Browsing Research Article by Title
Now showing items 1-20 of 117
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The 2024 Pediatric Sepsis Challenge: Predicting In-Hospital Mortality in Children With Suspected Sepsis in Uganda
(Pediatric Critical Care Medicine, 2024)The aim of this “Technical Note” is to inform the pediatric critical care data research community about the “2024 Pediatric Sepsis Data Challenge.” This competition aims to facilitate the development of open-source algorithms ... -
Acceptability of a new 4-in-1 Abacavir/ Lamivudine/Lopinavir/Ritonavir paediatric fixed-dose combination: the caregiver–child dyads’ perspective
(Therapeutic Advances in Infectious Disease, 2023)Background: Worldwide, 1.7 million children younger than 15 years were living with HIV in 2021. Only 52% of them had access to antiretrovirals (ARVs). Lack of age-appropriate ARV formulations (i.e. easy to swallow for young ... -
Addressing the childhood cancer crisis in sub-Saharan Africa
(The Lancet Oncology, 2023)Sub-Saharan Africa is facing a childhood cancer crisis. Annually, nearly 90% of the more than 100 000 children who develop cancer in sub-Saharan Africa die. By contrast, 85% of paediatric patients with cancer survive in ... -
Adolescent Abstinence and Unprotected Sex in CyberSenga, an Internet-Based HIV Prevention Program: Randomized Clinical Trial of Efficacy
(PLoS ONE, 2013)Context: Cost-effective, scalable programs are urgently needed in countries deeply affected by HIV. Methods: This parallel-group RCT was conducted in four secondary schools in Mbarara, Uganda. Participants were 12 years ... -
Antimicrobial treatment practices among Ugandan children with suspicion of central nervous system infection
(PLoS One, 2018)Acute central nervous system (CNS) infections in children in sub-Saharan Africa are often fatal. Potential contributors include late presentation, limited diagnostic capacity and inadequate treatment. A more nuanced ... -
Application of sepsis definitions to pediatric patients admitted with suspected infections in Uganda
(A journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2017-05)Objectives: Acute infectious diseases are the most common cause of under-5 mortality. However, the hospital burden of non-neonatal pediatric sepsis has not previously been described in the resource poor setting. The objective ... -
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
(The Lancet, 2010)Background: Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from ... -
Assessment of HIV antiretroviral therapy adherence by measuring drug concentrations in hair among children in rural Uganda
(AIDS Care, 2015)Current tools for measuring medication adherence have significant limitations, especially among pediatric populations. We conducted a prospective observational study to assess the use of antiretroviral (ARV) drug levels ... -
The Bacterial and Viral Complexity of Post-infectious Hydrocephalus in Uganda
(Science translational medicine, 2020-05-06)Postinfectious hydrocephalus (PIH), often following neonatal sepsis, is the most common cause of pediatric hydrocephalus world-wide, yet the microbial pathogens remain uncharacterized. Characterization of the microbial ... -
Burden of heart diseases in children attending cardiology clinic in a regional referral hospital in Uganda
(International Clinical Pathology Journal, 2017)Introduction: Patterns and prevalence of heart diseases are different between the high income countries and low income countries. Acquired heart diseases like RHD, cardiomyopathies, pericarditis are still a public health ... -
A call to bridge the diagnostic gap: diagnostic solutions for neonatal sepsis in low- and middle- income countries
(BMJ global health, 2024)The first month of life is the most critical period for an infant’s survival, yet the most neglected for the provision of quality care. Each year, an estimated 2.3 million neonates die in their first month of life.1 Sepsis ... -
Caregiver Perceptions and Motivation for Disclosing or Concealing the Diagnosis of HIV Infection to Children Receiving HIV Care in Mbarara, Uganda: A Qualitative Study
(2014-03-25)Background: Disclosure of the diagnosis of HIV to HIV-infected children is challenging for caregivers. Despite current recommendations, data suggest that levels of disclosure of HIV status to HIV-infected children receiving ... -
Cell phone usage among adolescents in Uganda: acceptability for relaying health information
(HEALTH EDUCATION RESEARCH, 2011-03-15)The increase in cell phone use has manifested a growing interest in using this technology for health promotion. The portability and ‘always on’ features of the cell phone, along with increasing capability for the devices ... -
Challenges in using mobile phones for collection of antiretroviral therapy adherence data in a resource-limited setting
(AIDS and Behavior, 2010-12)Frequent antiretroviral therapy adherence monitoring could detect incomplete adherence before viral rebound develops and thus potentially prevent treatment failure. Mobile phone technologies make frequent, brief adherence ... -
Clinical profiles, incidence and predictors of early neonatal mortality at Mbarara Regional Referral Hospital, south-western Uganda
(BMC pediatrics, 2024)Background: The current neonatal mortality rate in Uganda is high at 22 deaths per 1000 live births, while it had been stagnant at 27 deaths per 1000 live births in the past decade. This is still more than double the World ... -
Community readiness and acceptance for the implementation of a novel malaria vaccine among at-risk children in sub-saharan Africa: a systematic review protocol
(Malaria Journal, 2024)Background: The World Health Organization novel malaria vaccine for at-risk children has the potential to greatly reduce the current malaria burden in sub-Saharan Africa. However, most studies have reported contradictory ... -
Conceptual model for pluralistic healthcare behaviour: results from a qualitative study in southwestern Uganda
(BMJ open, 2020)Introduction: Medical pluralism, or concurrent utilisation of multiple therapeutic modalities, is common in various international contexts, and has been characterised as a factor contributing to poor health outcomes in ... -
Cost effectiveness of a novel device for improving resuscitation of apneic newborns
(BMC Pediatrics, 2020)Background: Intrapartum-related hypoxic events are a major cause of morbidity and mortality in low resource countries. Neonates who receive proper resuscitation may go on to live otherwise healthy lives. However, even when ... -
Cost-effectiveness of community-based household tuberculosis contact management for children in Cameroon and Uganda: a modelling analysis of a cluster-randomised trial
(he Lancet Global Health, 2023)Background: WHO recommends household contact management (HCM) including contact screening and tuberculosis preventive treatment (TPT) for eligible children. The CONTACT trial found increased TPT initiation and completion ... -
Designing and evaluating a novel mobile application for Helping Babies Breathe skills retention in Uganda: comparative study protocol
(BMJ Paediatrics open, 2019-08)Introduction: Over 600 000 newborns die each year of intrapartum-related events, many of which are preventable in the presence of skilled birth attendants. Helping Babies Breathe (HBB) is a neonatal resuscitation training ...
