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A call to bridge the diagnostic gap: diagnostic solutions for neonatal sepsis in low- and middle- income countries
(BMJ global health, 2024)The first month of life is the most critical period for an infant’s survival, yet the most neglected for the provision of quality care. Each year, an estimated 2.3 million neonates die in their first month of life.1 Sepsis ... -
Prevalence and factors associated with suicidal behaviors among domestic workers
(Discover Psychology, 2024)Background: Due to urbanization and changes in family structure, the need for domestic workers has surged in many developing countries, including Rwanda. While being employed as a domestic worker presents financial benefits ... -
Community readiness and acceptance for the implementation of a novel malaria vaccine among at-risk children in sub-saharan Africa: a systematic review protocol
(Malaria Journal, 2024)Background: The World Health Organization novel malaria vaccine for at-risk children has the potential to greatly reduce the current malaria burden in sub-Saharan Africa. However, most studies have reported contradictory ... -
The 2024 Pediatric Sepsis Challenge: Predicting In-Hospital Mortality in Children With Suspected Sepsis in Uganda
(Pediatric Critical Care Medicine, 2024)The aim of this “Technical Note” is to inform the pediatric critical care data research community about the “2024 Pediatric Sepsis Data Challenge.” This competition aims to facilitate the development of open-source algorithms ... -
Clinical profiles, incidence and predictors of early neonatal mortality at Mbarara Regional Referral Hospital, south-western Uganda
(BMC pediatrics, 2024)Background: The current neonatal mortality rate in Uganda is high at 22 deaths per 1000 live births, while it had been stagnant at 27 deaths per 1000 live births in the past decade. This is still more than double the World ... -
Primary Healthcare Workers’ Awareness of Acute Rheumatic Fever & Rheumatic Heart Disease: A Study in Public Health Facilities in South Western Uganda
(Pediatric Health, Medicine and Therapeutics, 2024)Introduction: Timely identification and treatment of a streptococcal throat infection prevents acute rheumatic fever (ARF) and its progression to Rheumatic Heart Disease (RHD). However, children in developing countries ... -
Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria
(Malaria journal, 2012)Background: Plasmodium falciparum histidine-rich protein PFHRP2 measurement is used widely for diagnosis, and more recently for severity assessment in falciparum malaria. The Pfhrp2 gene is highly polymorphic, with deletion ... -
Diagnosing Severe Falciparum Malaria in Parasitaemic African Children- a Prospective Evaluation of Plasma Pf HRP2 Measurement
(PLOS Medicine, 2012)Background: In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidental Plasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein ... -
Prospective cohort study of the feasibility and yield of household child tuberculosis contact screening in Uganda
(The International Journal of Tuberculosis and Lung Disease, 2017)Setting: Screening and isoniazid preventive therapy (IPT) of child contacts of tuberculosis (TB) patients is poorly implemented in resource-limited countries, in part due to difficulties in TB diagnosis in children. ... -
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
(The Lancet, 2010)Background: Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from ... -
“Everything is a Mess”: How COVID‑19 is Impacting Engagement with HIV Testing Services in Rural Southwestern Uganda
(AIDS and Behavior, 2020)In southwestern Uganda, where HIV prevalence among sexually active adults is ~ 7% [1], we have been conducting longitudinal research to improve uptake of HIV testing among communities who utilize informal health providers, ... -
Conceptual model for pluralistic healthcare behaviour: results from a qualitative study in southwestern Uganda
(BMJ open, 2020)Introduction: Medical pluralism, or concurrent utilisation of multiple therapeutic modalities, is common in various international contexts, and has been characterised as a factor contributing to poor health outcomes in ... -
Burden of heart diseases in children attending cardiology clinic in a regional referral hospital in Uganda
(International Clinical Pathology Journal, 2017)Introduction: Patterns and prevalence of heart diseases are different between the high income countries and low income countries. Acquired heart diseases like RHD, cardiomyopathies, pericarditis are still a public health ... -
Newborn care knowledge and practices among care givers of newborns and young infants attending a regional referral hospital in Southwestern Uganda
(PloS one, 2024-05-07)A child born in developing countries has a 10 times higher mortality risk compared to one born in developed countries. Uganda still struggles with a high neonatal mortality rate at 27/ 1000 live births. Majority of these ... -
Antimicrobial treatment practices among Ugandan children with suspicion of central nervous system infection
(PLoS One, 2018)Acute central nervous system (CNS) infections in children in sub-Saharan Africa are often fatal. Potential contributors include late presentation, limited diagnostic capacity and inadequate treatment. A more nuanced ... -
Prediction models for post-discharge mortality among under-five children with suspected sepsis in Uganda: A multicohort analysis
(PLOS Global Public Health, 2024)In many low-income countries, over five percent of hospitalized children die following hospital discharge. The lack of available tools to identify those at risk of post-discharge mortality has limited the ability to make ... -
From ‘intuitive’ pragmatic interventions to a systematic approach e Using implementation science to improve childhood cancer survival in low-income settings: The CANCaRe Africa experience
(Pediatric Hematology Oncology Journal, 2024)Implementation science is a relatively young field of study and is the science of delivering evidence based interventions into routine health care. RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) ... -
The level of antiretroviral therapy (ART) adherence among orphan children and adolescents living with HIV/AIDS: A systematic review and meta-analysis
(Plos one, 2024)Background: Many children and adolescents living with HIV have ended up as orphans. Due to HIV taking away their parents leaves them deprived of their most important social network and support, which predisposes them to ... -
Cost-effectiveness of community-based household tuberculosis contact management for children in Cameroon and Uganda: a modelling analysis of a cluster-randomised trial
(he Lancet Global Health, 2023)Background: WHO recommends household contact management (HCM) including contact screening and tuberculosis preventive treatment (TPT) for eligible children. The CONTACT trial found increased TPT initiation and completion ... -
Verbal Autopsy to Assess Postdischarge Mortality in Children With Suspected Sepsis in Uganda
(Pediatrics, 2023)Background: Reducing child mortality in low-income countries is constrained by a lack of vital statistics. In the absence of such data, verbal autopsies provide an acceptable method to determining attributable causes of ...
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