy study 

      Huerga, Helena; Bastard, Mathieu; Lubega, Alex Vicent; Akinyi, Milcah; Antabak, Natalia Tamayo; Ohler, Liesbet; Muyindike, Winnie; Taremwa, Ivan Mugisha; Stewart, Rosanna; Bossard, Claire; Nkosi, Nothando; Ndlovu, Zibusiso; Hewison, Catherine; Stavia, Turyahabwe; Okomo, Gordon; Ogoro, Jeremiah Okari; Ngozo, Jacqueline; Mbatha, Mduduzi; Aleny, Couto; Wanjala, Stephen; Musoke, Mohammed; Atwine, Daniel; Ascorra, Alexandra; Ardizzoni, Elisa; Casenghi, Martina; Ferlazzo, Gabriella; Nakiyingi, Lydia; Gupta-Wright, Ankur; Bonnet, Maryline (The Lancet Global Health, 2023)
      Background: Development of rapid biomarker-based tests that can diagnose tuberculosis using non-sputum samples is a priority for tuberculosis control. We aimed to compare the diagnostic accuracy of the novel Fujifilm SILVAMP ...

    • Suicide related to the COVID‑19 pandemic in India: A systematic review 

      Al‑Mamun, Firoj; Kaggwa, Mark Mohan; Hosen, Ismail; Sikder, Md. Tajuddin; Griffiths, Mark D.; Mamun, Mohammed A. (Discover Psychology, 2023)
      Background: The suicide rate has increased during the pandemic in India. Moreover, several studies, especially pressmedia reporting suicide studies have been conducted but no systematic review has been attempted in this ...

    • Stigma of infidelity associated with condom use explains low rates of condom uptake: qualitative data from Uganda and Tanzania 

      Broderick, Kathryn; Aristide, Christine; Bullington, Brooke W.; Amumpaire, Juliet Mwanga; Downs, Jennifer A.; Sundararajan, Radhika (Reproductive Health, 2023)
      Despite widespread messaging supporting male (external) condom use to prevent HIV in endemic settings, utilization of condoms is low across sub-Saharan Africa. A thorough understanding of barriers to condom use as a form ...

    • Psychological distress and associated factors among hospital workers in Uganda during the COVID-19 lockdown – A multicentre study 

      Kirabira, Joseph; Forry, Jimmy Ben; Ssebuufu, Robinson; Akimana, Benedict; Nakawuki, Madrine; Anyayo, Lucas; Mpamizo, Emmanuel; Onen, Bruno Chan; Ingabire, Jane; Gumisiriza, Nolbert; Waiswa, Ali; Mawanda, Anatoli; Ashaba, Scholastic; Kyamanywa, Patrick (Heliyon, 2022)
      Objective: To assess the prevalence of psychological distress (PD), and its associated demographic, psychosocial, hospital and health-related factors among hospital workers in Uganda during the COVID-19 related lockdown. Methods: ...

    • Effect of Covid-19 in Management of Lung Cancer Disease: A Review 

      Kumar, Roshan; Saha, Purabi; Nyarko, Richard Owusu; Lokare, Priya; dubey, Anubhav; Boateng, Edward; Kahwa, Ivan; Boateng, Paul Owusu; Asum, Christian (Asian Journal of Pharmaceutical Research and Development, 2022)
      COVID-19 outcomes may be more severe in lung cancer patients. As a COVID-19 pandemic spreads, it's critical to identify which people and malignancies are most susceptible. COVID-19 appears to have the worst results in lung ...

    • Demographics, referral patterns and outcome of neural tube defect patients in Southwestern Uganda 

      Punchak, Maria; Najjuma, Josephine Nambi; Razak, Shahaan; Nakaziba, Zaina; Kasoba, Amos Mbusa; Haglund, Michael M.; Fuller, Anthony T.; Kitya, David (Research square, 2023)
      Purpose: In Uganda, the burden of neural tube defects (NTDs) poses a serious neurosurgical and public health challenge; however, published data on this patient population is lacking. We sought to characterize the NTD patient ...

    • Contribution of community health workers to the treatment of common illnesses among under 5‑year‑olds in rural Uganda 

      Bagenda, Fred; Wesuta, Andrew Christopher; Stone, Geren; Ntaro, Moses; Patel, Palka; Kenney, Jessica; Baguma, Stephen; Ayebare, David Santson; Bwambale, Shem; Matte, Michael; Kawungezi, Peter Chris; Mulogo, Edgar Mugema (Malaria Journal, 2022)
      Background: The control of malaria, pneumonia, and diarrhoea is important for the reduction in morbidity and mortality among children under 5 years. Uganda has adopted the Integrated Community Case Management strategy using ...

    • Challenges and Fears of Adolescents and Young Adults Living with HIV Facing Transition to Adult HIV Care 

      Ashaba, Scholastic; Zanoni, Brian C.; Baguma, Charles; Tushemereirwe, Patricia; Nuwagaba, Gabriel; Kirabira, Joseph; Nansera, Denis; Maling, Samuel; Tsai, Alexander C. (AIDS and Behavior, 2022)
      Adolescents and young adults living with perinatally-acquired HIV (AYLPHIV) have poor outcomes along each step of the HIV care continuum due to challenges in seeking care and advocating for themselves. The transition from ...

    • Prevalence of prediabetes and associated factors among community members in Rural Isingiro district 

      Ampeire, Isaac Petit; Kawugezi, Peter Chris; Mulogo, Edgar Mugema (Research square, 2022)
      Background: In rural Uganda many people are either pre-diabetic or diabetic, however they do not know that these conditions afflict them. The burden of pre-diabetes in rural Isingiro had not previously been determined. The ...